Gene Page: DSP

Summary
GeneID  1832
Symbol  DSP
Synonyms  DPI|DPII
Description  desmoplakin
See related  HGNC:3052|MIM:125647|Ensembl:ENSG00000096696|HPRD:00513|
Locus tag  -
Gene type  protein-coding
Map location  6p24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0159 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PEF10.800.81
STOML10.770.81
ABHD14A0.770.80
SH3GLB20.760.83
ABHD80.760.79
MTCH10.760.81
RPUSD30.760.79
C6orf1540.750.79
DNAJC300.750.78
SH3BP10.750.80
Top 10 negatively co-expressed genes
NSBP1-0.52-0.59
EIF5B-0.51-0.56
AF347015.18-0.43-0.34
ANP32B-0.42-0.49
RAB13-0.41-0.49
AC010300.1-0.41-0.48
AC005921.3-0.39-0.55
GPR125-0.38-0.36
CWF19L2-0.38-0.43
ANP32C-0.37-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005200structural constituent of cytoskeletonTAS9887343 
GO:0030674protein binding, bridgingIDA10908733 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008544epidermis developmentTAS9887343 
GO:0018149peptide cross-linkingIDA10908733 
GO:0030216keratinocyte differentiationIDA10908733 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001533cornified envelopeIDA10908733 
GO:0005737cytoplasmIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARID3ABRIGHT | DRIL1 | DRIL3 | E2FBP1AT rich interactive domain 3A (BRIGHT-like)-HPRD9780002 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD15500642 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidase-HPRD15500642 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidase-HPRD15500642 
CASP6MCH2caspase 6, apoptosis-related cysteine peptidase-HPRD15500642 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidase-HPRD15500642 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD15500642 
CDH57B4 | CD144 | FLJ17376cadherin 5, type 2 (vascular endothelium)-HPRD,BioGRID9739078 
CSTASTF1 | STFAcystatin A (stefin A)Reconstituted ComplexBioGRID8999895 
DESCMD1I | CSM1 | CSM2 | FLJ12025 | FLJ39719 | FLJ41013 | FLJ41793desmin-HPRD,BioGRID9261168 
DSC1CDHF1 | DG2/DG3desmocollin 1-HPRD,BioGRID9606214 
DSPDPI | DPIIdesmoplakin-HPRD,BioGRID12101406 
EVPLEVPKenvoplakin-HPRD8999895 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon-HPRD14743216 
IVL-involucrinReconstituted ComplexBioGRID8999895 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobin-HPRD,BioGRID9348293 
Plakoglobin interacts with desmoplakin.BIND12426320 
KRT1CK1 | EHK1 | K1 | KRT1Akeratin 1-HPRD,BioGRID9261168 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD14743216 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)-HPRD14743216 
NFKBIBIKBB | TRIP9nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta-HPRD14743216 
PECAM1CD31 | PECAM-1platelet/endothelial cell adhesion molecule-HPRD,BioGRID10801826 
PKP1B6P | MGC138829plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)-HPRD,BioGRID10852826 
PKP2ARVD9plakophilin 2-HPRD,BioGRID11790773 
PKP3-plakophilin 3PKP3 interacts with DSP(DP)BIND12707304 
Two-hybridBioGRID12707304 
PKP4FLJ31261 | FLJ42243 | p0071plakophilin 4p0071 interacts with desmoplakin.BIND12426320 
Two-hybridBioGRID12615965 
RELBI-REL | IRELv-rel reticuloendotheliosis viral oncogene homolog B-HPRD14743216 
STK24MST-3 | MST3 | MST3B | STE20 | STK3serine/threonine kinase 24 (STE20 homolog, yeast)Affinity Capture-MSBioGRID17353931 
VIMFLJ36605vimentin-HPRD,BioGRID9261168 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 126All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
ROY_WOUND_BLOOD_VESSEL_DN 2214All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
BIDUS_METASTASIS_UP 214134All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP 214144All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_DN 7954All SZGR genes in this pathway
MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER 5538All SZGR genes in this pathway
AIGNER_ZEB1_TARGETS 3515All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
MOREAUX_B_LYMPHOCYTE_MATURATION_BY_TACI_UP 9258All SZGR genes in this pathway
PETROVA_PROX1_TARGETS_UP 2816All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
CHANG_IMMORTALIZED_BY_HPV31_DN 6545All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 3926All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_DN 2314All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_24HR 2013All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P2 7955All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 7548All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C6 55All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_UP 169105All SZGR genes in this pathway


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