Gene Page: IL10

Summary
GeneID  3586
Symbol  IL10
Synonyms  CSIF|IL-10|IL10A|MGC126450|MGC126451|TGIF
Description  interleukin 10
See related  HGNC:5962|MIM:124092|Ensembl:ENSG00000136634|HPRD:00495|
Locus tag  -
Gene type  protein-coding
Map location  1q31-q32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MRPL110.810.73
MPDU10.790.78
HADH0.790.73
SNAPIN0.780.75
C17orf810.780.78
STOML20.760.70
ADSL0.760.70
VKORC10.750.78
MTX10.750.74
GABARAP0.750.68
Top 10 negatively co-expressed genes
AF347015.27-0.46-0.49
AF347015.18-0.45-0.54
AF347015.8-0.45-0.48
MT-ATP8-0.45-0.53
AF347015.26-0.45-0.50
MT-CYB-0.44-0.47
AF347015.15-0.42-0.47
MT-CO2-0.42-0.44
AF347015.33-0.41-0.45
AF347015.2-0.41-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005141interleukin-10 receptor bindingNAS1847510 
GO:0005125cytokine activityIEA-
GO:0005515protein bindingIPI11485736 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0032800receptor biosynthetic processIDANeurotransmitter (GO term level: 5)10443688 
GO:0030886negative regulation of myeloid dendritic cell activationIEAdendrite (GO term level: 8)-
GO:0002740negative regulation of cytokine secretion during immune responseIDA10443688 
GO:0002237response to molecule of bacterial originIDA17449476 
GO:0007267cell-cell signalingIC1847510 
GO:0007253cytoplasmic sequestering of NF-kappaBNAS10975994 
GO:0006955immune responseIEA-
GO:0006954inflammatory responseNAS9463379 
GO:0006916anti-apoptosisNAS8312229 
GO:0010468regulation of gene expressionIDA9184696 
GO:0042100B cell proliferationNAS8228801 
GO:0030595leukocyte chemotaxisTAS9405662 
GO:0042130negative regulation of T cell proliferationNAS8499633 
GO:0042742defense response to bacteriumIEA-
GO:0032695negative regulation of interleukin-12 productionIEA-
GO:0042092T-helper 2 type immune responseTAS11244051 
GO:0032715negative regulation of interleukin-6 productionIDA10443688 
GO:0030097hemopoiesisTAS11244051 
GO:0030183B cell differentiationNAS8228801 
GO:0045191regulation of isotype switchingNAS8228801 
GO:0050715positive regulation of cytokine secretionIDA10443688 
GO:0045347negative regulation of MHC class II biosynthetic processTAS11244051 
GO:0045348positive regulation of MHC class II biosynthetic processIEA-
GO:0045355negative regulation of interferon-alpha biosynthetic processNAS9637497 
GO:0051384response to glucocorticoid stimulusIDA10443688 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS1847510 
GO:0005615extracellular spaceIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
A2MCPAMD5 | DKFZp779B086 | FWP007 | S863-7alpha-2-macroglobulin-HPRD,BioGRID10714547 
IL10CSIF | IL-10 | IL10A | MGC126450 | MGC126451 | TGIFinterleukin 10-HPRD,BioGRID7759550 |8590020 
|11717514 
IL10RACDW210A | HIL-10R | IL-10R1 | IL10Rinterleukin 10 receptor, alphaCo-crystal Structure
Co-purification
Reconstituted Complex		BioGRID7759550 |8248239 
|10231374 |11485736 
|11717514 
-HPRD7759550 |8248239 
|8897595 |10231374 
|11485736 |11717514 
IL10RBCDW210B | CRF2-4 | CRFB4 | D21S58 | D21S66 | IL-10R2interleukin 10 receptor, beta-HPRD9312047 |11485736 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 4836All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_ASTHMA 3025All SZGR genes in this pathway
KEGG_AUTOIMMUNE_THYROID_DISEASE 5349All SZGR genes in this pathway
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 140100All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
BIOCARTA_ASBCELL_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_DC_PATHWAY 2220All SZGR genes in this pathway
BIOCARTA_IL10_PATHWAY 1714All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_IL4_2PATHWAY 6543All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
MANTOVANI_NFKB_TARGETS_UP 4333All SZGR genes in this pathway
MANTOVANI_VIRAL_GPCR_SIGNALING_UP 8654All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_1 1311All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_1Q32_AMPLICON 135All SZGR genes in this pathway
KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP 5129All SZGR genes in this pathway
SU_PANCREAS 5430All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P7 9052All SZGR genes in this pathway
GAVIN_PDE3B_TARGETS 2215All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_UP 107All SZGR genes in this pathway
ONO_AML1_TARGETS_DN 4125All SZGR genes in this pathway
ONO_FOXP3_TARGETS_UP 2315All SZGR genes in this pathway
SEIKE_LUNG_CANCER_POOR_SURVIVAL 118All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS_AND_CYCLIC_RGD 2115All SZGR genes in this pathway
WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_DN 1411All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
BOSCO_TH1_CYTOTOXIC_MODULE 11462All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/981401461Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-271781841Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-361135141m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-369-3p2052111Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3742052121A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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