SZGR2

Summary ?

GeneID	6774
Symbol	STAT3
Synonyms	ADMIO\|APRF\|HIES
Description	signal transducer and activator of transcription 3 (acute-phase response factor)
Reference	MIM:102582\|HGNC:HGNC:11364\|Ensembl:ENSG00000168610\|HPRD:00026\|Vega:OTTHUMG00000150645
Gene type	protein-coding
Map location	17q21.31
Pascal p-value	0.128
Sherlock p-value	0.172
Fetal beta	-1.162
DMG	1 (# studies)
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
CV:PheWAS	Phenome-wide association studies (PheWAS)	157 SNPs associated with schizophrenia	1
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	2
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.046

Section I. Genetics and epigenetics annotation

CV:PheWAS

SNP ID	Chromosome	Position	Allele	P	Function	Gene	Up/Down Distance
rs744166	17	40514201	null	1.495	STAT3	null

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg13053608	17	40345673	STAT3	1.15E-5	-3.526		DMG:vanEijk_2014
cg25687894	17	40075716	STAT3	3.09E-5	-5.732		DMG:vanEijk_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs16859370	chr2	172240162	STAT3	6774		0.13		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SPG20	0.87	0.82
ATG4C	0.87	0.85
RNF13	0.87	0.85
LAMP2	0.85	0.85
LIPA	0.85	0.85
MOSPD2	0.85	0.77
REEP3	0.84	0.78
TTC35	0.84	0.88
KIAA0494	0.83	0.82
GCLC	0.82	0.82

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SH2B2	-0.51	-0.57
SH3BP2	-0.50	-0.54
HYAL2	-0.49	-0.56
TRAF4	-0.47	-0.51
CCDC28B	-0.46	-0.53
KIAA1949	-0.46	-0.39
C21orf30	-0.46	-0.38
WDR86	-0.46	-0.47
ISLR2	-0.45	-0.28
PAFAH1B3	-0.45	-0.43

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	IEA		-
GO:0003700	transcription factor activity	IEA		-
GO:0003700	transcription factor activity	TAS		7512451 \|8675499
GO:0005062	hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity	TAS		7512451
GO:0005509	calcium ion binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0008134	transcription factor binding	IPI		15664994
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	TAS	neurite (GO term level: 5)	10205054
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS		8675499
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0007259	JAK-STAT cascade	TAS		15664994
GO:0007165	signal transduction	IEA		-
GO:0007165	signal transduction	TAS		7512451 \|10205054
GO:0006928	cell motion	TAS		9670957
GO:0019221	cytokine-mediated signaling pathway	NAS		15664994
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IDA		12444102
GO:0005634	nucleus	IEA		-
GO:0005730	nucleolus	IDA		18029348
GO:0005737	cytoplasm	TAS		7512451

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
A2M	CPAMD5 \| DKFZp779B086 \| FWP007 \| S863-7	alpha-2-macroglobulin	An unspecified isoform of STAT3 binds APRE.	BIND	15950906
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	11751884
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	basic helix-loop-helix domain containing, class B, 2	-	HPRD	15223310
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	basic helix-loop-helix domain containing, class B, 2	STRA13 interacts with STAT3-beta.	BIND	15223310
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	basic helix-loop-helix domain containing, class B, 2	STRA13 interacts with STAT3-alpha.	BIND	15223310
BMX	ETK \| PSCTK2 \| PSCTK3	BMX non-receptor tyrosine kinase	-	HPRD,BioGRID	10688651
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD	11163768
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	An unspecified isoform of STAT3 binds to Cyclin D1 promoter.	BIND	15950906
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	-	HPRD,BioGRID	11279133
CCR2	CC-CKR-2 \| CCR2A \| CCR2B \| CD192 \| CKR2 \| CKR2A \| CKR2B \| CMKBR2 \| MCP-1-R	chemokine (C-C motif) receptor 2	Affinity Capture-Western	BioGRID	11350939
CCR5	CC-CKR-5 \| CCCKR5 \| CD195 \| CKR-5 \| CKR5 \| CMKBR5	chemokine (C-C motif) receptor 5	Affinity Capture-Western	BioGRID	11350939
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD,BioGRID	10764767
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Affinity Capture-Western	BioGRID	11239394
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Stat3 was acetylated by CBP. This interaction was modeled on a demonstrated interaction between human Stat3 and CBP from an unspecified species.	BIND	15653507
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Affinity Capture-Western	BioGRID	10358079 \|15485908
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Tyrosine phophorylated EGFR interacts with STAT3.	BIND	12873986
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD,BioGRID	11350938
ELP2	FLJ10879 \| SHINC-2 \| STATIP1 \| StIP	elongation protein 2 homolog (S. cerevisiae)	-	HPRD,BioGRID	10954736
EP300	KAT3B \| p300	E1A binding protein p300	Stat3 interacts with p300.	BIND	15653507
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	10205054
EPHA5	CEK7 \| EHK1 \| HEK7 \| TYRO4	EPH receptor A5	Affinity Capture-Western	BioGRID	15485908
ERBB2	CD340 \| HER-2 \| HER-2/neu \| HER2 \| NEU \| NGL \| TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Affinity Capture-Western	BioGRID	11940572
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Affinity Capture-Western	BioGRID	11429412
FER	TYK3	fer (fps/fes related) tyrosine kinase	-	HPRD	10878010
FER	TYK3	fer (fps/fes related) tyrosine kinase	-	HPRD	10878010 \|12738762
FES	FPS	feline sarcoma oncogene	-	HPRD,BioGRID	9714332
FOS	AP-1 \| C-FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	An unspecified isoform of STAT3 binds to c-fos promoter.	BIND	15950906
FOXM1	FKHL16 \| FOXM1B \| HFH-11 \| HFH11 \| HNF-3 \| INS-1 \| MPHOSPH2 \| MPP-2 \| MPP2 \| PIG29 \| TGT3 \| TRIDENT	forkhead box M1	-	HPRD	11861839
FRAP1	FLJ44809 \| FRAP \| FRAP2 \| MTOR \| RAFT1 \| RAPT1	FK506 binding protein 12-rapamycin associated protein 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10660304 \|15522880
GHR	GHBP	growth hormone receptor	-	HPRD,BioGRID	8923468
GTF2I	BAP-135 \| BAP135 \| BTKAP1 \| DIWS \| FLJ38776 \| FLJ56355 \| IB291 \| SPIN \| TFII-I \| WBS \| WBSCR6	general transcription factor II, i	-	HPRD,BioGRID	9584171
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	Stat3 interacts with HDAC1.	BIND	15653507
HDAC2	RPD3 \| YAF1	histone deacetylase 2	Stat3 interacts with HDAC2.	BIND	15653507
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	Stat3 interacts with HDAC3.	BIND	15653507
HNF1A	HNF1 \| LFB1 \| MODY3 \| TCF1	HNF1 homeobox A	-	HPRD,BioGRID	11134330
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	12559950
IFNAR1	AVP \| IFN-alpha-REC \| IFNAR \| IFNBR \| IFRC	interferon (alpha, beta and omega) receptor 1	-	HPRD,BioGRID	8626489
IL1RAP	C3orf13 \| FLJ37788 \| IL-1RAcP \| IL1R3	interleukin 1 receptor accessory protein	-	HPRD,BioGRID	9923604
IL23R	-	interleukin 23 receptor	-	HPRD	12023369
IL2RA	CD25 \| IDDM10 \| IL2R \| TCGFR	interleukin 2 receptor, alpha	-	HPRD	10602027
IL2RB	CD122 \| P70-75	interleukin 2 receptor, beta	-	HPRD,BioGRID	10602027
IL6R	CD126 \| IL-6R-1 \| IL-6R-alpha \| IL6RA \| MGC104991	interleukin 6 receptor	-	HPRD,BioGRID	10982829
IL6ST	CD130 \| CDw130 \| GP130 \| GP130-RAPS \| IL6R-beta	interleukin 6 signal transducer (gp130, oncostatin M receptor)	-	HPRD,BioGRID	12361954
IL6ST	CD130 \| CDw130 \| GP130 \| GP130-RAPS \| IL6R-beta	interleukin 6 signal transducer (gp130, oncostatin M receptor)	gp130 interacts with an unspecified isoform of Stat3.	BIND	12361954
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	11722592
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD	10925297
JAK3	JAK-3 \| JAK3_HUMAN \| JAKL \| L-JAK \| LJAK	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	-	HPRD,BioGRID	10037026
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	10490649
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	-	HPRD,BioGRID	12551922
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD,BioGRID	11585385
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD	10825200
LEP	FLJ94114 \| OB \| OBS	leptin	Reconstituted Complex	BioGRID	12824284
LEPR	CD295 \| OBR	leptin receptor	-	HPRD	8608603
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	-	HPRD,BioGRID	9440692
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD,BioGRID	12947115
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD,BioGRID	11773079
NDUFA13	B16.6 \| CDA016 \| CGI-39 \| GRIM-19 \| GRIM19	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	GRIM-19 interacts with Stat3.	BIND	12628925
NDUFA13	B16.6 \| CDA016 \| CGI-39 \| GRIM-19 \| GRIM19	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	-	HPRD,BioGRID	12867595
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD,BioGRID	12057007
NLK	DKFZp761G1211 \| FLJ21033	nemo-like kinase	-	HPRD	15764709
NMI	-	N-myc (and STAT) interactor	Nmi interacts with Stat3	BIND	9989503
NMI	-	N-myc (and STAT) interactor	-	HPRD,BioGRID	9989503
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	9388192 \|14522952
PDIA3	ER60 \| ERp57 \| ERp60 \| ERp61 \| GRP57 \| GRP58 \| HsT17083 \| P58 \| PI-PLC	protein disulfide isomerase family A, member 3	-	HPRD,BioGRID	12060494
PIAS3	FLJ14651 \| ZMIZ5	protein inhibitor of activated STAT, 3	-	HPRD	11429412 \|12804609
PIAS3	FLJ14651 \| ZMIZ5	protein inhibitor of activated STAT, 3	-	HPRD,BioGRID	11429412
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	12506013
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	An unspecified isoform of PKC-beta interacts with Stat3.	BIND	10446219
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	PKC-delta interacts with Stat3.	BIND	10446219
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Affinity Capture-Western	BioGRID	10925297
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	11594781
PTPN2	PTPT \| TC-PTP \| TCELLPTP \| TCPTP	protein tyrosine phosphatase, non-receptor type 2	-	HPRD,BioGRID	12359225
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD,BioGRID	11021801
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	12057007
RET	CDHF12 \| HSCR1 \| MEN2A \| MEN2B \| MTC1 \| PTC \| RET-ELE1 \| RET51	ret proto-oncogene	-	HPRD,BioGRID	11536047 \|12637586 \|15485908
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	-	HPRD,BioGRID	10875894
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	Affinity Capture-Western	BioGRID	10205054
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	8657134
STAP2	BKS \| FLJ20234	signal transducing adaptor family member 2	-	HPRD	12540842
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	12070153
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	Stat3 interacts with itself to form a homodimer.	BIND	15653507
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD	10825200
TRIP10	CIP4 \| HSTP \| STOT \| STP	thyroid hormone receptor interactor 10	Affinity Capture-Western Reconstituted Complex	BioGRID	15163742
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD,BioGRID	10809230
TSLP	-	thymic stromal lymphopoietin	-	HPRD	10570284 \|11418668
ZNF467	EZI \| Zfp467	zinc finger protein 467	-	HPRD	12426389

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY	67	57	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA IL6 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL10 PATHWAY	17	14	All SZGR 2.0 genes in this pathway
BIOCARTA IL22BP PATHWAY	16	12	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY	24	17	All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY	35	29	All SZGR 2.0 genes in this pathway
ST STAT3 PATHWAY	11	10	All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID IL27 PATHWAY	26	20	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY	63	54	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY	35	29	All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY	40	34	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY	44	35	All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY	47	40	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID IL23 PATHWAY	37	30	All SZGR 2.0 genes in this pathway
PID KIT PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY	33	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	19	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS	30	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	19	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME IL 6 SIGNALING	11	9	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP	183	119	All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN	62	35	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA DN	15	10	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP	293	179	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN	51	35	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP	170	114	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP	29	20	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP	181	108	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP	134	93	All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS UP	49	35	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
OZEN MIR125B1 TARGETS	25	15	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS	290	172	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS	179	105	All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK	88	62	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP	87	67	All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 UP	46	29	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER	49	30	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART VENTRICLE DN	41	28	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS UP	49	40	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS	92	68	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY UV	62	43	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN	154	101	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP	115	80	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION UP	20	14	All SZGR 2.0 genes in this pathway
MATZUK CENTRAL FOR FEMALE FERTILITY	29	25	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C	69	49	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS	289	187	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN	116	74	All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP	194	133	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP	221	120	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	1209	1215	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1208	1215	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1208	1215	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	1438	1445	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1438	1445	1A,m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-17-5p/20/93.mr/106/519.d	448	454	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-21	1946	1952	m8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	1946	1952	m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-410	2405	2412	1A,m8	hsa-miR-410	AAUAUAACACAGAUGGCCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: STAT3