Gene Page: PPP3CC

Summary
GeneID  5533
Symbol  PPP3CC
Synonyms  CALNA3
Description  protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
See related  HGNC:9316|MIM:114107|Ensembl:ENSG00000120910|HPRD:00236|
Locus tag  -
Gene type  protein-coding
Map location  8p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KBTBD60.930.93
PANX10.920.95
REEP10.910.93
CTTNBP2NL0.910.95
KCTD100.910.93
PDIK1L0.910.95
HSDL10.910.94
HMGCR0.900.93
B4GALT50.900.95
DAAM10.900.92
Top 10 negatively co-expressed genes
AIFM3-0.68-0.76
AF347015.31-0.67-0.87
C5orf53-0.67-0.74
HLA-F-0.66-0.73
MT-CO2-0.66-0.87
HSD17B14-0.66-0.79
AF347015.27-0.66-0.84
TSC22D4-0.66-0.76
S100B-0.65-0.79
FXYD1-0.65-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0004721phosphoprotein phosphatase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008633activation of pro-apoptotic gene productsEXP15231831 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10195903 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CABIN1CAIN | KIAA0330 | PPP3INcalcineurin binding protein 1-HPRD11714752 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_HDAC_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_CALCINEURIN_PATHWAY 2117All SZGR genes in this pathway
BIOCARTA_NDKDYNAMIN_PATHWAY 2115All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY 3929All SZGR genes in this pathway
BIOCARTA_VIP_PATHWAY 2926All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY 2421All SZGR genes in this pathway
BIOCARTA_PGC1A_PATHWAY 2620All SZGR genes in this pathway
BIOCARTA_MEF2D_PATHWAY 2316All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY 4638All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
GAL_LEUKEMIC_STEM_CELL_DN 244153All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP 13680All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN 11671All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN 9558All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE 10568All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_UP 8648All SZGR genes in this pathway
KIM_GASTRIC_CANCER_CHEMOSENSITIVITY 10364All SZGR genes in this pathway
LEE_AGING_MUSCLE_DN 4629All SZGR genes in this pathway
ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN 5132All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP 196137All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-3828894m8hsa-miR-382brainGAAGUUGUUCGUGGUGGAUUCG
miR-500103109m8hsa-miR-500AUGCACCUGGGCAAGGAUUCUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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