Gene Page: PKP4

Summary
GeneID  8502
Symbol  PKP4
Synonyms  FLJ31261|FLJ42243|p0071
Description  plakophilin 4
See related  HGNC:9026|MIM:604276|Ensembl:ENSG00000144283|HPRD:05043|
Locus tag  -
Gene type  protein-coding
Map location  2q23-q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ANAPC20.930.93
BRF10.920.94
AC011498.30.920.93
SF40.920.92
CCDC1370.910.92
OGFR0.910.91
PPAN0.900.90
PELP10.900.91
ATAD3A0.900.92
ZNF6530.890.91
Top 10 negatively co-expressed genes
AF347015.31-0.80-0.82
MT-CO2-0.79-0.81
AF347015.33-0.77-0.78
MT-CYB-0.76-0.79
AF347015.27-0.76-0.80
AF347015.21-0.76-0.82
AF347015.8-0.75-0.80
AF347015.2-0.73-0.77
AF347015.15-0.73-0.78
HIGD1B-0.72-0.75
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-
GO:0005515protein bindingIEA-
GO:0005198structural molecule activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionNAS8937994 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005911cell-cell junctionTAS8937994 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Two-hybridBioGRID12615965 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Two-hybridBioGRID12615965 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD,BioGRID12426320 
p0071 interacts with VE-cadherin.BIND12426320 
DSC3CDHF3 | DSC | DSC1 | DSC2 | DSC4 | HT-CPdesmocollin 3-HPRD,BioGRID12615965 
DSPDPI | DPIIdesmoplakinp0071 interacts with desmoplakin.BIND12426320 
Two-hybridBioGRID12615965 
ERBB2IPERBIN | LAP2erbb2 interacting protein-HPRD,BioGRID11711544 
PDZD2AIPC | KIAA0300 | PAPIN | PDZK3 | PIN1PDZ domain containing 2PAPIN interacts with p0071. This interaction was modeled on a demonstrated interaction between rat PAPIN and human p0071.BIND10896674 
-HPRD,BioGRID12370826 
-HPRD10896674 
PSEN1AD3 | FAD | PS1 | S182presenilin 1-HPRD,BioGRID10037471 |10092585 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
DAWSON_METHYLATED_IN_LYMPHOMA_TCL1 5945All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
WEI_MIR34A_TARGETS 14897All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_UP 9864All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D5 3926All SZGR genes in this pathway
GAJATE_RESPONSE_TO_TRABECTEDIN_DN 1911All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5 7032All SZGR genes in this pathway
MILI_PSEUDOPODIA 4327All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_UP 7445All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9 7645All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-125/3511501561Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-1501701771A,m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-183481487m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-192/2152983051A,m8hsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-2186296361A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-233293361A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-3233283351A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-34/4496947011A,m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.