SZGR2

Summary ?

GeneID	5610
Symbol	EIF2AK2
Synonyms	EIF2AK1\|PKR\|PPP1R83\|PRKR
Description	eukaryotic translation initiation factor 2 alpha kinase 2
Reference	MIM:176871\|HGNC:HGNC:9437\|Ensembl:ENSG00000055332\|HPRD:01468\|
Gene type	protein-coding
Map location	2p22-p21
Pascal p-value	0.002
Fetal beta	0.328

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	-	HPRD	7738010
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	Affinity Capture-Western	BioGRID	10848580
DBNL	ABP1 \| HIP-55 \| SH3P7	drebrin-like	Affinity Capture-MS	BioGRID	17353931
DNAJC3	HP58 \| P58 \| P58IPK \| PRKRI	DnaJ (Hsp40) homolog, subfamily C, member 3	-	HPRD,BioGRID	8576172
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	Affinity Capture-Western Far Western Two-hybrid	BioGRID	7568151 \|10848580
EIF2S1	EIF-2 \| EIF-2A \| EIF-2alpha \| EIF2 \| EIF2A	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	PKR interacts with eIF2-alpha. This interaction was modeled on a demonstrated interaction between human PKR, and eIF2-alpha from an unspecified species.	BIND	11985496
EIF2S1	EIF-2 \| EIF-2A \| EIF-2alpha \| EIF2 \| EIF2A	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	-	HPRD	11985496
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	Affinity Capture-Western	BioGRID	12397061
HIST2H2AC	H2A \| H2A-GL101 \| H2A/q \| H2AFQ \| MGC74460	histone cluster 2, H2ac	Biochemical Activity	BioGRID	9447982
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	11447118
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD	12397061
HTT	HD \| IT15	huntingtin	PKR interacts with huntingtin mRNA.	BIND	11468270
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	-	HPRD,BioGRID	10848580
ILF2	MGC8391 \| NF45 \| PRO3063	interleukin enhancer binding factor 2, 45kDa	Biochemical Activity	BioGRID	11438540
ILF3	CBTF \| DRBF \| DRBP76 \| MMP4 \| MPHOSPH4 \| MPP4 \| NF-AT-90 \| NF110 \| NF90 \| NFAR \| NFAR-1 \| NFAR2 \| TCP110 \| TCP80	interleukin enhancer binding factor 3, 90kDa	-	HPRD	10400669 \|10684936 \|11438536 \|11438540
ILF3	CBTF \| DRBF \| DRBP76 \| MMP4 \| MPHOSPH4 \| MPP4 \| NF-AT-90 \| NF110 \| NF90 \| NFAR \| NFAR-1 \| NFAR2 \| TCP110 \| TCP80	interleukin enhancer binding factor 3, 90kDa	Affinity Capture-Western Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	10320367 \|10400669 \|11438536 \|11438540
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	12473108
METAP2	MAP2 \| MNPEP \| p67 \| p67eIF2	methionyl aminopeptidase 2	-	HPRD,BioGRID	11123929
NPM1	B23 \| MGC104254 \| NPM	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	-	HPRD	12882984
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	Affinity Capture-Western	BioGRID	11350938
PPP1CA	MGC15877 \| MGC1674 \| PP-1A \| PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	-	HPRD,BioGRID	12138106
PPP2R5A	B56A \| MGC131915 \| PR61A	protein phosphatase 2, regulatory subunit B', alpha isoform	-	HPRD,BioGRID	10866685
PRKRA	DYT16 \| HSD14 \| PACT \| RAX	protein kinase, interferon-inducible double stranded RNA dependent activator	PKR interacts with PACT. This interaction was modeled on a demonstrated interaction between human PKR, and PACT from an unspecified species.	BIND	11985496
PRKRA	DYT16 \| HSD14 \| PACT \| RAX	protein kinase, interferon-inducible double stranded RNA dependent activator	-	HPRD,BioGRID	9687506 \|11985496
PRKRIP1	C114 \| FLJ13902 \| FLJ40957	PRKR interacting protein 1 (IL11 inducible)	-	HPRD,BioGRID	12679338
PTGES3	P23 \| TEBP \| cPGES	prostaglandin E synthase 3 (cytosolic)	-	HPRD,BioGRID	11447118
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD	7738010
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	9135145 \|11278865
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	11350938
STRBP	DKFZp434N214 \| FLJ11307 \| FLJ14223 \| FLJ14984 \| ILF3L \| MGC21529 \| MGC3405 \| SPNR \| p74	spermatid perinuclear RNA binding protein	-	HPRD	10684936
TARBP2	LOQS \| TRBP \| TRBP1 \| TRBP2	TAR (HIV-1) RNA binding protein 2	-	HPRD,BioGRID	7568151 \|11438532
TIRAP	FLJ42305 \| Mal \| wyatt	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	-	HPRD	11526399
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	10348343

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA RANKL PATHWAY	14	13	All SZGR 2.0 genes in this pathway
BIOCARTA RNA PATHWAY	10	9	All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY	27	26	All SZGR 2.0 genes in this pathway
BIOCARTA EIF2 PATHWAY	11	8	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY	48	37	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN	70	38	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP	182	110	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP	157	91	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP	194	122	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN	281	186	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP	135	82	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP	211	136	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5	147	89	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS	58	45	All SZGR 2.0 genes in this pathway
EINAV INTERFERON SIGNATURE IN CANCER	27	16	All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS DN	50	34	All SZGR 2.0 genes in this pathway
YAN ESCAPE FROM ANOIKIS	24	19	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY DN	44	30	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP	176	115	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 UP	15	10	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX4 DN	32	22	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN	64	47	All SZGR 2.0 genes in this pathway
GRANDVAUX IFN RESPONSE NOT VIA IRF3	14	10	All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP	50	36	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP	52	40	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP	87	58	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN	76	57	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR DN	25	15	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN	44	30	All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP	88	64	All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS	31	21	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP	71	49	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
WU HBX TARGETS 2 DN	16	11	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
WU HBX TARGETS 1 DN	23	14	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES	68	44	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP	71	48	All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G1	67	41	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5	46	36	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN	249	165	All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN	45	31	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN	315	201	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN	235	144	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN	204	114	All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP	364	236	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS	16	13	All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE	78	48	All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS	95	54	All SZGR 2.0 genes in this pathway

Gene Page: EIF2AK2