Gene Page: ASCL1

Summary
GeneID  429
Symbol  ASCL1
Synonyms  ASH1|HASH1|MASH1|bHLHa46
Description  achaete-scute complex homolog 1 (Drosophila)
See related  HGNC:738|MIM:100790|Ensembl:ENSG00000139352|HPRD:00011|
Locus tag  -
Gene type  protein-coding
Map location  12q23.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NT5DC20.900.83
SIRT60.900.90
MIIP0.900.87
ACTL6B0.900.90
SHF0.900.86
DCAF150.900.86
FAM110A0.890.86
ZNF8210.890.90
AGBL50.890.89
DOK40.890.88
Top 10 negatively co-expressed genes
HLA-F-0.72-0.76
AF347015.27-0.71-0.85
AF347015.31-0.69-0.83
MT-CO2-0.69-0.84
AF347015.33-0.69-0.83
MT-CYB-0.68-0.84
AIFM3-0.67-0.68
S100B-0.67-0.75
C5orf53-0.67-0.65
AF347015.8-0.67-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityNAS8390674 
GO:0005515protein bindingIPI10903890 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060165regulation of timing of subpallium neuron differentiationIEAneuron (GO term level: 11)-
GO:0060163subpallium neuron fate commitmentIEAneuron (GO term level: 11)-
GO:0007405neuroblast proliferationIEAneuron (GO term level: 8)-
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0048666neuron developmentIEAneuron (GO term level: 9)-
GO:0010001glial cell differentiationIEAGlial (GO term level: 8)-
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007219Notch signaling pathwayIEA-
GO:0007400neuroblast fate determinationIEA-
GO:0007389pattern specification processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMP2BMP2Abone morphogenetic protein 2-HPRD9197246 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-WesternBioGRID11564735 
MEF2AADCAD1 | RSRFC4 | RSRFC9myocyte enhancer factor 2A-HPRD,BioGRID8662987 
TCF4E2-2 | ITF2 | MGC149723 | MGC149724 | PTHS | SEF2 | SEF2-1 | SEF2-1A | SEF2-1B | bHLHb19transcription factor 4-HPRD,BioGRID10903890 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
FRASOR_TAMOXIFEN_RESPONSE_UP 5136All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
LI_AMPLIFIED_IN_LUNG_CANCER 178108All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_UP 11866All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
SHEPARD_BMYB_TARGETS 7441All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_UP 203130All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_UP 7148All SZGR genes in this pathway
FUJII_YBX1_TARGETS_UP 4328All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP 9761All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-22102010261Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-369-3p6696751Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3746696761A,m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-375100710131Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-493-5p7717771Ahsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-496811817m8hsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.