SZGR2

Summary ?

GeneID	5515
Symbol	PPP2CA
Synonyms	PP2Ac\|PP2CA\|PP2Calpha\|RP-C
Description	protein phosphatase 2 catalytic subunit alpha
Reference	MIM:176915\|HGNC:HGNC:9299\|HPRD:08912\|
Gene type	protein-coding
Map location	5q31.1
Pascal p-value	0.42
Sherlock p-value	0.409
Fetal beta	-0.785
DMG	1 (# studies)
Support	G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
GSMA_I	Genome scan meta-analysis	Psr: 0.0032
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 6.9342

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg23307708	5	133561976	PPP2CA	1.99E-5	-0.452	0.016	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CHPT1	0.80	0.78
GYG1	0.77	0.71
SRI	0.76	0.69
TMEM22	0.76	0.66
NUDT6	0.75	0.67
GBAS	0.75	0.69
RAB9A	0.74	0.66
IL17RB	0.74	0.52
HMGCL	0.74	0.66
CYB5R1	0.73	0.64

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ZNF783	-0.43	-0.44
JAG2	-0.43	-0.43
AD000671.1	-0.43	-0.44
TNKS1BP1	-0.43	-0.44
UPF3A	-0.42	-0.47
BAHCC1	-0.42	-0.43
AC010536.2	-0.42	-0.43
HIC2	-0.42	-0.41
FBN3	-0.42	-0.41
SLC26A1	-0.42	-0.46

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005506	iron ion binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	IPI		9847399
GO:0004721	phosphoprotein phosphatase activity	IEA		-
GO:0016787	hydrolase activity	IEA		-
GO:0030145	manganese ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
GO:0046982	protein heterodimerization activity	IPI		9847399
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000188	inactivation of MAPK activity	NAS		11007961
GO:0008380	RNA splicing	NAS		11007961
GO:0006470	protein amino acid dephosphorylation	TAS		2849764 \|11007961
GO:0010033	response to organic substance	NAS		11007961
GO:0006275	regulation of DNA replication	NAS		11007961
GO:0006917	induction of apoptosis	TAS		11007961
GO:0006672	ceramide metabolic process	NAS		11007961
GO:0030111	regulation of Wnt receptor signaling pathway	NAS		11007961
GO:0007498	mesoderm development	IEA		-
GO:0030155	regulation of cell adhesion	NAS		11007961
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein	NAS		11007961
GO:0040008	regulation of growth	NAS		11360189
GO:0019932	second-messenger-mediated signaling	NAS		11007961
GO:0030308	negative regulation of cell growth	NAS		11007961
GO:0045595	regulation of cell differentiation	NAS		11360189
GO:0045449	regulation of transcription	NAS		11007961
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000159	protein phosphatase type 2A complex	TAS		11007961
GO:0005829	cytosol	IEA		-
GO:0005829	cytosol	TAS		11007961
GO:0005625	soluble fraction	NAS		11007961
GO:0005634	nucleus	NAS		11007961
GO:0005737	cytoplasm	IEA		-
GO:0005739	mitochondrion	NAS		11007961
GO:0005886	plasma membrane	IEA		-
GO:0015630	microtubule cytoskeleton	NAS		11007961

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARL2	ARFL2	ADP-ribosylation factor-like 2	Co-purification	BioGRID	12912990
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	9852076
BEST1	ARB \| BEST \| BMD \| TU15B \| VMD2	bestrophin 1	Affinity Capture-Western Reconstituted Complex	BioGRID	12058047
CCNG2	-	cyclin G2	Affinity Capture-Western Reconstituted Complex	BioGRID	11956189
CCT2	99D8.1 \| CCT-beta \| CCTB \| MGC142074 \| MGC142076 \| PRO1633 \| TCP-1-beta	chaperonin containing TCP1, subunit 2 (beta)	Affinity Capture-MS	BioGRID	18782753
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	Affinity Capture-MS	BioGRID	18782753
CCT4	CCT-DELTA \| Cctd \| MGC126164 \| MGC126165 \| SRB	chaperonin containing TCP1, subunit 4 (delta)	Affinity Capture-MS	BioGRID	18782753
CCT5	CCT-epsilon \| CCTE \| KIAA0098 \| TCP-1-epsilon	chaperonin containing TCP1, subunit 5 (epsilon)	Affinity Capture-MS	BioGRID	18782753
CCT6A	CCT-zeta \| CCT-zeta-1 \| CCT6 \| Cctz \| HTR3 \| MGC126214 \| MGC126215 \| MoDP-2 \| TCP-1-zeta \| TCP20 \| TCPZ \| TTCP20	chaperonin containing TCP1, subunit 6A (zeta 1)	Affinity Capture-MS	BioGRID	18782753
CCT7	CCT-ETA \| Ccth \| MGC110985 \| Nip7-1 \| TCP-1-eta	chaperonin containing TCP1, subunit 7 (eta)	Affinity Capture-MS	BioGRID	18782753
CCT8	C21orf112 \| Cctq \| D21S246 \| KIAA0002 \| PRED71	chaperonin containing TCP1, subunit 8 (theta)	Affinity Capture-MS	BioGRID	18782753
CDC5L	CEF1 \| KIAA0432 \| PCDC5RP \| dJ319D22.1 \| hCDC5	CDC5 cell division cycle 5-like (S. pombe)	in vitro in vivo Two-hybrid	BioGRID	10827081
CDK2	p33(CDK2)	cyclin-dependent kinase 2	Biochemical Activity Co-purification	BioGRID	10934208
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	Biochemical Activity Co-purification	BioGRID	10934208
CSNK1A1	CK1 \| HLCDGP1 \| PRO2975	casein kinase 1, alpha 1	Affinity Capture-MS	BioGRID	12062430
CTTNBP2	C7orf8 \| CORTBP2 \| FLJ34229 \| KIAA1758 \| MGC104579 \| Orf4	cortactin binding protein 2	Affinity Capture-MS	BioGRID	18782753
CTTNBP2NL	DKFZp547A023 \| FLJ13278	CTTNBP2 N-terminal like	Affinity Capture-MS	BioGRID	18782753
ETF1	D5S1995 \| ERF \| ERF1 \| MGC111066 \| RF1 \| SUP45L1 \| TB3-1	eukaryotic translation termination factor 1	Affinity Capture-Western Co-purification Two-hybrid	BioGRID	9003791
FAM40A	FLJ14743 \| KIAA1761 \| MGC148091 \| RP4-773N10.1	family with sequence similarity 40, member A	Affinity Capture-MS	BioGRID	18782753
FGFR1OP	FOP	FGFR1 oncogene partner	Affinity Capture-MS	BioGRID	18782753
IGBP1	ALPHA-4 \| IBP1	immunoglobulin (CD79A) binding protein 1	Affinity Capture-MS in vivo Two-hybrid	BioGRID	9647778 \|10441131 \|16085932 \|18782753
IGBP1	ALPHA-4 \| IBP1	immunoglobulin (CD79A) binding protein 1	-	HPRD	9647778 \|10441131 \|11371618
ISYNA1	INOS \| IPS \| Ino1	inositol-3-phosphate synthase 1	Two-hybrid	BioGRID	16169070
MOBKL3	2C4D \| CGI-95 \| MGC12264 \| MOB1 \| MOB3 \| PREI3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	Affinity Capture-MS	BioGRID	18782753
MRPS26	C20orf193 \| GI008 \| MRP-S13 \| MRP-S26 \| MRPS13 \| NY-BR-87 \| RPMS13 \| dJ534B8.3	mitochondrial ribosomal protein S26	Two-hybrid	BioGRID	16169070
PDCD10	CCM3 \| MGC1212 \| MGC24477 \| TFAR15	programmed cell death 10	Affinity Capture-MS	BioGRID	18782753
PPFIA1	FLJ41337 \| FLJ42630 \| FLJ43474 \| LIP.1 \| LIP1 \| LIPRIN \| MGC26800	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	Affinity Capture-MS	BioGRID	18782753
PPFIA2	FLJ41378 \| MGC132572	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	Affinity Capture-MS	BioGRID	18782753
PPFIA3	KIAA0654 \| LPNA3 \| MGC126567 \| MGC126569	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	Affinity Capture-MS	BioGRID	18782753
PPM1B	MGC21657 \| PP2C-beta-X \| PP2CB \| PP2CBETA \| PPC2BETAX	protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform	Co-purification	BioGRID	10934208
PPME1	FLJ22226 \| PME-1	protein phosphatase methylesterase 1	Affinity Capture-MS	BioGRID	18782753
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	12370081 \|18782753
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	A-alpha subunit interacts with C-alpha subunit of PP2A.	BIND	12370081
PPP2R1B	MGC26454 \| PR65B	protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform	Affinity Capture-MS Affinity Capture-Western Reconstituted Complex	BioGRID	12370081 \|18782753
PPP2R1B	MGC26454 \| PR65B	protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform	A-beta subunit interacts with C-alpha subunit of PP2A. This interaction was modeled on a demonstrated interaction between human A-beta subunit and rabbit C-alpha subunit.	BIND	11313937
PPP2R2A	B55-ALPHA \| B55A \| FLJ26613 \| MGC52248 \| PR52A \| PR55A	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	-	HPRD,BioGRID	1328247
PPP2R2C	B55-GAMMA \| IMYPNO \| IMYPNO1 \| MGC33570 \| PR52 \| PR55G	protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform	Affinity Capture-MS	BioGRID	18782753
PPP2R2D	MDS026	protein phosphatase 2, regulatory subunit B, delta isoform	Affinity Capture-MS	BioGRID	18782753
PPP2R3A	PPP2R3 \| PR130 \| PR72	protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha	Two-hybrid	BioGRID	10629059
PPP2R3B	NY-REN-8 \| PPP2R3L \| PPP2R3LY \| PR48	protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta	Affinity Capture-MS Two-hybrid	BioGRID	10629059 \|18782753
PPP2R5A	B56A \| MGC131915 \| PR61A	protein phosphatase 2, regulatory subunit B', alpha isoform	Affinity Capture-MS	BioGRID	18782753
PPP2R5B	B56B \| FLJ35411 \| PR61B	protein phosphatase 2, regulatory subunit B', beta isoform	Affinity Capture-MS	BioGRID	18782753
PPP2R5C	B56G \| MGC23064 \| PR61G	protein phosphatase 2, regulatory subunit B', gamma isoform	Affinity Capture-MS Affinity Capture-Western	BioGRID	10675325 \|18782753
PPP2R5D	B56D \| MGC2134 \| MGC8949	protein phosphatase 2, regulatory subunit B', delta isoform	Affinity Capture-MS	BioGRID	18782753
PPP2R5E	-	protein phosphatase 2, regulatory subunit B', epsilon isoform	Affinity Capture-MS in vivo	BioGRID	8703017 \|18782753
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	Biochemical Activity	BioGRID	11959144
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	Two-hybrid	BioGRID	16169070
PXN	FLJ16691	paxillin	Affinity Capture-Western	BioGRID	10675325
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Reconstituted Complex	BioGRID	11591705
RP5-1000E10.4	DKFZp686A0768 \| FLJ21168 \| SIKE	suppressor of IKK epsilon	Affinity Capture-MS	BioGRID	18782753
RP6-213H19.1	MASK \| MST4	serine/threonine protein kinase MST4	Affinity Capture-MS	BioGRID	18782753
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	-	HPRD	11438723
STK24	MST-3 \| MST3 \| MST3B \| STE20 \| STK3	serine/threonine kinase 24 (STE20 homolog, yeast)	Affinity Capture-MS	BioGRID	18782753
STK25	DKFZp686J1430 \| SOK1 \| YSK1	serine/threonine kinase 25 (STE20 homolog, yeast)	Affinity Capture-MS	BioGRID	18782753
STRN	MGC125642 \| SG2NA	striatin, calmodulin binding protein	Affinity Capture-MS	BioGRID	18782753
STRN	MGC125642 \| SG2NA	striatin, calmodulin binding protein	-	HPRD	10681496
STRN3	SG2NA	striatin, calmodulin binding protein 3	Affinity Capture-MS	BioGRID	18782753
STRN4	FLJ35594 \| ZIN \| zinedin	striatin, calmodulin binding protein 4	Affinity Capture-MS	BioGRID	18782753
TBCD	KIAA0988	tubulin folding cofactor D	Affinity Capture-Western	BioGRID	12912990
TCP1	CCT-alpha \| CCT1 \| CCTa \| D6S230E \| TCP-1-alpha	t-complex 1	Affinity Capture-MS	BioGRID	18782753
TLX1	HOX11 \| MGC163402 \| TCL3	T-cell leukemia homeobox 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9009195
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with PPP2CA. This interaction is modeled on a demonstrated interaction between p53 from an unspecified source and human PP2AC.	BIND	12556559
TRAF3IP3	DJ434O14.3 \| FLJ44151 \| MGC117354 \| MGC163289 \| T3JAM	TRAF3 interacting protein 3	Affinity Capture-MS	BioGRID	18782753
TRIP13	16E1BP	thyroid hormone receptor interactor 13	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
BIOCARTA AKAP95 PATHWAY	12	9	All SZGR 2.0 genes in this pathway
BIOCARTA AKT PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA CTCF PATHWAY	23	18	All SZGR 2.0 genes in this pathway
BIOCARTA P35ALZHEIMERS PATHWAY	11	9	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY	27	26	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
BIOCARTA MTOR PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA AKAPCENTROSOME PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY	42	35	All SZGR 2.0 genes in this pathway
BIOCARTA CK1 PATHWAY	17	17	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1MTOR PATHWAY	20	14	All SZGR 2.0 genes in this pathway
BIOCARTA TEL PATHWAY	18	15	All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY	26	24	All SZGR 2.0 genes in this pathway
WNT SIGNALING	89	71	All SZGR 2.0 genes in this pathway
PID ATR PATHWAY	39	25	All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY	46	25	All SZGR 2.0 genes in this pathway
PID MYC PATHWAY	25	22	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY	34	26	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY	55	38	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT	65	41	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME CTNNB1 PHOSPHORYLATION CASCADE	16	11	All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING	14	9	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	24	20	All SZGR 2.0 genes in this pathway
REACTOME ERKS ARE INACTIVATED	12	9	All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS	21	17	All SZGR 2.0 genes in this pathway
REACTOME GLYCOLYSIS	29	18	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING	78	56	All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS	25	20	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY	63	48	All SZGR 2.0 genes in this pathway
REACTOME CTLA4 INHIBITORY SIGNALING	21	15	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES	172	98	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS	78	49	All SZGR 2.0 genes in this pathway
REACTOME PLATELET SENSITIZATION BY LDL	16	9	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	13	6	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	35	17	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES	247	154	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE	87	51	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM	69	42	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	176	57	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN	92	51	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
COLLIS PRKDC REGULATORS	15	10	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES	147	87	All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP	145	91	All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING	94	56	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN	52	33	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1	72	45	All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX DN	54	43	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION	81	59	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2	118	65	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN	254	158	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1	148	95	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP	170	97	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP	140	81	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP	118	68	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
IKEDA MIR133 TARGETS UP	43	27	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B	517	302	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	476	482	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	476	482	1A	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-133	123	129	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	123	129	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-139	365	372	1A,m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-141/200a	645	651	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	645	651	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-17-5p/20/93.mr/106/519.d	180	186	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-183	135	142	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-188	478	484	1A	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-200bc/429	19	25	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-219	388	394	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-29	718	724	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-409-3p	97	104	1A,m8	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-452	384	390	1A	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-495	557	563	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PPP2CA