| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44000004 | HTLV-1 | ENSG00000168539.4 | protein_coding | CHRM1 | No | No | 1128 | P11229 Q53XZ3 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHRM1 |
|---|---|
| DrugBank ID | DB00804 |
| Drug Name | Dicyclomine |
| Target ID | BE0000092 |
| UniProt ID | P11229 |
| Regulation Type | antagonist |
| PubMed IDs | 17139284; 17016423; 19533734; 11752352; 3612532; 10661493; 11040260 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T, Kim HC: Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. J Neurosci Res. 2009 Dec;87(16):3658-70. doi: 10.1002/jnr.22159.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Doods HN, Mathy MJ, Davidesko D, van Charldorp KJ, de Jonge A, van Zwieten PA: Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors. J Pharmacol Exp Ther. 1987 Jul;242(1):257-62.@@Jiang ZW, Gong QZ, Di X, Zhu J, Lyeth BG: Dicyclomine, an M1 muscarinic antagonist, reduces infarct volume in a rat subdural hematoma model. Brain Res. 2000 Jan 3;852(1):37-44. doi: 10.1016/s0006-8993(99)02230-1.@@Fornari RV, Moreira KM, Oliveira MG: Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory. Learn Mem. 2000 Sep-Oct;7(5):287-92. doi: 10.1101/lm.34900. |
| Groups | Approved |
| Direct Classification | Carboxylic acid esters |
| SMILES | CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1 |
| Pathways | |
| PharmGKB | PA164744928 |
| ChEMBL | CHEMBL1123 |
