SZGR2

Summary ?

GeneID	3586
Symbol	IL10
Synonyms	CSIF\|GVHDS\|IL-10\|IL10A\|TGIF
Description	interleukin 10
Reference	MIM:124092\|HGNC:HGNC:5962\|Ensembl:ENSG00000136634\|HPRD:00495\|Vega:OTTHUMG00000036386
Gene type	protein-coding
Map location	1q31-q32
Fetal beta	-0.241

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	3	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MRPL11	0.81	0.73
MPDU1	0.79	0.78
HADH	0.79	0.73
SNAPIN	0.78	0.75
C17orf81	0.78	0.78
STOML2	0.76	0.70
ADSL	0.76	0.70
VKORC1	0.75	0.78
MTX1	0.75	0.74
GABARAP	0.75	0.68

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.27	-0.46	-0.49
AF347015.18	-0.45	-0.54
AF347015.8	-0.45	-0.48
MT-ATP8	-0.45	-0.53
AF347015.26	-0.45	-0.50
MT-CYB	-0.44	-0.47
AF347015.15	-0.42	-0.47
MT-CO2	-0.42	-0.44
AF347015.33	-0.41	-0.45
AF347015.2	-0.41	-0.45

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005141	interleukin-10 receptor binding	NAS		1847510
GO:0005125	cytokine activity	IEA		-
GO:0005515	protein binding	IPI		11485736
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0032800	receptor biosynthetic process	IDA	Neurotransmitter (GO term level: 5)	10443688
GO:0030886	negative regulation of myeloid dendritic cell activation	IEA	dendrite (GO term level: 8)	-
GO:0002740	negative regulation of cytokine secretion during immune response	IDA		10443688
GO:0002237	response to molecule of bacterial origin	IDA		17449476
GO:0007267	cell-cell signaling	IC		1847510
GO:0007253	cytoplasmic sequestering of NF-kappaB	NAS		10975994
GO:0006955	immune response	IEA		-
GO:0006954	inflammatory response	NAS		9463379
GO:0006916	anti-apoptosis	NAS		8312229
GO:0010468	regulation of gene expression	IDA		9184696
GO:0042100	B cell proliferation	NAS		8228801
GO:0030595	leukocyte chemotaxis	TAS		9405662
GO:0042130	negative regulation of T cell proliferation	NAS		8499633
GO:0042742	defense response to bacterium	IEA		-
GO:0032695	negative regulation of interleukin-12 production	IEA		-
GO:0042092	T-helper 2 type immune response	TAS		11244051
GO:0032715	negative regulation of interleukin-6 production	IDA		10443688
GO:0030097	hemopoiesis	TAS		11244051
GO:0030183	B cell differentiation	NAS		8228801
GO:0045191	regulation of isotype switching	NAS		8228801
GO:0050715	positive regulation of cytokine secretion	IDA		10443688
GO:0045347	negative regulation of MHC class II biosynthetic process	TAS		11244051
GO:0045348	positive regulation of MHC class II biosynthetic process	IEA		-
GO:0045355	negative regulation of interferon-alpha biosynthetic process	NAS		9637497
GO:0051384	response to glucocorticoid stimulus	IDA		10443688
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	NAS		1847510
GO:0005615	extracellular space	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	267	161	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION	48	36	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
KEGG ASTHMA	30	25	All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE	53	49	All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS	140	100	All SZGR 2.0 genes in this pathway
KEGG ALLOGRAFT REJECTION	38	34	All SZGR 2.0 genes in this pathway
BIOCARTA ASBCELL PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA CYTOKINE PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA INFLAM PATHWAY	29	24	All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY	22	20	All SZGR 2.0 genes in this pathway
BIOCARTA IL10 PATHWAY	17	14	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY	65	43	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN	205	127	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP	43	33	All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP	86	54	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 1	13	11	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 1Q32 AMPLICON	13	5	All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA UP	51	29	All SZGR 2.0 genes in this pathway
SU PANCREAS	54	30	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7	90	52	All SZGR 2.0 genes in this pathway
GAVIN PDE3B TARGETS	22	15	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP	115	80	All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS	73	55	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
BUDHU LIVER CANCER METASTASIS UP	10	7	All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN	41	25	All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS UP	23	15	All SZGR 2.0 genes in this pathway
SEIKE LUNG CANCER POOR SURVIVAL	11	8	All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS AND CYCLIC RGD	21	15	All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY DN	14	11	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN	414	237	All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE	114	62	All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS	344	197	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	140	146	1A	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-27	178	184	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	178	184	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-361	135	141	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p	205	211	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	205	212	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: IL10