SZGR2

Summary ?

GeneID	11030
Symbol	RBPMS
Synonyms	HERMES
Description	RNA binding protein with multiple splicing
Reference	MIM:601558\|HGNC:HGNC:19097\|Ensembl:ENSG00000157110\|HPRD:11870\|Vega:OTTHUMG00000163845
Gene type	protein-coding
Map location	8p12
Pascal p-value	0.66
DMG	1 (# studies)
eGene	Cerebellum Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
CV:PheWAS	Phenome-wide association studies (PheWAS)	157 SNPs associated with schizophrenia	1
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.00057
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.03086
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.039

Section I. Genetics and epigenetics annotation

CV:PheWAS

SNP ID	Chromosome	Position	Allele	P	Function	Gene	Up/Down Distance
rs2979481	8	0	null	1.493	RBPMS	null

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg27258878	8	30407398	RBPMS	1.69E-5	0.255	0.015	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs10994209	chr10	61877705	RBPMS	11030		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RBM19	0.90	0.90
C17orf69	0.89	0.89
SRCAP	0.89	0.88
TNRC6A	0.89	0.90
SETD1A	0.89	0.88
BAT2	0.89	0.88
GIGYF1	0.88	0.91
TCOF1	0.88	0.89
RBM28	0.88	0.87
PCNT	0.88	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.66	-0.70
AF347015.21	-0.64	-0.77
B2M	-0.64	-0.66
AF347015.27	-0.64	-0.68
IFI27	-0.63	-0.66
C1orf54	-0.63	-0.76
SRGN	-0.62	-0.68
MT-CO2	-0.62	-0.67
VAMP5	-0.62	-0.71
HIGD1B	-0.62	-0.69

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003723	RNA binding	TAS		8855282
GO:0005515	protein binding	IPI		16189514 \|16713569
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006396	RNA processing	TAS		8855282

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGAP9	10C \| FLJ16525 \| MGC1295 \| RGL1	Rho GTPase activating protein 9	Two-hybrid	BioGRID	16189514
C12orf12	MGC26598	chromosome 12 open reading frame 12	Two-hybrid	BioGRID	16189514
C16orf48	DAKV6410 \| DKFZp434A1319	chromosome 16 open reading frame 48	Two-hybrid	BioGRID	16189514
C1orf94	MGC15882	chromosome 1 open reading frame 94	Two-hybrid	BioGRID	16189514
C2orf51	FLJ25369 \| TSC21	chromosome 2 open reading frame 51	Two-hybrid	BioGRID	16189514
C9orf100	FLJ14642 \| MGC44886 \| RP11-331F9.7	chromosome 9 open reading frame 100	Two-hybrid	BioGRID	16189514
C9orf86	FLJ10101 \| FLJ13045 \| Parf \| RBEL1 \| bA216L13.9 \| pp8875	chromosome 9 open reading frame 86	Two-hybrid	BioGRID	16189514
CCNK	CPR4 \| MGC9113	cyclin K	Two-hybrid	BioGRID	16189514
CDC23	APC8	cell division cycle 23 homolog (S. cerevisiae)	Two-hybrid	BioGRID	16189514
CDC42EP1	BORG5 \| CEP1 \| MGC15316 \| MSE55	CDC42 effector protein (Rho GTPase binding) 1	Two-hybrid	BioGRID	16189514
CNNM3	ACDP3 \| DKFZp434I1016 \| FLJ20018	cyclin M3	Two-hybrid	BioGRID	16189514
DAZAP2	KIAA0058 \| MGC14319 \| MGC766 \| PRTB	DAZ associated protein 2	Two-hybrid	BioGRID	16189514
DTX2	KIAA1528 \| MGC71098 \| RNF58	deltex homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
DVL2	-	dishevelled, dsh homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
EWSR1	EWS	Ewing sarcoma breakpoint region 1	Two-hybrid	BioGRID	16189514
EYA2	EAB1 \| MGC10614	eyes absent homolog 2 (Drosophila)	Two-hybrid	BioGRID	16189514
FAM103A1	C15orf18 \| HsT19360 \| MGC102778 \| MGC2560	family with sequence similarity 103, member A1	Two-hybrid	BioGRID	16189514
FASTK	FAST	Fas-activated serine/threonine kinase	Two-hybrid	BioGRID	16189514
FOXS1	FKHL18 \| FREAC10 \| MGC4544	forkhead box S1	Two-hybrid	BioGRID	16189514
FXR2	FMR1L2	fragile X mental retardation, autosomal homolog 2	Two-hybrid	BioGRID	16189514
GRAP2	GADS \| GRAP-2 \| GRB2L \| GRBLG \| GRID \| GRPL \| GrbX \| Grf40 \| Mona \| P38	GRB2-related adaptor protein 2	Two-hybrid	BioGRID	16189514
HEYL	HRT3 \| MGC12623 \| bHLHb33	hairy/enhancer-of-split related with YRPW motif-like	Two-hybrid	BioGRID	16189514
HOXA9	ABD-B \| HOX1 \| HOX1.7 \| HOX1G \| MGC1934	homeobox A9	Two-hybrid	BioGRID	16189514
HOXB9	HOX-2.5 \| HOX2 \| HOX2E	homeobox B9	Two-hybrid	BioGRID	16189514
KIAA0182	GSE1	KIAA0182	Two-hybrid	BioGRID	16189514
LRRC41	MGC126571 \| MGC126573 \| MUF1 \| PP7759 \| RP4-636H5.2	leucine rich repeat containing 41	Two-hybrid	BioGRID	16189514
LZTS2	KIAA1813 \| LAPSER1	leucine zipper, putative tumor suppressor 2	Two-hybrid	BioGRID	16189514
NEU4	MGC102757 \| MGC18222	sialidase 4	Two-hybrid	BioGRID	16189514
OTX1	FLJ38361 \| MGC15736	orthodenticle homeobox 1	Two-hybrid	BioGRID	16189514
PDLIM4	RIL	PDZ and LIM domain 4	Two-hybrid	BioGRID	16189514
PHF1	MTF2L2 \| PCL1 \| PHF2	PHD finger protein 1	Two-hybrid	BioGRID	16189514
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Two-hybrid	BioGRID	16189514
PITX1	BFT \| POTX \| PTX1	paired-like homeodomain 1	Two-hybrid	BioGRID	16189514
POM121	DKFZp586G1822 \| DKFZp586P2220 \| FLJ41820 \| KIAA0618 \| MGC3792 \| POM121A	POM121 membrane glycoprotein (rat)	Two-hybrid	BioGRID	16189514
RBM9	FOX2 \| Fox-2 \| HNRBP2 \| HRNBP2 \| RTA \| dJ106I20.3 \| fxh	RNA binding motif protein 9	Two-hybrid	BioGRID	16189514
RBPMS	HERMES	RNA binding protein with multiple splicing	Two-hybrid	BioGRID	16189514
RHOXF2	PEPP-2 \| PEPP2 \| THG1	Rhox homeobox family, member 2	Two-hybrid	BioGRID	16189514
SERF2	4F5REL \| FAM2C \| FLJ20431 \| FLJ37527 \| FLJ38557 \| H4F5rel \| HsT17089 \| MGC48826	small EDRK-rich factor 2	Two-hybrid	BioGRID	16189514
SF1	D11S636 \| ZFM1 \| ZNF162	splicing factor 1	Two-hybrid	BioGRID	16189514
SMUG1	FDG \| HMUDG \| MGC104370 \| UNG3	single-strand-selective monofunctional uracil-DNA glycosylase 1	Affinity Capture-Western Two-hybrid	BioGRID	16189514
STRBP	DKFZp434N214 \| FLJ11307 \| FLJ14223 \| FLJ14984 \| ILF3L \| MGC21529 \| MGC3405 \| SPNR \| p74	spermatid perinuclear RNA binding protein	Two-hybrid	BioGRID	16189514
TOLLIP	FLJ33531 \| IL-1RAcPIP	toll interacting protein	Two-hybrid	BioGRID	16189514
TRIP13	16E1BP	thyroid hormone receptor interactor 13	Two-hybrid	BioGRID	16189514
ZC3H10	FLJ14451 \| ZC3HDC10	zinc finger CCCH-type containing 10	Two-hybrid	BioGRID	16189514
ZNF581	FLJ22550 \| HSPC189	zinc finger protein 581	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP	205	140	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN	198	110	All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN	123	78	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP	133	78	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP	182	110	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP	157	91	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP	194	122	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN	242	165	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN	281	186	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP	157	104	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP	44	30	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN	240	171	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP	316	190	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT DN	47	32	All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN	95	57	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP	66	47	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
CASTELLANO HRAS AND NRAS TARGETS DN	8	6	All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS DN	14	14	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 TTD DN	84	63	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
DACOSTA ERCC3 ALLELE XPCS VS TTD DN	36	27	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
SIMBULAN UV RESPONSE NORMAL DN	33	27	All SZGR 2.0 genes in this pathway
TOMLINS PROSTATE CANCER DN	40	33	All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS	114	71	All SZGR 2.0 genes in this pathway
WU CELL MIGRATION	184	114	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
HALMOS CEBPA TARGETS DN	46	26	All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP	131	87	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP	182	119	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN	246	180	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN	86	62	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS DN	57	42	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY UP	86	48	All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS DN	46	28	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN	178	121	All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS	71	47	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN	142	94	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6	189	112	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP	156	92	All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP	45	28	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP	295	149	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP	51	32	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN	238	145	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4	196	124	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 10	33	22	All SZGR 2.0 genes in this pathway
VALK AML WITH EVI1	25	15	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
NIELSEN GIST VS SYNOVIAL SARCOMA DN	20	17	All SZGR 2.0 genes in this pathway
NIELSEN GIST	98	66	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP	387	225	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B	517	302	All SZGR 2.0 genes in this pathway
GENTLES LEUKEMIC STEM CELL UP	29	15	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP	162	103	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-145	303	309	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-329	220	226	m8	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-377	222	228	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-485-5p	364	370	m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RBPMS