DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SPOP_SBC_1

Location: 3023:3027

E3 ligase: SPOP

DEGRON score: 0.9603

ASA_SCORE: 89.26

COIL: 0.9154

CONS_SCORE: 0.3244

DSS_SCORE: 0.6424

HELIX: 0.0158

FCONS_SCORE: 1.1872

RIG_SCORE: 0.6498

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3018S	SIDM00493	Other Solid Cancers	GDSC	APTTS	DEG_SPOP_SBC_1	0.1944
p.T3017S	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	0.1667

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Drug responses associated with MUC5AC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of APTTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	229:233	APTTS	SPOP	0.9695	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2323:2327	APTTS	SPOP	0.9841	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2319:2323	APTTS	SPOP	0.8129	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2327:2331	APTTS	SPOP	0.911	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2359:2363	APTTS	SPOP	0.9447	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2367:2371	APTTS	SPOP	0.9805	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2415:2419	APTTS	SPOP	0.8725	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2439:2443	APTTS	SPOP	0.7635	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2511:2515	APTTS	SPOP	0.9811	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2543:2547	APTTS	SPOP	0.79	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2583:2587	APTTS	SPOP	0.6039	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2607:2611	APTTS	SPOP	0.983	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2711:2715	APTTS	SPOP	0.8772	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2719:2723	APTTS	SPOP	0.9362	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2727:2731	APTTS	SPOP	0.8718	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2751:2755	APTTS	SPOP	0.9473	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2783:2787	APTTS	SPOP	0.6223	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2847:2851	APTTS	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2911:2915	APTTS	SPOP	0.9323	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2991:2995	APTTS	SPOP	0.6405	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3007:3011	APTTS	SPOP	0.8823	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3023:3027	APTTS	SPOP	0.9603	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3079:3083	APTTS	SPOP	0.9404	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3095:3099	APTTS	SPOP	0.963	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3103:3107	APTTS	SPOP	0.849	More...

Showing 1 to 25 of 59 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTS

Degron related mutations and impact score

Drug responses associated with MUC5AC mutations

All proteins holding degron of APTTS