Summary ?
GeneID3586
SymbolIL10
SynonymsCSIF|GVHDS|IL-10|IL10A|TGIF
Descriptioninterleukin 10
ReferenceMIM:124092|HGNC:HGNC:5962|Ensembl:ENSG00000136634|HPRD:00495|Vega:OTTHUMG00000036386
Gene typeprotein-coding
Map location1q31-q32
Fetal beta-0.241

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MRPL110.810.73
MPDU10.790.78
HADH0.790.73
SNAPIN0.780.75
C17orf810.780.78
STOML20.760.70
ADSL0.760.70
VKORC10.750.78
MTX10.750.74
GABARAP0.750.68
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.46-0.49
AF347015.18-0.45-0.54
AF347015.8-0.45-0.48
MT-ATP8-0.45-0.53
AF347015.26-0.45-0.50
MT-CYB-0.44-0.47
AF347015.15-0.42-0.47
MT-CO2-0.42-0.44
AF347015.33-0.41-0.45
AF347015.2-0.41-0.45

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005141interleukin-10 receptor bindingNAS1847510 
GO:0005125cytokine activityIEA-
GO:0005515protein bindingIPI11485736 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0032800receptor biosynthetic processIDANeurotransmitter (GO term level: 5)10443688 
GO:0030886negative regulation of myeloid dendritic cell activationIEAdendrite (GO term level: 8)-
GO:0002740negative regulation of cytokine secretion during immune responseIDA10443688 
GO:0002237response to molecule of bacterial originIDA17449476 
GO:0007267cell-cell signalingIC1847510 
GO:0007253cytoplasmic sequestering of NF-kappaBNAS10975994 
GO:0006955immune responseIEA-
GO:0006954inflammatory responseNAS9463379 
GO:0006916anti-apoptosisNAS8312229 
GO:0010468regulation of gene expressionIDA9184696 
GO:0042100B cell proliferationNAS8228801 
GO:0030595leukocyte chemotaxisTAS9405662 
GO:0042130negative regulation of T cell proliferationNAS8499633 
GO:0042742defense response to bacteriumIEA-
GO:0032695negative regulation of interleukin-12 productionIEA-
GO:0042092T-helper 2 type immune responseTAS11244051 
GO:0032715negative regulation of interleukin-6 productionIDA10443688 
GO:0030097hemopoiesisTAS11244051 
GO:0030183B cell differentiationNAS8228801 
GO:0045191regulation of isotype switchingNAS8228801 
GO:0050715positive regulation of cytokine secretionIDA10443688 
GO:0045347negative regulation of MHC class II biosynthetic processTAS11244051 
GO:0045348positive regulation of MHC class II biosynthetic processIEA-
GO:0045355negative regulation of interferon-alpha biosynthetic processNAS9637497 
GO:0051384response to glucocorticoid stimulusIDA10443688 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS1847510 
GO:0005615extracellular spaceIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION 4836All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
KEGG ASTHMA 3025All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE 5349All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140100All SZGR 2.0 genes in this pathway
KEGG ALLOGRAFT REJECTION 3834All SZGR 2.0 genes in this pathway
BIOCARTA ASBCELL PATHWAY 1211All SZGR 2.0 genes in this pathway
BIOCARTA CYTOKINE PATHWAY 2216All SZGR 2.0 genes in this pathway
BIOCARTA INFLAM PATHWAY 2924All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY 2220All SZGR 2.0 genes in this pathway
BIOCARTA IL10 PATHWAY 1714All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY 6543All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 7060All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485293All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP 4333All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP 8654All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 1 1311All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 1Q32 AMPLICON 135All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA UP 5129All SZGR 2.0 genes in this pathway
SU PANCREAS 5430All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7 9052All SZGR 2.0 genes in this pathway
GAVIN PDE3B TARGETS 2215All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 11580All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 7355All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
BUDHU LIVER CANCER METASTASIS UP 107All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN 4125All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS UP 2315All SZGR 2.0 genes in this pathway
SEIKE LUNG CANCER POOR SURVIVAL 118All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS AND CYCLIC RGD 2115All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY DN 1411All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/981401461Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-271781841Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-361135141m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-369-3p2052111Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3742052121A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG