Gene Page: S100B

Summary ?
GeneID6285
SymbolS100B
SynonymsNEF|S100|S100-B|S100beta
DescriptionS100 calcium binding protein B
ReferenceMIM:176990|HGNC:HGNC:10500|HPRD:01505|
Gene typeprotein-coding
Map location21q22.3
Pascal p-value0.033
Sherlock p-value0.471
eGeneMyers' cis & trans
SupportG2Cdb.human_clathrin
G2Cdb.human_Synaptosome
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0192 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1390969chr1233690104S100B62850.15trans
rs357840chr460005852S100B62850.12trans
rs3884624chr696112071S100B62850trans
rs17695935chr7140507936S100B62850.18trans
rs17070904chr1860917055S100B62850.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C9orf1420.790.72
ZNF5800.780.77
SCAND10.780.75
GAMT0.780.77
AC008532.10.780.77
C19orf200.780.78
C4orf480.770.73
YIF1B0.770.75
RABAC10.760.72
ZNHIT20.760.75
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CYB-0.35-0.35
AF347015.26-0.35-0.36
MT-ATP8-0.35-0.40
AF347015.8-0.35-0.34
AF347015.27-0.34-0.34
AF347015.15-0.33-0.33
AF347015.33-0.33-0.33
AF347015.2-0.33-0.33
AF347015.31-0.33-0.32
MT-CO2-0.32-0.31

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0048154S100 beta bindingIPIastrocyte (GO term level: 4)9519411 |10913138 
GO:0005509calcium ion bindingNAS9519411 
GO:0048306calcium-dependent protein bindingIDA10913138 
GO:0008270zinc ion bindingISS-
GO:0042803protein homodimerization activityIDA10913138 
GO:0042803protein homodimerization activityIPI9519411 
GO:0048156tau protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)8202493 
GO:0007409axonogenesisTASneuron, axon, neurite (GO term level: 12)8202493 
GO:0048168regulation of neuronal synaptic plasticityIEAneuron, Synap (GO term level: 9)-
GO:0008283cell proliferationTAS8202493 
GO:0007613memoryIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0001726ruffleIDA10913138 
GO:0005634nucleusIDA10913138 
GO:0005737cytoplasmIDA10913138 
GO:0005737cytoplasmISS-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGERMGC22357 | RAGEadvanced glycosylation end product-specific receptor-HPRD10399917 
AHNAKAHNAKRS | MGC5395AHNAK nucleoprotein-HPRD,BioGRID11312263 
ANXA6ANX6 | CBP68annexin A6-HPRD,BioGRID9883272 
CACYBPGIG5 | MGC87971 | PNAS-107 | RP1-102G20.6 | S100A6BP | SIPcalcyclin binding protein-HPRD12042313 
CAPZA1CAPPA1 | CAPZ | CAZ1capping protein (actin filament) muscle Z-line, alpha 1Reconstituted ComplexBioGRID12470955 
DESCMD1I | CSM1 | CSM2 | FLJ12025 | FLJ39719 | FLJ41013 | FLJ41793desmin-HPRD10510252 
ECDGCR2 | HSGT1ecdysoneless homolog (Drosophila)-HPRD12746458 
GFAPFLJ45472glial fibrillary acidic protein-HPRD10510252 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1-HPRD,BioGRID12377780 
MAPTDDPAC | FLJ31424 | FTDP-17 | MAPTL | MGC138549 | MSTD | MTBT1 | MTBT2 | PPND | TAUmicrotubule-associated protein tau-HPRD11264299 
MAPTDDPAC | FLJ31424 | FTDP-17 | MAPTL | MGC138549 | MSTD | MTBT1 | MTBT2 | PPND | TAUmicrotubule-associated protein tau-HPRD,BioGRID2833519 
NDRG1CAP43 | CMT4D | DRG1 | GC4 | HMSNL | NDR1 | NMSL | PROXY1 | RIT42 | RTP | TARG1 | TDD5N-myc downstream regulated 1-HPRD,BioGRID12493777 
PGM1-phosphoglucomutase 1Affinity Capture-Western
Far Western		BioGRID8894274 
S100A1S100 | S100-alpha | S100AS100 calcium binding protein A1Affinity Capture-Western
Two-hybrid		BioGRID9925766 |10913138 
|16189514 
S100A1S100 | S100-alpha | S100AS100 calcium binding protein A1S100A1 interacts with S100B.BIND10913138 
S100A11MLN70 | S100CS100 calcium binding protein A11-HPRD,BioGRID10913138 
S100A11MLN70 | S100CS100 calcium binding protein A11S100A11 interacts with S100B.BIND10913138 
S100A62A9 | 5B10 | CABP | CACY | PRAS100 calcium binding protein A6-HPRD,BioGRID9925766 |10913138 
S100A62A9 | 5B10 | CABP | CACY | PRAS100 calcium binding protein A6S100A6 interacts with S100B.BIND10913138 
S100BNEF | S100 | S100betaS100 calcium binding protein BAffinity Capture-Western
Two-hybrid		BioGRID9925766 |10913138 
S100BNEF | S100 | S100betaS100 calcium binding protein BS100B interacts with S100B.BIND10913138 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-WesternBioGRID15178678 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD10876243 |11527429 
VAV1VAVvav 1 guanine nucleotide exchange factorAffinity Capture-Western
Reconstituted Complex		BioGRID10394361 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRIF MEDIATED TLR3 SIGNALING 7454All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 9067All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR SIGNALING BY ERBB4 3830All SZGR 2.0 genes in this pathway
REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI 1815All SZGR 2.0 genes in this pathway
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX 2317All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED NFKB ACTIVATION 2117All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7757All SZGR 2.0 genes in this pathway
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING 1311All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 7253All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 7357All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 8363All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 9369All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 11884All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 14290All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 5438All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN MONOCYTE DN 87All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP 8351All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN 10884All SZGR 2.0 genes in this pathway
ROSS AML WITH PML RARA FUSION 7762All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184132All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
NIELSEN SCHWANNOMA UP 1816All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 8959All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221150All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP 10878All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
CERIBELLI GENES INACTIVE AND BOUND BY NFY 4527All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway