| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44000004 | HTLV-1 | ENSG00000168539.4 | protein_coding | CHRM1 | No | No | 1128 | P11229 Q53XZ3 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHRM1 |
|---|---|
| DrugBank ID | DB00777 |
| Drug Name | Propiomazine |
| Target ID | BE0004890 |
| UniProt ID | P08912 |
| Regulation Type | antagonist |
| PubMed IDs | 19110200; 19042969; 12678691; 14488364 |
| Citations | Kim DH, Maneen MJ, Stahl SM: Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia. Neurotherapeutics. 2009 Jan;6(1):78-85. doi: 10.1016/j.nurt.2008.10.020.@@Page CB, Duffull SB, Whyte IM, Isbister GK: Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal. QJM. 2009 Feb;102(2):123-31. doi: 10.1093/qjmed/hcn153. Epub 2008 Nov 28.@@Sharma A, Hamelin BA: Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. Curr Drug Metab. 2003 Apr;4(2):105-29. doi: 10.2174/1389200033489523.@@POWE CE, KIEM IM, FROMHAGEN C, CAVANAGH D: Propiomazine hydrochloride in obstetrical analgesia. A controlled study of 520 patients. JAMA. 1962 Jul 28;181:290-4. doi: 10.1001/jama.1962.03050300010002. |
| Groups | Approved |
| Direct Classification | Phenothiazines |
| SMILES | CCC(=O)C1=CC2=C(SC3=CC=CC=C3N2CC(C)N(C)C)C=C1 |
| Pathways | Propiomazine H1-Antihistamine Action |
| PharmGKB | PA164778685 |
| ChEMBL | CHEMBL1201210 |
