Gene Page: PLAT

Summary
GeneID  5327
Symbol  PLAT
Synonyms  DKFZp686I03148|T-PA|TPA
Description  plasminogen activator, tissue
See related  HGNC:9051|MIM:173370|Ensembl:ENSG00000104368|HPRD:01419|
Locus tag  -
Gene type  protein-coding
Map location  8p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.352 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IFI44L0.930.86
PARP90.910.87
IFIT30.900.81
IFIT10.890.72
TAP10.870.74
IRF90.860.72
IFI350.850.73
IFITM30.840.67
PSMB80.830.73
SP1100.830.79
Top 10 negatively co-expressed genes
NEURL4-0.50-0.64
TCOF1-0.50-0.57
SPTAN1-0.50-0.61
NOVA2-0.49-0.64
MYO18A-0.49-0.52
PELP1-0.49-0.60
CLIP2-0.49-0.58
RRP1-0.49-0.56
KIAA0427-0.48-0.59
DHX37-0.48-0.60
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006464protein modification processTAS3087818 
GO:0006508proteolysisTAS3087818 
GO:0007596blood coagulationTAS3839198 
GO:0048008platelet-derived growth factor receptor signaling pathwayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIDA18029348 
GO:0005576extracellular regionEXP2503541 |2962641 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIEA-
GO:0005737cytoplasmIEA-
GO:0030141secretory granuleIEA-
GO:0045177apical part of cellIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANXA2ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36 | PAP-IVannexin A2-HPRD,BioGRID11978811 |12468550 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulin-HPRD,BioGRID9359841 
CKAP4CLIMP-63 | ERGIC-63 | MGC99554 | p63cytoskeleton-associated protein 4-HPRD12913003 
CLEC3BDKFZp686H17246 | TN | TNAC-type lectin domain family 3, member B-HPRD,BioGRID12694198 
F10FX | FXAcoagulation factor X-HPRD,BioGRID11371191 
F2PTcoagulation factor II (thrombin)Co-crystal StructureBioGRID10543954 
FGAFib2 | MGC119422 | MGC119423 | MGC119425fibrinogen alpha chain-HPRD,BioGRID3088041 |11170397 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD15448144 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1-HPRD,BioGRID1909331 |8366113 
KRT8CARD2 | CK8 | CYK8 | K2C8 | K8 | KOkeratin 8-HPRD,BioGRID9988531 
LAMA1LAMAlaminin, alpha 1-HPRD,BioGRID8360181 
LAMA3BM600 | E170 | LAMNA | LOCS | lama3alaminin, alpha 3-HPRD10956663 
LAMA5KIAA1907laminin, alpha 5Reconstituted ComplexBioGRID10956663 
LRP1A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)-HPRD,BioGRID1502153 |10632583 
LRP1BLRP-DIT | LRPDITlow density lipoprotein-related protein 1B (deleted in tumors)-HPRD11384978 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD15861134 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD15861134 
PLATDKFZp686I03148 | T-PA | TPAplasminogen activator, tissue-HPRD9268299 
PLAUATF | UPA | URK | UROKINASE | u-PAplasminogen activator, urokinase-HPRD,BioGRID7721771 
SERPINA5PAI3 | PCI | PLANH3 | PROCIserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5-HPRD,BioGRID2551064 
SERPINE1PAI | PAI-1 | PAI1 | PLANH1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1-HPRD,BioGRID2110366 |8607113 
SERPING1C1IN | C1INH | C1NH | HAE1 | HAE2serpin peptidase inhibitor, clade G (C1 inhibitor), member 1-HPRD7586269 
SERPINI1DKFZp781N13156 | PI12 | neuroserpinserpin peptidase inhibitor, clade I (neuroserpin), member 1-HPRD,BioGRID12354288 
SPARCONsecreted protein, acidic, cysteine-rich (osteonectin)-HPRD2745554 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
BIOCARTA_AMI_PATHWAY 2013All SZGR genes in this pathway
BIOCARTA_FIBRINOLYSIS_PATHWAY 128All SZGR genes in this pathway
BIOCARTA_PLATELETAPP_PATHWAY 1410All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_INTEGRIN2_PATHWAY 2918All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CORRE_MULTIPLE_MYELOMA_UP 7445All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_SUSTAINDED_IN_ERYTHROCYTE_UP 4430All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_DN 12073All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
KERLEY_RESPONSE_TO_CISPLATIN_UP 4430All SZGR genes in this pathway
MISSIAGLIA_REGULATED_BY_METHYLATION_UP 12678All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_UP 6445All SZGR genes in this pathway
KORKOLA_TERATOMA 3925All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN 5745All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8P12_P11_AMPLICON 5732All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_UP 5430All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_UP 6140All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_UP 6440All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_UP 5634All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_UP 6042All SZGR genes in this pathway
LEE_LIVER_CANCER_DENA_UP 6040All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_UP 6235All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
NAKAJIMA_MAST_CELL 4634All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_UP 175116All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C1 1915All SZGR genes in this pathway
GERHOLD_ADIPOGENESIS_DN 6444All SZGR genes in this pathway
VERRECCHIA_EARLY_RESPONSE_TO_TGFB1 5843All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
TRACEY_RESISTANCE_TO_IFNA2_DN 3223All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
HUANG_FOXA2_TARGETS_DN 3621All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
ZHENG_IL22_SIGNALING_UP 5636All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_DN 4328All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
TSAI_RESPONSE_TO_RADIATION_THERAPY 3220All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP 8961All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN 13483All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP 10968All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K4ME3_AND_H3K27ME3 3421All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
NIELSEN_GIST_VS_SYNOVIAL_SARCOMA_DN 2017All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_DN 207139All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
STEGER_ADIPOGENESIS_DN 2515All SZGR genes in this pathway
WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2 5739All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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