Gene Page: RABEP1

Summary ?
GeneID9135
SymbolRABEP1
SynonymsRAB5EP|RABPT5
Descriptionrabaptin, RAB GTPase binding effector protein 1
ReferenceMIM:603616|HGNC:HGNC:17677|Ensembl:ENSG00000029725|HPRD:04684|Vega:OTTHUMG00000177870
Gene typeprotein-coding
Map location17p13.2
Pascal p-value0.022
Sherlock p-value0.815
eGeneCaudate basal ganglia
Cerebellum
Cortex
Myers' cis & trans
Meta
SupportINTRACELLULAR TRAFFICKING
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9912506chr175199037RABEP191350.19cis
rs3026109chr175284479RABEP191350.02cis
rs1065483chr175284769RABEP191350cis
rs1065483chr175284769RABEP191350.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NCAPG0.820.39
VRK10.780.45
C14orf230.750.35
ASF1A0.720.56
TIFA0.720.36
PDE1A0.710.37
RNF1380.710.44
DDX590.700.50
HCRTR20.700.34
SNX60.690.51
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC9A3R2-0.33-0.31
TENC1-0.32-0.45
LGI4-0.31-0.28
ZBTB47-0.31-0.29
BIN1-0.29-0.22
CCDC88B-0.29-0.33
AC018755.7-0.28-0.33
SUOX-0.28-0.06
PK4P-0.28-0.28
AC013356.5-0.28-0.21

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP1G1ADTG | CLAPG1 | MGC18255adaptor-related protein complex 1, gamma 1 subunitReconstituted Complex
Two-hybrid		BioGRID12042876 |12505986 
AP1G2G2ADadaptor-related protein complex 1, gamma 2 subunit-HPRD12505986 
EEA1MST105 | MSTP105 | ZFYVE2early endosome antigen 1Co-fractionationBioGRID10458612 
GAP43B-50 | PP46growth associated protein 43-HPRD,BioGRID9742146 
GGA1-golgi associated, gamma adaptin ear containing, ARF binding protein 1-HPRD,BioGRID12505986 
GGA2FLJ20966 | KIAA1080 | VEARgolgi associated, gamma adaptin ear containing, ARF binding protein 2-HPRD,BioGRID10747088 |11387476 
|12505986 
GGA3KIAA0154golgi associated, gamma adaptin ear containing, ARF binding protein 3-HPRD,BioGRID12505986 
HUNK-hormonally up-regulated Neu-associated kinase-HPRD,BioGRID11129044 
RAB1ADKFZp564B163 | RAB1 | YPT1RAB1A, member RAS oncogene familyReconstituted ComplexBioGRID11718716 
RAB33BDKFZp434G099 | MGC138182RAB33B, member RAS oncogene family-HPRD,BioGRID11718716 
RAB4AHRES-1/RAB4 | RAB4RAB4A, member RAS oncogene family-HPRD,BioGRID9524117 
RAB5ARAB5RAB5A, member RAS oncogene familyCo-purification
Reconstituted Complex
Two-hybrid		BioGRID8521472 |9045618 
|9524117 |11718716 
RAB5ARAB5RAB5A, member RAS oncogene family-HPRD8521472|9045618 
RABEP1RAB5EP | RABPT5rabaptin, RAB GTPase binding effector protein 1Co-fractionation
Reconstituted Complex
Two-hybrid		BioGRID9524117 
RABGEF1FLJ32302 | RABEX5 | rabex-5RAB guanine nucleotide exchange factor (GEF) 1-HPRD12505986 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2-HPRD9045618 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideAffinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK 8862All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE DN 8842All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172109All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 8460All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN 7247All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395249All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 13483All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN 14688All SZGR 2.0 genes in this pathway