Gene Page: DDX5

Summary
GeneID  1655
Symbol  DDX5
Synonyms  DKFZp686J01190|G17P1|HLR1|HUMP68|p68
Description  DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
See related  HGNC:2746|MIM:180630|Ensembl:ENSG00000108654|HPRD:01615|
Locus tag  -
Gene type  protein-coding
Map location  17q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0876 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003712transcription cofactor activityIEA-
GO:0003723RNA bindingIEA-
GO:0003724RNA helicase activityNAS1996094 
GO:0005515protein bindingIPI17220478 |17353931 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesIEA-
GO:0008026ATP-dependent helicase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006397mRNA processingIEA-
GO:0008380RNA splicingIEA-
GO:0016049cell growthNAS2451786 
GO:0045941positive regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusNAS2451786 
GO:0005681spliceosomeIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP8AKAP95 | DKFZp586B1222A kinase (PRKA) anchor protein 8-HPRD,BioGRID11279182 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)p68 interacts with the p21 promoter.BIND15660129 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID12527917 
DDX17DKFZp761H2016 | P72 | RH70DEAD (Asp-Glu-Ala-Asp) box polypeptide 17p72 interacts with p68.BIND12595555 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-WesternBioGRID12527917 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Affinity Capture-Western
Two-hybrid		BioGRID10409727 
ESR1 (ER-alpha) interacts with DDX5 (p68). This interaction was modeled on a demonstrated interaction between ESR1 from an unspecified species and DDX5 from an unspecified species.BIND12738788 
FBLFIB | FLRN | RNU3IP1fibrillarin-HPRD,BioGRID10837141 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-WesternBioGRID15298701 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD14743216 
STK24MST-3 | MST3 | MST3B | STE20 | STK3serine/threonine kinase 24 (STE20 homolog, yeast)Affinity Capture-MSBioGRID17353931 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p68 interacts with p53.BIND15660129 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SPLICEOSOME 12872All SZGR genes in this pathway
BIOCARTA_AKAP95_PATHWAY 129All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON 335181All SZGR genes in this pathway
ZUCCHI_METASTASIS_DN 4429All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 4130All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
STONER_ESOPHAGEAL_CARCINOGENESIS_UP 3925All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
LEE_AGING_MUSCLE_UP 4533All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
ONO_AML1_TARGETS_UP 2414All SZGR genes in this pathway
ONO_FOXP3_TARGETS_UP 2315All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_UP 143100All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
ABRAMSON_INTERACT_WITH_AIRE 4533All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206163169m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-141/200a211217m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-5p43491Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d129135m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-205257263m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-324-3p209215m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-3251952011Ahsa-miR-325CCUAGUAGGUGUCCAGUAAGUGU
miR-49615211Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-539155161m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-544941011A,m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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