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| GeneID |
2897
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| Symbol |
GRIK1
|
| Synonyms |
EAA3|EEA3|GLR5|GLUR5
|
| Description |
glutamate receptor, ionotropic, kainate 1 |
| See related |
HGNC:4579|MIM:138245|Ensembl:ENSG00000171189|HPRD:00693| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
21q22.11 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 9 | | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0018 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
|
| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| INPP5A | 0.81 | 0.80 | | |
| ACHE | 0.81 | 0.74 | | |
| B3GALTL | 0.78 | 0.59 | | |
| RGS8 | 0.77 | 0.74 | | |
| C1orf127 | 0.76 | 0.51 | | |
| CACNG5 | 0.75 | 0.58 | | |
| TTC39A | 0.74 | 0.63 | | |
| RSPO4 | 0.74 | 0.43 | | |
| PRKCH | 0.74 | 0.43 | | |
| PCBP3 | 0.74 | 0.65 | | |
Top 10 negatively co-expressed genes | | AF347015.21 | -0.27 | -0.35 | | |
| AF347015.2 | -0.26 | -0.29 | | |
| EMX2 | -0.25 | -0.38 | | |
| PLAC9 | -0.24 | -0.30 | | |
| AL139819.3 | -0.24 | -0.39 | | |
| RPL31 | -0.24 | -0.26 | | |
| GNG11 | -0.24 | -0.39 | | |
| AF347015.31 | -0.24 | -0.31 | | |
| RLBP1 | -0.23 | -0.27 | | |
| FAM159B | -0.23 | -0.50 | | |
|
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005234 | extracellular-glutamate-gated ion channel activity | IEA | glutamate (GO term level: 11) | - |
| GO:0015277 | kainate selective glutamate receptor activity | IDA | glutamate (GO term level: 8) | 9335499 |
| GO:0015277 | kainate selective glutamate receptor activity | IEA | glutamate (GO term level: 8) | - |
| GO:0004872 | receptor activity | IEA | | - |
| GO:0005261 | cation channel activity | IEA | | - |
| GO:0005216 | ion channel activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0007417 | central nervous system development | TAS | Brain (GO term level: 6) | 10580501 |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | TAS | neuron, glutamate, Synap, Neurotransmitter (GO term level: 9) | 9335499 |
| GO:0007268 | synaptic transmission | IEA | neuron, Synap, Neurotransmitter (GO term level: 6) | - |
| GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 10580501 |
| GO:0007215 | glutamate signaling pathway | TAS | glutamate (GO term level: 7) | 8260617 |
| GO:0006811 | ion transport | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005886 | plasma membrane | IEA | | - |
| GO:0005887 | integral to plasma membrane | TAS | | 8260617 |
| GO:0030054 | cell junction | IEA | | - |
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