Gene Page: DSP

Summary ?
GeneID1832
SymbolDSP
SynonymsDCWHKTA|DP
Descriptiondesmoplakin
ReferenceMIM:125647|HGNC:HGNC:3052|Ensembl:ENSG00000096696|HPRD:00513|Vega:OTTHUMG00000014212
Gene typeprotein-coding
Map location6p24
Pascal p-value0.788
Fetal beta0.343
DMG1 (# studies)
eGeneMeta
SupportG2Cdb.humanARC
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0159 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg2106833967542819DSP3.77E-10-0.0117.51E-7DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PEF10.800.81
STOML10.770.81
ABHD14A0.770.80
SH3GLB20.760.83
ABHD80.760.79
MTCH10.760.81
RPUSD30.760.79
C6orf1540.750.79
DNAJC300.750.78
SH3BP10.750.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NSBP1-0.52-0.59
EIF5B-0.51-0.56
AF347015.18-0.43-0.34
ANP32B-0.42-0.49
RAB13-0.41-0.49
AC010300.1-0.41-0.48
AC005921.3-0.39-0.55
GPR125-0.38-0.36
CWF19L2-0.38-0.43
ANP32C-0.37-0.39

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005200structural constituent of cytoskeletonTAS9887343 
GO:0030674protein binding, bridgingIDA10908733 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008544epidermis developmentTAS9887343 
GO:0018149peptide cross-linkingIDA10908733 
GO:0030216keratinocyte differentiationIDA10908733 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001533cornified envelopeIDA10908733 
GO:0005737cytoplasmIEA-
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARID3ABRIGHT | DRIL1 | DRIL3 | E2FBP1AT rich interactive domain 3A (BRIGHT-like)-HPRD9780002 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD15500642 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidase-HPRD15500642 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidase-HPRD15500642 
CASP6MCH2caspase 6, apoptosis-related cysteine peptidase-HPRD15500642 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidase-HPRD15500642 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD15500642 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD,BioGRID9739078 
CSTASTF1 | STFAcystatin A (stefin A)Reconstituted ComplexBioGRID8999895 
DESCMD1I | CSM1 | CSM2 | FLJ12025 | FLJ39719 | FLJ41013 | FLJ41793desmin-HPRD,BioGRID9261168 
DSC1CDHF1 | DG2/DG3desmocollin 1-HPRD,BioGRID9606214 
DSPDPI | DPIIdesmoplakin-HPRD,BioGRID12101406 
EVPLEVPKenvoplakin-HPRD8999895 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon-HPRD14743216 
IVL-involucrinReconstituted ComplexBioGRID8999895 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobin-HPRD,BioGRID9348293 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobinPlakoglobin interacts with desmoplakin.BIND12426320 
KRT1CK1 | EHK1 | K1 | KRT1Akeratin 1-HPRD,BioGRID9261168 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD14743216 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)-HPRD14743216 
NFKBIBIKBB | TRIP9nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta-HPRD14743216 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD,BioGRID10801826 
PKP1B6P | MGC138829plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)-HPRD,BioGRID10852826 
PKP2ARVD9plakophilin 2-HPRD,BioGRID11790773 
PKP3-plakophilin 3PKP3 interacts with DSP(DP)BIND12707304 
PKP3-plakophilin 3Two-hybridBioGRID12707304 
PKP4FLJ31261 | FLJ42243 | p0071plakophilin 4p0071 interacts with desmoplakin.BIND12426320 
PKP4FLJ31261 | FLJ42243 | p0071plakophilin 4Two-hybridBioGRID12615965 
RELBI-REL | IRELv-rel reticuloendotheliosis viral oncogene homolog B-HPRD14743216 
STK24MST-3 | MST3 | MST3B | STE20 | STK3serine/threonine kinase 24 (STE20 homolog, yeast)Affinity Capture-MSBioGRID17353931 
VIMFLJ36605vimentin-HPRD,BioGRID9261168 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 7659All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 4026All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS 126All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 5437All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241146All SZGR 2.0 genes in this pathway
ROY WOUND BLOOD VESSEL DN 2214All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN 11879All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214134All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP 214144All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 7954All SZGR 2.0 genes in this pathway
MIDORIKAWA AMPLIFIED IN LIVER CANCER 5538All SZGR 2.0 genes in this pathway
AIGNER ZEB1 TARGETS 3515All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 13187All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 9258All SZGR 2.0 genes in this pathway
PETROVA PROX1 TARGETS UP 2816All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN 6545All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 3731All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 3926All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN 2314All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 24HR 2013All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160101All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P2 7955All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 6 7548All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C6 55All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 14895All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315215All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS UP 169105All SZGR 2.0 genes in this pathway