Gene Page: NMI

Summary ?
GeneID9111
SymbolNMI
Synonyms-
DescriptionN-myc and STAT interactor
ReferenceMIM:603525|HGNC:HGNC:7854|Ensembl:ENSG00000123609|HPRD:04632|Vega:OTTHUMG00000131867
Gene typeprotein-coding
Map location2q23
Pascal p-value0.214
Fetal beta-1.321

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.02395 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizotypy,schizophrenias,schizotypalClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003712transcription cofactor activityTAS10779520 
GO:0005515protein bindingIPI10597290 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006366transcription from RNA polymerase II promoterTAS9989503 
GO:0007259JAK-STAT cascadeTAS10597290 
GO:0006954inflammatory responseTAS9989503 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIDA10597290 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID11916966 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetBRCA1 interacts with Nmi.BIND11916966 
EMILIN1DKFZp586M121 | EMILIN | EMILIN-1 | gp115elastin microfibril interfacer 1Two-hybridBioGRID16189514 
GCSHGCE | NKHglycine cleavage system protein H (aminomethyl carrier)Two-hybridBioGRID16189514 
HDDC3MGC45386HD domain containing 3Two-hybridBioGRID16189514 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrateTwo-hybridBioGRID16189514 
HHLA3-HERV-H LTR-associating 3Affinity Capture-Western
Two-hybrid		BioGRID16189514 
IFI35FLJ21753 | IFP35interferon-induced protein 35-HPRD,BioGRID10950963 
IFI35FLJ21753 | IFP35interferon-induced protein 35Nmi and IFP 35 associate into a high molecular mass complex (HMMC).BIND10950963 
LSM4YER112WLSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)-HPRD,BioGRID15231747 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD8668343 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex		BioGRID11916966 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Myc interacts with NmiBIND11916966 
MYCNMODED | N-myc | NMYC | ODED | bHLHe37v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)-HPRD8668343 
NECAP2FLJ10420 | RP4-798A10.1NECAP endocytosis associated 2Two-hybridBioGRID16189514 
NMI-N-myc (and STAT) interactorNmi homodimerizes to form a complexBIND11916966 
PSMA1HC2 | MGC14542 | MGC14575 | MGC14751 | MGC1667 | MGC21459 | MGC22853 | MGC23915 | NU | PROS30proteasome (prosome, macropain) subunit, alpha type, 1Two-hybridBioGRID16189514 
SNAPC5SNAP19small nuclear RNA activating complex, polypeptide 5, 19kDaTwo-hybridBioGRID16189514 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID9989503 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDaNmi interacts with Stat1BIND9989503 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Nmi interacts with Stat3BIND9989503 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID9989503 
STAT4SLEB11signal transducer and activator of transcription 4Nmi interacts with Stat4. This interaction was modelled on a demonstrated interaction between Stat4 from an unspecified species and human Nmi.BIND9989503 
STAT5AMGF | STAT5signal transducer and activator of transcription 5ANmi interacts with Stat5aBIND9989503 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID9989503 
STAT5BSTAT5signal transducer and activator of transcription 5BNmi interacts with Stat5bBIND9989503 
STAT5BSTAT5signal transducer and activator of transcription 5B-HPRD,BioGRID9989503 
STAT6D12S1644 | IL-4-STAT | STAT6B | STAT6Csignal transducer and activator of transcription 6, interleukin-4 inducedNmi interacts with Stat6BIND9989503 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3cAffinity Capture-Western
Two-hybrid		BioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA IL2RB PATHWAY 3826All SZGR 2.0 genes in this pathway
BIOCARTA IL7 PATHWAY 1714All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 12778All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 11785All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR 6233All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193112All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 14780All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 10068All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 11476All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP 7448All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 5036All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 10267All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 14498All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP 7145All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 UP 1713All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 UP 4629All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP 3829All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271175All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 DN 228114All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240153All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243155All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway