Summary ?
GeneID5610
SymbolEIF2AK2
SynonymsEIF2AK1|PKR|PPP1R83|PRKR
Descriptioneukaryotic translation initiation factor 2 alpha kinase 2
ReferenceMIM:176871|HGNC:HGNC:9437|Ensembl:ENSG00000055332|HPRD:01468|
Gene typeprotein-coding
Map location2p22-p21
Pascal p-value0.002
Fetal beta0.328

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD7738010 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseAffinity Capture-WesternBioGRID10848580 
DBNLABP1 | HIP-55 | SH3P7drebrin-likeAffinity Capture-MSBioGRID17353931 
DNAJC3HP58 | P58 | P58IPK | PRKRIDnaJ (Hsp40) homolog, subfamily C, member 3-HPRD,BioGRID8576172 
EIF2AK2EIF2AK1 | MGC126524 | PKR | PRKReukaryotic translation initiation factor 2-alpha kinase 2Affinity Capture-Western
Far Western
Two-hybrid
BioGRID7568151 |10848580 
EIF2S1EIF-2 | EIF-2A | EIF-2alpha | EIF2 | EIF2Aeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDaPKR interacts with eIF2-alpha. This interaction was modeled on a demonstrated interaction between human PKR, and eIF2-alpha from an unspecified species.BIND11985496 
EIF2S1EIF-2 | EIF-2A | EIF-2alpha | EIF2 | EIF2Aeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa-HPRD11985496 
FANCCFA3 | FAC | FACC | FLJ14675Fanconi anemia, complementation group CAffinity Capture-WesternBioGRID12397061 
HIST2H2ACH2A | H2A-GL101 | H2A/q | H2AFQ | MGC74460histone cluster 2, H2acBiochemical ActivityBioGRID9447982 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID11447118 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1A-HPRD12397061 
HTTHD | IT15huntingtinPKR interacts with huntingtin mRNA.BIND11468270 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta-HPRD,BioGRID10848580 
ILF2MGC8391 | NF45 | PRO3063interleukin enhancer binding factor 2, 45kDaBiochemical ActivityBioGRID11438540 
ILF3CBTF | DRBF | DRBP76 | MMP4 | MPHOSPH4 | MPP4 | NF-AT-90 | NF110 | NF90 | NFAR | NFAR-1 | NFAR2 | TCP110 | TCP80interleukin enhancer binding factor 3, 90kDa-HPRD10400669 |10684936 
|11438536 |11438540 
ILF3CBTF | DRBF | DRBP76 | MMP4 | MPHOSPH4 | MPP4 | NF-AT-90 | NF110 | NF90 | NFAR | NFAR-1 | NFAR2 | TCP110 | TCP80interleukin enhancer binding factor 3, 90kDaAffinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid
BioGRID10320367 |10400669 
|11438536 |11438540 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD,BioGRID12473108 
METAP2MAP2 | MNPEP | p67 | p67eIF2methionyl aminopeptidase 2-HPRD,BioGRID11123929 
NPM1B23 | MGC104254 | NPMnucleophosmin (nucleolar phosphoprotein B23, numatrin)-HPRD12882984 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptideAffinity Capture-WesternBioGRID11350938 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoform-HPRD,BioGRID12138106 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoform-HPRD,BioGRID10866685 
PRKRADYT16 | HSD14 | PACT | RAXprotein kinase, interferon-inducible double stranded RNA dependent activatorPKR interacts with PACT. This interaction was modeled on a demonstrated interaction between human PKR, and PACT from an unspecified species.BIND11985496 
PRKRADYT16 | HSD14 | PACT | RAXprotein kinase, interferon-inducible double stranded RNA dependent activator-HPRD,BioGRID9687506 |11985496 
PRKRIP1C114 | FLJ13902 | FLJ40957PRKR interacting protein 1 (IL11 inducible)-HPRD,BioGRID12679338 
PTGES3P23 | TEBP | cPGESprostaglandin E synthase 3 (cytosolic)-HPRD,BioGRID11447118 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD7738010 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID9135145 |11278865 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID11350938 
STRBPDKFZp434N214 | FLJ11307 | FLJ14223 | FLJ14984 | ILF3L | MGC21529 | MGC3405 | SPNR | p74spermatid perinuclear RNA binding protein-HPRD10684936 
TARBP2LOQS | TRBP | TRBP1 | TRBP2TAR (HIV-1) RNA binding protein 2-HPRD,BioGRID7568151 |11438532 
TIRAPFLJ42305 | Mal | wyatttoll-interleukin 1 receptor (TIR) domain containing adaptor protein-HPRD11526399 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID10348343 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA RANKL PATHWAY 1413All SZGR 2.0 genes in this pathway
BIOCARTA RNA PATHWAY 109All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY 2726All SZGR 2.0 genes in this pathway
BIOCARTA EIF2 PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY 3731All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY 4333All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 4837All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES 6645All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN 7038All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 13582All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
EINAV INTERFERON SIGNATURE IN CANCER 2716All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS DN 5034All SZGR 2.0 genes in this pathway
YAN ESCAPE FROM ANOIKIS 2419All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY DN 4430All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176115All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 UP 1510All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 DN 3222All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 6447All SZGR 2.0 genes in this pathway
GRANDVAUX IFN RESPONSE NOT VIA IRF3 1410All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 5036All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 10267All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 7657All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR DN 2515All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN 4430All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP 8864All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS 3121All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 7149All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
WU HBX TARGETS 2 DN 1611All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
WU HBX TARGETS 1 DN 2314All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244151All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 12375All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 7148All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1 6741All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5 4636All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN 4531All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS 1613All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 7848All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway