DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 2323:2327

E3 ligase: SPOP

DEGRON score: 0.9841

ASA_SCORE: 87.92

COIL: 0.9106

CONS_SCORE: 0

DSS_SCORE: 0.4495

HELIX: 0.0148

FCONS_SCORE: 0

RIG_SCORE: 0.7244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2316I	TCGA-19-5956	GBM	TCGA	APTTS	DEG_SPOP_SBC_1	0.1389
p.R2316I	DO13863	GBM	ICGC	APTTS	DEG_SPOP_SBC_1	0.1389
p.P2324A	TCGA-AJ-A23N	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	0.6392
p.P2324A	DO43594	UCEC	ICGC	APTTS	DEG_SPOP_SBC_1	0.6392
p.L2331I	TCGA-B5-A1MR	UCEC	TCGA	APTTS	DEG_SPOP_SBC_1	0.2222
p.L2331I	DO41758	UCEC	ICGC	APTTS	DEG_SPOP_SBC_1	0.2222
p.G2314E	TCGA-EE-A29A	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	0.0833
p.G2314E	DO37416	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	0.0833
p.G2314R	TCGA-GN-A8LK	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	0.0833
p.G2314R	DO229502	SKCA	ICGC	APTTS	DEG_SPOP_SBC_1	0.0833
p.G2314R	DO51259	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	0.0833
p.A2322V	TCGA-IG-A50L	ESCA	TCGA	APTTS	DEG_SPOP_SBC_1	0.3056
p.P2324L	TCGA-Z2-A8RT	SKCM	TCGA	APTTS	DEG_SPOP_SBC_1	0.6471
p.P2324L	DO51301	SKCM	ICGC	APTTS	DEG_SPOP_SBC_1	0.6471
p.S2327F	DO220853	MELA	ICGC	APTTS	DEG_SPOP_SBC_1	0.7982
p.S2327F	DO220911	MELA	ICGC	APTTS	DEG_SPOP_SBC_1	0.7982
p.S2327F	DO222875	MELA	ICGC	APTTS	DEG_SPOP_SBC_1	0.7982
p.L2331F	SIDM01659	Kidney Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	0.2222
p.L2331F	ACH-000313	Kidney Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54725	UV excision repair protein RAD23 homolog A	DEG_SPOP_SBC_1	129:133	APTTS	SPOP	0.9978	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2319:2323	APTTS	SPOP	0.8129	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2327:2331	APTTS	SPOP	0.911	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2359:2363	APTTS	SPOP	0.9447	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2367:2371	APTTS	SPOP	0.9805	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2415:2419	APTTS	SPOP	0.8725	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2439:2443	APTTS	SPOP	0.7635	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2511:2515	APTTS	SPOP	0.9811	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2543:2547	APTTS	SPOP	0.79	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2583:2587	APTTS	SPOP	0.6039	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2607:2611	APTTS	SPOP	0.983	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2711:2715	APTTS	SPOP	0.8772	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2719:2723	APTTS	SPOP	0.9362	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2727:2731	APTTS	SPOP	0.8718	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2751:2755	APTTS	SPOP	0.9473	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2783:2787	APTTS	SPOP	0.6223	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2847:2851	APTTS	SPOP	0.9783	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2911:2915	APTTS	SPOP	0.9323	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2991:2995	APTTS	SPOP	0.6405	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3007:3011	APTTS	SPOP	0.8823	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3023:3027	APTTS	SPOP	0.9603	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3079:3083	APTTS	SPOP	0.9404	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3095:3099	APTTS	SPOP	0.963	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3103:3107	APTTS	SPOP	0.849	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3377:3381	APTTS	SPOP	0.7714	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3385:3389	APTTS	SPOP	0.9804	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3393:3397	APTTS	SPOP	0.9569	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3433:3437	APTTS	SPOP	0.9825	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3675:3679	APTTS	SPOP	0.7776	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3691:3695	APTTS	SPOP	0.5614	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3699:3703	APTTS	SPOP	0.9234	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3707:3711	APTTS	SPOP	0.5475	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3731:3735	APTTS	SPOP	0.961	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3739:3743	APTTS	SPOP	0.8637	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3747:3751	APTTS	SPOP	0.8451	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3794:3798	APTTS	SPOP	0.861	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3834:3838	APTTS	SPOP	0.7531	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3842:3846	APTTS	SPOP	0.5777	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3874:3878	APTTS	SPOP	0.9653	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4108:4112	APTTS	SPOP	0.9871	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4124:4128	APTTS	SPOP	0.639	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4156:4160	APTTS	SPOP	0.9926	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4172:4176	APTTS	SPOP	0.5021	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4188:4192	APTTS	SPOP	0.9727	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4244:4248	APTTS	SPOP	0.7883	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4308:4312	APTTS	SPOP	0.7096	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4356:4360	APTTS	SPOP	0.8749	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4524:4528	APTTS	SPOP	0.8005	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4556:4560	APTTS	SPOP	0.9486	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4580:4584	APTTS	SPOP	0.9551	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	229:233	APTTS	SPOP	0.9695	More...
Q70EL4	Ubiquitin carboxyl-terminal hydrolase 43	DEG_SPOP_SBC_1	799:803	APTTS	SPOP	0.9978	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2323:2327	APTTS	SPOP	0.9841	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	857:861	APTTS	SPOP	0.993	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1026:1030	APTTS	SPOP	0.9719	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	614:618	APTTS	SPOP	0.5103	More...
Q6UXN2	Trem-like transcript 4 protein	DEG_SPOP_SBC_1	132:136	APTTS	SPOP	0.846	More...
Q9BQW3	Transcription factor COE4	DEG_SPOP_SBC_1	533:537	APTTS	SPOP	0.605	More...
Q8NEQ5	Transmembrane protein C1orf162	DEG_SPOP_SBC_1	22:26	APTTS	SPOP	0.8112	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of APTTS