Gene Page: PDE4D

Summary ?
GeneID5144
SymbolPDE4D
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1
Descriptionphosphodiesterase 4D
ReferenceMIM:600129|HGNC:HGNC:8783|Ensembl:ENSG00000113448|HPRD:02530|Vega:OTTHUMG00000162218
Gene typeprotein-coding
Map location5q12
Fetal beta1.598
SupportG2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs1823068558676049null1.551PDE4Dnull


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KRT50.780.78
TUBA10.780.84
CHN10.770.83
FAM131A0.760.75
ALDOA0.760.83
GOT10.760.77
C8orf460.760.81
RUNDC3A0.750.76
ATP6V1E10.750.71
MDH10.750.75
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA1949-0.54-0.56
TUBB2B-0.53-0.64
SH3BP2-0.53-0.67
PDE9A-0.53-0.65
SH2D2A-0.52-0.65
UPF3A-0.52-0.66
ZNF311-0.51-0.50
FADS2-0.51-0.56
CARHSP1-0.51-0.66
SH2B2-0.51-0.63

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinasePDE4D4 interacts with Abl. This interaction was modelled on a demonstrated interaction between human PDE4D4 and abl from an unspecified species.BIND10571082 
AKAP6ADAP100 | ADAP6 | AKAP100 | KIAA0311 | MGC165020 | PRKA6 | mAKAPA kinase (PRKA) anchor protein 6-HPRD,BioGRID11296225 
ARRB1ARB1 | ARR1arrestin, beta 1The amino-terminus of PDE4D5 interacts with Beta-Arrestin 1.BIND14500724 
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2PDE4D5 interacts with Beta-Arrestin 2.BIND14500724 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESPDE4D4 interacts with Fyn SH3 domain.BIND10571082 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID10329691 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1RACK1 interacts with PDE4D5.BIND10329691 |11516626 
|12193273 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2PDE4D4 interacts with Grb2. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Grb2 from an unspecified species.BIND10571082 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homologPDE4D4 interacts with Lyn SH3 domain.BIND10571082 
PDE4DDPDE3 | HSPDE4D | PDE4DN2 | STRK1phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)-HPRD,BioGRID12387865 
PDE4DIPCMYA2 | DKFZp781J054 | MGC75440 | MMGLphosphodiesterase 4D interacting protein-HPRD,BioGRID11134006 
PIK3CGPI3CG | PI3K | PI3Kgamma | PIK3phosphoinositide-3-kinase, catalytic, gamma polypeptidePDE4D4 interacts with PI3K. This interaction was modelled on a demonstrated interaction between human PDE4D4 and PI3K from an unspecified species.BIND10571082 
SPTAN1(ALPHA)II-SPECTRIN | FLJ44613 | NEASspectrin, alpha, non-erythrocytic 1 (alpha-fodrin)PDE4D4 interacts with Fodrin. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Fodrin from an unspecified species.BIND10571082 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)PDE4D4 interacts with Src SH3 domain.BIND10571082 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PURINE METABOLISM 15996All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS 2520All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 13686All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS DN 6849All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 12686All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA SIZE DN 148All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 11471All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 10267All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225139All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART DN 4232All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
MATZUK OVULATION 1410All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C DN 5939All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
LEE SP4 THYMOCYTE 1411All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT 227128All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP 6644All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR UP 5541All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297194All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway