SZGR2

Summary ?

GeneID	1434
Symbol	CSE1L
Synonyms	CAS\|CSE1\|XPO2
Description	CSE1 chromosome segregation 1-like (yeast)
Reference	MIM:601342\|HGNC:HGNC:2431\|Ensembl:ENSG00000124207\|HPRD:03217\|Vega:OTTHUMG00000033046
Gene type	protein-coding
Map location	20q13
Pascal p-value	0.001
Sherlock p-value	0.594
Fetal beta	2.028
DMG	1 (# studies)
eGene	Meta
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.humanNRC CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0208

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg26206598	20	47445432	CSE1L	0.003	2.496		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
RBM15B	0.97	0.97
MARCKSL1	0.96	0.92
AC004471.2	0.96	0.93
DBN1	0.96	0.95
TSSK2	0.96	0.93
KDM2B	0.96	0.95
JUP	0.95	0.92
ZNF48	0.95	0.95
SEMA4C	0.95	0.93
ZBTB12	0.95	0.94

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C5orf53	-0.75	-0.77
AF347015.27	-0.75	-0.91
AF347015.31	-0.74	-0.90
HLA-F	-0.73	-0.75
MT-CO2	-0.73	-0.90
AF347015.33	-0.72	-0.87
S100B	-0.72	-0.83
AIFM3	-0.72	-0.73
ALDOC	-0.71	-0.70
MT-CYB	-0.71	-0.87

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		17719542
GO:0008262	importin-alpha export receptor activity	TAS		9323134
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000059	protein import into nucleus, docking	IEA		-
GO:0008283	cell proliferation	TAS		7479798
GO:0006915	apoptosis	TAS		7479798
GO:0006886	intracellular protein transport	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	TAS		9323134
GO:0005643	nuclear pore	IEA		-
GO:0005737	cytoplasm	TAS		9323134

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	-	HPRD,BioGRID	12061792
HNRNPL	FLJ35509 \| HNRPL \| P/OKcl.14 \| hnRNP-L	heterogeneous nuclear ribonucleoprotein L	Two-hybrid	BioGRID	16169070
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	-	HPRD	14743216
KPNA1	IPOA5 \| NPI-1 \| RCH2 \| SRP1	karyopherin alpha 1 (importin alpha 5)	Reconstituted Complex	BioGRID	10523667
KPNA2	IPOA1 \| QIP2 \| RCH1 \| SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	Reconstituted Complex	BioGRID	9323134 \|10523667
KPNA4	IPOA3 \| MGC12217 \| MGC26703 \| QIP1 \| SRP3	karyopherin alpha 4 (importin alpha 3)	Reconstituted Complex	BioGRID	10523667
KPNA6	FLJ11249 \| IPOA7 \| KPNA7 \| MGC17918	karyopherin alpha 6 (importin alpha 7)	-	HPRD	10523667
PPP5C	FLJ36922 \| PP5 \| PPP5	protein phosphatase 5, catalytic subunit	Two-hybrid	BioGRID	16169070
RAN	ARA24 \| Gsp1 \| TC4	RAN, member RAS oncogene family	-	HPRD	9323134
RPL22	EAP \| HBP15 \| HBP15/L22	ribosomal protein L22	Two-hybrid	BioGRID	16169070
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD	11927559
TMEM62	FLJ23375	transmembrane protein 62	Two-hybrid	BioGRID	16169070
TNFRSF1B	CD120b \| TBPII \| TNF-R-II \| TNF-R75 \| TNFBR \| TNFR1B \| TNFR2 \| TNFR80 \| p75 \| p75TNFR	tumor necrosis factor receptor superfamily, member 1B	-	HPRD	14743216
YWHAG	14-3-3GAMMA	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	-	HPRD	15324660

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ST INTEGRIN SIGNALING PATHWAY	82	62	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA UP	43	27	All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP	181	101	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN	87	49	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP	293	179	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER UP	27	18	All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP	67	37	All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP	117	85	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION DN	122	67	All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP	69	40	All SZGR 2.0 genes in this pathway
SEIDEN MET SIGNALING	19	16	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN	47	34	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION	147	80	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP	50	30	All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK	143	96	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN	76	57	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN	245	154	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN	87	57	All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 DN	15	12	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN	371	218	All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP	120	89	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 4	48	32	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP	93	65	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP	210	124	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA	51	35	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN	249	165	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11	103	68	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP	84	51	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS	239	156	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR	128	73	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	482	488	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CSE1L