Gene Page: S100B

Summary
GeneID  6285
Symbol  S100B
Synonyms  NEF|S100|S100beta
Description  S100 calcium binding protein B
See related  HGNC:10500|MIM:176990|Ensembl:ENSG00000160307|HPRD:01505|
Locus tag  -
Gene type  protein-coding
Map location  21q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0192 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C9orf1420.790.72
ZNF5800.780.77
SCAND10.780.75
GAMT0.780.77
AC008532.10.780.77
C19orf200.780.78
C4orf480.770.73
YIF1B0.770.75
RABAC10.760.72
ZNHIT20.760.75
Top 10 negatively co-expressed genes
MT-CYB-0.35-0.35
AF347015.26-0.35-0.36
MT-ATP8-0.35-0.40
AF347015.8-0.35-0.34
AF347015.27-0.34-0.34
AF347015.15-0.33-0.33
AF347015.33-0.33-0.33
AF347015.2-0.33-0.33
AF347015.31-0.33-0.32
MT-CO2-0.32-0.31
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0048154S100 beta bindingIPIastrocyte (GO term level: 4)9519411 |10913138 
GO:0005509calcium ion bindingNAS9519411 
GO:0048306calcium-dependent protein bindingIDA10913138 
GO:0008270zinc ion bindingISS-
GO:0042803protein homodimerization activityIDA10913138 
GO:0042803protein homodimerization activityIPI9519411 
GO:0048156tau protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)8202493 
GO:0007409axonogenesisTASneuron, axon, neurite (GO term level: 12)8202493 
GO:0048168regulation of neuronal synaptic plasticityIEAneuron, Synap (GO term level: 9)-
GO:0008283cell proliferationTAS8202493 
GO:0007613memoryIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0001726ruffleIDA10913138 
GO:0005634nucleusIDA10913138 
GO:0005737cytoplasmIDA10913138 
GO:0005737cytoplasmISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGERMGC22357 | RAGEadvanced glycosylation end product-specific receptor-HPRD10399917 
AHNAKAHNAKRS | MGC5395AHNAK nucleoprotein-HPRD,BioGRID11312263 
ANXA6ANX6 | CBP68annexin A6-HPRD,BioGRID9883272 
CACYBPGIG5 | MGC87971 | PNAS-107 | RP1-102G20.6 | S100A6BP | SIPcalcyclin binding protein-HPRD12042313 
CAPZA1CAPPA1 | CAPZ | CAZ1capping protein (actin filament) muscle Z-line, alpha 1Reconstituted ComplexBioGRID12470955 
DESCMD1I | CSM1 | CSM2 | FLJ12025 | FLJ39719 | FLJ41013 | FLJ41793desmin-HPRD10510252 
ECDGCR2 | HSGT1ecdysoneless homolog (Drosophila)-HPRD12746458 
GFAPFLJ45472glial fibrillary acidic protein-HPRD10510252 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1-HPRD,BioGRID12377780 
MAPTDDPAC | FLJ31424 | FTDP-17 | MAPTL | MGC138549 | MSTD | MTBT1 | MTBT2 | PPND | TAUmicrotubule-associated protein tau-HPRD11264299 
-HPRD,BioGRID2833519 
NDRG1CAP43 | CMT4D | DRG1 | GC4 | HMSNL | NDR1 | NMSL | PROXY1 | RIT42 | RTP | TARG1 | TDD5N-myc downstream regulated 1-HPRD,BioGRID12493777 
PGM1-phosphoglucomutase 1Affinity Capture-Western
Far Western		BioGRID8894274 
S100A1S100 | S100-alpha | S100AS100 calcium binding protein A1Affinity Capture-Western
Two-hybrid		BioGRID9925766 |10913138 
|16189514 
S100A1 interacts with S100B.BIND10913138 
S100A11MLN70 | S100CS100 calcium binding protein A11-HPRD,BioGRID10913138 
S100A11 interacts with S100B.BIND10913138 
S100A62A9 | 5B10 | CABP | CACY | PRAS100 calcium binding protein A6-HPRD,BioGRID9925766 |10913138 
S100A6 interacts with S100B.BIND10913138 
S100BNEF | S100 | S100betaS100 calcium binding protein BAffinity Capture-Western
Two-hybrid		BioGRID9925766 |10913138 
S100B interacts with S100B.BIND10913138 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-WesternBioGRID15178678 
-HPRD10876243 |11527429 
VAV1VAVvav 1 guanine nucleotide exchange factorAffinity Capture-Western
Reconstituted Complex		BioGRID10394361 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 3830All SZGR genes in this pathway
REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 1815All SZGR genes in this pathway
REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 2317All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 2117All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING 1311All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 7357All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_DN 187115All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN 5438All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINED_IN_MONOCYTE_DN 87All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_UP 8351All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
ROSS_AML_WITH_PML_RARA_FUSION 7762All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_DN 184132All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
NIELSEN_SCHWANNOMA_UP 1816All SZGR genes in this pathway
LEIN_PONS_MARKERS 8959All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
ZHANG_TLX_TARGETS_UP 10878All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
CERIBELLI_GENES_INACTIVE_AND_BOUND_BY_NFY 4527All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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