Gene Page: RELN

Summary
GeneID  5649
Symbol  RELN
Synonyms  PRO1598|RL
Description  reelin
See related  HGNC:9957|MIM:600514|Ensembl:ENSG00000189056|HPRD:02742|
Locus tag  -
Gene type  protein-coding
Map location  7q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AL161668.20.840.85
ERBB20.840.84
GNA120.840.84
ARAF0.820.79
HEATR20.810.77
SMO0.810.77
ASAP30.810.76
ZNF6870.800.74
CHST140.800.79
PAK40.800.77
Top 10 negatively co-expressed genes
AF347015.21-0.40-0.46
C5orf53-0.39-0.37
SYCP3-0.37-0.40
LY96-0.37-0.45
CLEC2B-0.36-0.42
SPHAR-0.36-0.47
RERGL-0.36-0.42
GPR160-0.36-0.39
KMO-0.35-0.36
AF347015.27-0.35-0.36
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DAB1-disabled homolog 1 (Drosophila)-HPRD11137154 
LRP8APOER2 | HSZ75190 | MCI1low density lipoprotein receptor-related protein 8, apolipoprotein e receptor-HPRD,BioGRID10571240 |12167620 
|12670700 |12899622 
PCDHA4CNR1 | CNRN1 | CRNR1 | MGC138307 | MGC142169 | PCDH-ALPHA4protocadherin alpha 4-HPRD10612399 
PCDHA6CNR2 | CNRN2 | CNRS2 | CRNR2 | PCDH-ALPHA6protocadherin alpha 6-HPRD10612399 
RELNPRO1598 | RLreelin-HPRD,BioGRID12135781 
VLDLRCHRMQ1 | FLJ35024 | VLDLRCHvery low density lipoprotein receptor-HPRD10571240 |10571241 
Affinity Capture-Western
Reconstituted Complex		BioGRID10571241 |12670700 
|12899622 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ECM_RECEPTOR_INTERACTION 8453All SZGR genes in this pathway
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
PID_LIS1_PATHWAY 2822All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP 13680All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
WANG_BARRETTS_ESOPHAGUS_AND_ESOPHAGUS_CANCER_DN 3722All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK 7444All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP 10075All SZGR genes in this pathway
KANG_GIST_WITH_PDGFRA_UP 5027All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_DN 5529All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP 8657All SZGR genes in this pathway
CHESLER_BRAIN_D6MIT150_QTL_TRANS 97All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP 13187All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
WANG_LSD1_TARGETS_UP 2414All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN 274165All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP 3826All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_DN 4022All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN 4934All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_UP 4025All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
HOFFMANN_SMALL_PRE_BII_TO_IMMATURE_B_LYMPHOCYTE_DN 5033All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_DN 5036All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_DN 6938All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5 3022All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
CHANGOLKAR_H2AFY_TARGETS_DN 4026All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_UP 266142All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
NABA_ECM_GLYCOPROTEINS 19699All SZGR genes in this pathway
NABA_CORE_MATRISOME 275148All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1281561631A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1389029091A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-15/16/195/424/497507513m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-205961021Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2183013081A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-271571641A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-34/4497787841Ahsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-37882881Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-5445365431A,m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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