Gene Page: PPP1CC

Summary
GeneID  5501
Symbol  PPP1CC
Synonyms  PPP1G
Description  protein phosphatase 1, catalytic subunit, gamma isoform
See related  HGNC:9283|MIM:176914|Ensembl:ENSG00000186298|HPRD:08911|
Locus tag  -
Gene type  protein-coding
Map location  12q24.1-q24.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
STMN20.950.97
STMN10.930.95
CDC420.910.94
PWP10.910.92
ARL8A0.910.92
NT5C30.910.92
ARMCX10.900.94
ARMCX50.900.92
TTLL10.900.92
MLLT110.900.94
Top 10 negatively co-expressed genes
AF347015.33-0.81-0.88
MT-CO2-0.80-0.87
AF347015.31-0.80-0.86
AF347015.27-0.79-0.86
HEPN1-0.79-0.83
HLA-F-0.79-0.82
MT-CYB-0.78-0.86
TSC22D4-0.78-0.85
AF347015.8-0.77-0.87
FXYD1-0.77-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0005515protein bindingIPI17274640 |17511879 
GO:0004721phosphoprotein phosphatase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0030145manganese ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0005977glycogen metabolic processIEA-
GO:0005975carbohydrate metabolic processIEA-
GO:0007049cell cycleIEA-
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP11AKAP220 | DKFZp781I12161 | FLJ11304 | KIAA0629 | PRKA11A kinase (PRKA) anchor protein 11Affinity Capture-WesternBioGRID12147701 
MYO16KIAA0865 | MYR8 | Myo16bmyosin XVI-HPRD11588169 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaPPP1CC (TAPP) interacts with and dephosphorylates POLR2A (RNAPII). This interaction was modelled on a demonstrated interaction between human PPP1CC and POLR2A from an unspecified species.BIND12036313 
PPP1R15AGADD34protein phosphatase 1, regulatory (inhibitor) subunit 15AAffinity Capture-Western
Phenotypic Suppression		BioGRID11564868 |12016208 
PPP1R2IPP2 | MGC87148protein phosphatase 1, regulatory (inhibitor) subunit 2in vitroBioGRID10807923 
PPP1R3DDKFZp781L2441 | PPP1R6protein phosphatase 1, regulatory (inhibitor) subunit 3DReconstituted ComplexBioGRID9414128 
PPP1R8ARD-1 | ARD1 | NIPP-1 | NIPP1 | PRO2047protein phosphatase 1, regulatory (inhibitor) subunit 8Reconstituted ComplexBioGRID11104670 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9BAffinity Capture-Western
Reconstituted Complex		BioGRID10194355 |10391935 
RYR2ARVC2 | ARVD2 | VTSIPryanodine receptor 2 (cardiac)Co-fractionationBioGRID10830164 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Affinity Capture-Western
Phenotypic Enhancement
Reconstituted Complex		BioGRID12016208 
TLX1HOX11 | MGC163402 | TCL3T-cell leukemia homeobox 1Affinity Capture-Western
Reconstituted Complex		BioGRID9009195 
TP53BP253BP2 | ASPP2 | BBP | PPP1R13A | p53BP2tumor protein p53 binding protein, 2-HPRD8549741 
WBP11DKFZp779M1063 | NPWBP | SIPP1WW domain binding protein 11-HPRD14640981 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
PID_AURORA_B_PATHWAY 3924All SZGR genes in this pathway
PID_INSULIN_GLUCOSE_PATHWAY 2624All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 2313All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 2616All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS 1311All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 4637All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHOI_ATL_CHRONIC_VS_ACUTE_DN 1810All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
APPIERTO_RESPONSE_TO_FENRETINIDE_DN 5135All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
COLLIS_PRKDC_REGULATORS 1510All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_UP 6642All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP 5735All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA 176122All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
KAMMINGA_EZH2_TARGETS 4126All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_DN 14199All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0 10772All SZGR genes in this pathway
LY_AGING_OLD_DN 5635All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
MATZUK_SPERMATID_DIFFERENTIATION 3726All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
MOOTHA_GLYCOGEN_METABOLISM 2116All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP 10467All SZGR genes in this pathway
WANG_METASTASIS_OF_BREAST_CANCER_ESR1_UP 2214All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1284334401A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-135623629m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-140429435m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-1848898951Ahsa-miR-184UGGACGGAGAACUGAUAAGGGU
miR-1869679741A,m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-218586592m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-274344411A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-34/4491319m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-34b14211A,m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-411111011171A,m8hsa-miR-411AACACGGUCCACUAACCCUCAGU
miR-493-5p5015081A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4963353421A,m8hsa-miR-496AUUACAUGGCCAAUCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.