SZGR2

Summary ?

GeneID	5501
Symbol	PPP1CC
Synonyms	PP-1G\|PP1C\|PPP1G
Description	protein phosphatase 1 catalytic subunit gamma
Reference	MIM:176914\|HGNC:HGNC:9283\|Ensembl:ENSG00000186298\|HPRD:08911\|Vega:OTTHUMG00000169531
Gene type	protein-coding
Map location	12q24.1-q24.2
Pascal p-value	5.654E-4
Sherlock p-value	0.854
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP Chromatin Remodeling Genes Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
STMN2	0.95	0.97
STMN1	0.93	0.95
CDC42	0.91	0.94
PWP1	0.91	0.92
ARL8A	0.91	0.92
NT5C3	0.91	0.92
ARMCX1	0.90	0.94
ARMCX5	0.90	0.92
TTLL1	0.90	0.92
MLLT11	0.90	0.94

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.33	-0.81	-0.88
MT-CO2	-0.80	-0.87
AF347015.31	-0.80	-0.86
AF347015.27	-0.79	-0.86
HEPN1	-0.79	-0.83
HLA-F	-0.79	-0.82
MT-CYB	-0.78	-0.86
TSC22D4	-0.78	-0.85
AF347015.8	-0.77	-0.87
FXYD1	-0.77	-0.85

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005506	iron ion binding	IEA		-
GO:0005515	protein binding	IPI		17274640 \|17511879
GO:0004721	phosphoprotein phosphatase activity	IEA		-
GO:0016787	hydrolase activity	IEA		-
GO:0030145	manganese ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005977	glycogen metabolic process	IEA		-
GO:0005975	carbohydrate metabolic process	IEA		-
GO:0007049	cell cycle	IEA		-
GO:0051301	cell division	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP11	AKAP220 \| DKFZp781I12161 \| FLJ11304 \| KIAA0629 \| PRKA11	A kinase (PRKA) anchor protein 11	Affinity Capture-Western	BioGRID	12147701
MYO16	KIAA0865 \| MYR8 \| Myo16b	myosin XVI	-	HPRD	11588169
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	PPP1CC (TAPP) interacts with and dephosphorylates POLR2A (RNAPII). This interaction was modelled on a demonstrated interaction between human PPP1CC and POLR2A from an unspecified species.	BIND	12036313
PPP1R15A	GADD34	protein phosphatase 1, regulatory (inhibitor) subunit 15A	Affinity Capture-Western Phenotypic Suppression	BioGRID	11564868 \|12016208
PPP1R2	IPP2 \| MGC87148	protein phosphatase 1, regulatory (inhibitor) subunit 2	in vitro	BioGRID	10807923
PPP1R3D	DKFZp781L2441 \| PPP1R6	protein phosphatase 1, regulatory (inhibitor) subunit 3D	Reconstituted Complex	BioGRID	9414128
PPP1R8	ARD-1 \| ARD1 \| NIPP-1 \| NIPP1 \| PRO2047	protein phosphatase 1, regulatory (inhibitor) subunit 8	Reconstituted Complex	BioGRID	11104670
PPP1R9B	FLJ30345 \| PPP1R6 \| PPP1R9 \| SPINO \| Spn	protein phosphatase 1, regulatory (inhibitor) subunit 9B	Affinity Capture-Western Reconstituted Complex	BioGRID	10194355 \|10391935
RYR2	ARVC2 \| ARVD2 \| VTSIP	ryanodine receptor 2 (cardiac)	Co-fractionation	BioGRID	10830164
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Affinity Capture-Western Phenotypic Enhancement Reconstituted Complex	BioGRID	12016208
TLX1	HOX11 \| MGC163402 \| TCL3	T-cell leukemia homeobox 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9009195
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	-	HPRD	8549741
WBP11	DKFZp779M1063 \| NPWBP \| SIPP1	WW domain binding protein 11	-	HPRD	14640981

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
PID AURORA B PATHWAY	39	24	All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY	26	24	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	23	13	All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	26	16	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	13	11	All SZGR 2.0 genes in this pathway
REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	46	37	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE	87	51	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	63	42	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
CHOI ATL CHRONIC VS ACUTE DN	18	10	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE DN	51	35	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
COLLIS PRKDC REGULATORS	15	10	All SZGR 2.0 genes in this pathway
KIM GERMINAL CENTER T HELPER UP	66	42	All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER UP	57	35	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
KAMMINGA EZH2 TARGETS	41	26	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0	107	72	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
MATZUK SPERMATID DIFFERENTIATION	37	26	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP	207	143	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
MOOTHA GLYCOGEN METABOLISM	21	16	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP	104	67	All SZGR 2.0 genes in this pathway
WANG METASTASIS OF BREAST CANCER ESR1 UP	22	14	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN	414	237	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN	448	282	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	433	440	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	433	440	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-135	623	629	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	623	629	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-140	429	435	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-184	889	895	1A	hsa-miR-184	UGGACGGAGAACUGAUAAGGGU
miR-186	967	974	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-186	967	974	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-218	586	592	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-27	434	441	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	434	441	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-34/449	13	19	m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-34b	14	21	1A,m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-411	1110	1117	1A,m8	hsa-miR-411	AACACGGUCCACUAACCCUCAGU
miR-493-5p	501	508	1A,m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
				hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
				hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-496	335	342	1A,m8	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PPP1CC