Found 86 literature records

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Entrez ID	Description
274	Missplicing of a brain-specific exon of Bin1 in human melanoma is sufficient to abolish tumor suppressor properties; ectopic WT Bin1 activates PCD in malignant but not normal melanocytes.
7268	"TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin."
11009	"The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24."
5728	Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer.
7020	Results indicate that the tumor suppressor activity of AP2alpha is mediated through a direct interaction with p53.
7157	"azurin, tumor suppressor protein p53, and regression of cancer"
11009	study demonstrate that expression of the MDA-7 tumor suppressor can negatively regulate iNOS expression in malignant melanoma cell lines
1031	"Here we show that treatment of p18 null and heterozygous mice with a chemical carcinogen resulted in tumor development at an accelerated rate.Hence, p18 is a haploinsufficient tumor suppressor in mice."
4763	Status of the NF1 tumor suppressor locus in uveal melanoma.
4601	These findings support MXI1 as a putative tumor suppressor gene involved in conventional melanoma progression.
3621	Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nucleotide excision repair.
2131	Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.
9447	"Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2."
3622	The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells.
1029	The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity.
3622	The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation.
5927	that RBP2-H1 exerts a broad tumor-suppressive function partially mediated by pRb modulation
822	CapG is a new tumor suppressor gene involved in the tumorigenic progression of certain cancers
5728	Epigenetic PTEN silencing seems to be a relevant mechanism of inactivating this tumor suppressor gene in melanoma that may promote melanoma development by derepression of the AKT pathway.
1029	Physical and functional interaction of the p14ARF tumor suppressor with ribosomes.
10481	HOXB13 is downregulated by methylation and functions as a tumor suppressor in malignant melanoma.
6850	Syk tyrosine kinase is downregulated by methylation and functions as a tumor suppressor in malignant melanoma.
5468	"As keratinocyte-selective peroxisome proliferator-activated receptor gamma (PPARgamma) ablation had similar effects, RXRalpha/PPARgamma heterodimers most probably mediate epidermal tumor suppression."
139285	"findings show that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 and APC; data provide a possible mechanistic explanation for the tumor suppressor activity of WTX"
3621	Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells.
9447	The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.
11009	"MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity."
1029	the tumor suppressor activity of ARF in melanoma-genesis is p53 independent [news]
7490	The Wilms' tumor suppressor WT1 is associated with melanoma proliferation.
378708	"These results indicate that APITD1 is not the tumor suppressor gene on 1p36 responsible for the negative prognostic effect in uveal melanoma with concurrent loss of chromosome arm 1p, region 36, and chromosome 3."
5796	"PTPRK influences transactivating activity of beta-catenin in non-tumoral and neoplastic cells by regulating the balance between signaling and adhesive beta-catenin, thus providing biochemical basis for the hypothesis of PTPRK as a tumor suppressor gene."
11009	"Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24"
3621	Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
407040	miR-34a represents a tumor suppressor gene which is inactivated by CpG methylation and subsequent transcriptional silencing in a broad range of tumors.
7704	Increased expression of the tumor suppressor PLZF in malignant melanomas is associated with long-term patient survival.
5078	PAX4 has the potential to function as a tumor suppressor in human melanoma.
2619	"Gas1 has all the expected properties of a melanoma tumor suppressor: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and down-regulation in human melanoma metastasis."
10154	"Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression."
3487	conclusion: decreased IGFBP-4 tumor expression might be a step in the progression from primary to metastatic melanoma; data lend support to a recently-described novel tumor suppressor role of secreting IGFBPs in melanoma
6794	Role of LKB1 as a master regulator of polarity and metabolism could contribute to its tumor suppressor function.
1029	The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
5925	The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
639	Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
1029	Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.
1969	"Downregulation of EphA2 significantly inhibited invasion, proliferation and clonogenicity in vitro and suppressed tumorigenicity in vivo. Data provides the first in vivo evidence demonstrating a direct role for EphA2 in promoting melanoma tumorigenicity."
10154	"significant loss of Plexin C1 in metastatic melanoma compared with primary melanoma, suggesting the possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma"
864	Regulation of RUNX3 tumor suppressor gene expression in cutaneous melanoma.
7020	these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract
7020	these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract.
58189	"suggests that the tumor suppressive function of WFDC1 may be partially a result of up-regulated Dkk1 gene expression, which is known to be a potent inhibitor of the Wnt signaling pathway"

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