Gene Page: WRN

Summary ?
GeneID7486
SymbolWRN
SynonymsRECQ3|RECQL2|RECQL3
DescriptionWerner syndrome RecQ like helicase
ReferenceMIM:604611|HGNC:HGNC:12791|Ensembl:ENSG00000165392|HPRD:05212|Vega:OTTHUMG00000163894
Gene typeprotein-coding
Map location8p12
Pascal p-value0.022
Fetal beta0.947
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.03086 

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
WRNchr831004622CTNM_000553p.1146S>LmissenseSchizophreniaDNM:Fromer_2014

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg10709021830890108PURG;WRN1.583E-40.4320.032DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RAB6A0.930.91
ITFG10.920.92
ARMCX30.920.90
CLTC0.920.93
C5orf220.910.92
USP140.910.89
VPS410.910.88
PNMA20.910.89
SRPK20.910.91
NCKAP10.900.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.65-0.52
AF347015.2-0.65-0.53
MT-CO2-0.64-0.54
EIF4EBP3-0.63-0.65
AF347015.8-0.63-0.53
HIGD1B-0.63-0.54
FXYD1-0.62-0.55
AF347015.31-0.61-0.53
AF347015.26-0.61-0.49
MT-CYB-0.60-0.51

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000403Y-form DNA bindingIDA17715146 
GO:0000405bubble DNA bindingIDA11433031 
GO:0003677DNA bindingIDA9288107 
GO:0004003ATP-dependent DNA helicase activityIDA9288107 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:00084083'-5' exonuclease activityIDA10783163 |12181313 
GO:0009378four-way junction helicase activityIDA11433031 
GO:0016887ATPase activityIDA10373438 |10871376 
GO:0042803protein homodimerization activityIDA10783163 
GO:0032403protein complex bindingIDA10783163 
GO:00431383'-5' DNA helicase activityIDA17715146 
GO:0051880G-quadruplex DNA bindingIDA11433031 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000723telomere maintenanceIMP18212065 
GO:0000731DNA synthesis during DNA repairIDA17563354 
GO:0001302replicative cell agingIEA-
GO:0006310DNA recombinationIEA-
GO:0006284base-excision repairIDA17611195 
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processIEA-
GO:0010225response to UV-CIDA17563354 
GO:0010259multicellular organismal agingIMP16673358 
GO:0006979response to oxidative stressIDA17611195 
GO:0042981regulation of apoptosisIGI9681877 
GO:0051345positive regulation of hydrolase activityIDA17611195 
GO:0031297replication fork processingIDA17115688 
GO:0031297replication fork processingIMP12882351 
GO:0040009regulation of growth rateIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA17498979 
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005654nucleoplasmIDA11420665 |12944467 
GO:0005730nucleolusIDA9618508 |12181313 
GO:0032389MutLalpha complexIDA17715146 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedProtein-peptideBioGRID10608806 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndromeBLM interacts with WRN.BIND11919194 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndrome-HPRD,BioGRID11919194 
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)p14 interacts with WRN.BIND15355988 
FEN1FEN-1 | MF1 | RAD2flap structure-specific endonuclease 1-HPRD12356323 
FEN1FEN-1 | MF1 | RAD2flap structure-specific endonuclease 1Affinity Capture-Western
Reconstituted Complex		BioGRID11598021 |14688284 
MDC1DKFZp781A0122 | KIAA0170 | MGC166888 | NFBD1mediator of DNA damage checkpoint 1Protein-peptideBioGRID14578343 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1WRN interacts with PARP1.BIND14734561 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID10871373 |12633936 
POLR1CRPA39 | RPA40 | RPA5 | RPAC1polymerase (RNA) I polypeptide C, 30kDa-HPRD,BioGRID11971179 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptide-HPRD,BioGRID11889123 
RAD52-RAD52 homolog (S. cerevisiae)WRN interacts with RAD52.BIND12750383 
RDM1MGC33977 | RAD52BRAD52 motif 1-HPRD12750383 
TERF2TRBF2 | TRF2telomeric repeat binding factor 2-HPRD,BioGRID12181313 
TERF2TRBF2 | TRF2telomeric repeat binding factor 2Wrn interacts with TRF2.BIND12181313 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53WRN interacts with p53.BIND12080066 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11427532 |12080066 
WRNIP1FLJ22526 | RP11-420G6.2 | WHIP | bA420G6.2Werner helicase interacting protein 1-HPRD,BioGRID11301316 
XRCC5FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIVX-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)-HPRD,BioGRID12177300 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6WRN interacts with G22P1 (Ku70) as part of a complex.BIND14734561 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6-HPRD,BioGRID12177300 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID TELOMERASE PATHWAY 6848All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
MARKS ACETYLATED NON HISTONE PROTEINS 159All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 9 86All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM 15993All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 8157All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 8151All SZGR 2.0 genes in this pathway
COLLIS PRKDC SUBSTRATES 2015All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 6447All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN 7945All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway