Summary ?
GeneID8850
SymbolKAT2B
SynonymsCAF|P/CAF|PCAF
Descriptionlysine acetyltransferase 2B
ReferenceMIM:602303|HGNC:HGNC:8638|Ensembl:ENSG00000114166|HPRD:06780|Vega:OTTHUMG00000130481
Gene typeprotein-coding
Map location3p24
Pascal p-value0.19
Fetal beta-1.344
SupportChromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003713transcription coactivator activityIDA12435739 
GO:0004402histone acetyltransferase activityIEA-
GO:0016740transferase activityIEA-
GO:0008080N-acetyltransferase activityIEA-
GO:0042826histone deacetylase bindingIPI12887892 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006338chromatin remodelingNAS10365964 
GO:0006473protein amino acid acetylationTAS8684459 
GO:0007049cell cycleIEA-
GO:0007050cell cycle arrestTAS8684459 
GO:0008285negative regulation of cell proliferationIDA8684459 
GO:0008152metabolic processIEA-
GO:0018076N-terminal peptidyl-lysine acetylationIDA12435739 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS10891508 
GO:0005654nucleoplasmEXP11250901 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALBDKFZp779N1935 | PRO0883 | PRO0903 | PRO1341albuminPCAF interacts with the Albumin gene.BIND15616580 
ARNTLBMAL1 | BMAL1c | JAP3 | MGC47515 | MOP3 | PASD3 | TIC | bHLHe5aryl hydrocarbon receptor nuclear translocator-likeReconstituted ComplexBioGRID14645221 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onset-HPRD,BioGRID9824164 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1-HPRD,BioGRID10318892 
CDC25B-cell division cycle 25 homolog B (S. pombe)-HPRD,BioGRID11689696 
CDK8K35 | MGC126074 | MGC126075cyclin-dependent kinase 8Affinity Capture-WesternBioGRID9710619 
CLOCKKAT13D | KIAA0334 | bHLHe8clock homolog (mouse)Reconstituted ComplexBioGRID14645221 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-Western
Co-fractionation
Reconstituted Complex
BioGRID9710619 |11864601 
CTBP1BARS | MGC104684C-terminal binding protein 1CTBP1 interacts with PCAFBIND15834423 
CTBP1BARS | MGC104684C-terminal binding protein 1Biochemical ActivityBioGRID9824164 
CUX1CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75cut-like homeobox 1-HPRD,BioGRID10852958 
EP300KAT3B | p300E1A binding protein p300Biochemical ActivityBioGRID12419806 
EVI1AML1-EVI-1 | EVI-1 | MDS1-EVI1 | MGC163392 | PRDM3ecotropic viral integration site 1-HPRD,BioGRID11568182 
H3F3AH3.3A | H3F3 | MGC87782 | MGC87783H3 histone, family 3AH3F3A (Histone 3) interacts with PCAF.BIND15616580 
HIST4H4H4/p | MGC24116histone cluster 4, H4PCAF interacts with and acetylates H4. This interaction was modeled on a demonstrated interaction between PCAF and H4, both from unspecified species.BIND15992539 
HNF1AHNF1 | LFB1 | MODY3 | TCF1HNF1 homeobox A-HPRD,BioGRID10777539 
ING1p24ING1c | p33 | p33ING1 | p33ING1b | p47 | p47ING1ainhibitor of growth family, member 1-HPRD,BioGRID12015309 
IRF1IRF-1 | MARinterferon regulatory factor 1-HPRD,BioGRID10022868 |11304541 
IRF2DKFZp686F0244 | IRF-2interferon regulatory factor 2-HPRD,BioGRID10022868 |11304541 
JDP2JUNDM2Jun dimerization protein 2-HPRD12101239 
KLF13BTEB3 | FKLF2 | NSLP1 | RFLAT-1 | RFLAT1Kruppel-like factor 13-HPRD,BioGRID11748222 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD,BioGRID12068014 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-WesternBioGRID9710619 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-Western
Co-purification
Reconstituted Complex
BioGRID12660246 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD,BioGRID9296499 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3P/CAF interacts with TRAM-1.BIND9346901 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3-HPRD9445475 
NCOA4ARA70 | DKFZp762E1112 | ELE1 | PTC3 | RFGnuclear receptor coactivator 4-HPRD,BioGRID9892017 
NOTCH1TAN1 | hN1Notch homolog 1, translocation-associated (Drosophila)-HPRD10747963 
NOTCH3CADASIL | CASILNotch homolog 3 (Drosophila)-HPRD11404076 
NPAS2FLJ23138 | MGC71151 | MOP4 | PASD4 | bHLHe9neuronal PAS domain protein 2Reconstituted ComplexBioGRID14645221 
NR4A1GFRP1 | HMR | MGC9485 | N10 | NAK-1 | NGFIB | NP10 | NUR77 | TR3nuclear receptor subfamily 4, group A, member 1-HPRD,BioGRID12082103 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1-HPRD14581481 
ONECUT1HNF-6 | HNF6 | HNF6Aone cut homeobox 1-HPRD,BioGRID10811635 
PGRNR3C3 | PRprogesterone receptorPRB interacts with PCAF. This interaction is modelled on a demonstrated interaction between human PRB and PCAF from an unspecified species.BIND9223281 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaAffinity Capture-WesternBioGRID9710619 
RARANR1B1 | RARretinoic acid receptor, alphaAffinity Capture-WesternBioGRID14581481 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1pRb interacts with the acetyltransferase domain of P/CAF.BIND15044952 
RBPJCBF1 | IGKJRB | IGKJRB1 | KBF2 | MGC61669 | RBP-J | RBPJK | RBPSUH | SUH | cslrecombination signal binding protein for immunoglobulin kappa J region-HPRD,BioGRID10747963 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Affinity Capture-WesternBioGRID9710619 
SRCAPDOMO1 | EAF1 | FLJ44499 | KIAA0309 | SWR1Snf2-related CREBBP activator protein-HPRD11581372 
SUPT3HSPT3 | SPT3Lsuppressor of Ty 3 homolog (S. cerevisiae)Affinity Capture-WesternBioGRID12660246 
TACC2AZU-1 | ECTACCtransforming, acidic coiled-coil containing protein 2TACC2 interacts with pCAF.BIND14767476 
TAF5LPAF65BTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDaAffinity Capture-WesternBioGRID12660246 
TAF9AD-004 | AK6 | CGI-137 | CINAP | CIP | MGC1603 | MGC3647 | MGC5067 | MGC:1603 | MGC:3647 | MGC:5067 | TAF2G | TAFII31 | TAFII32 | TAFIID32TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDaAffinity Capture-WesternBioGRID12660246 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD,BioGRID12435739 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Biochemical ActivityBioGRID12068014 
TRRAPFLJ10671 | PAF350/400 | PAF400 | STAF40 | TR-AP | Tra1transformation/transcription domain-associated proteinAffinity Capture-WesternBioGRID11509179 |12660246 
TTF1-transcription termination factor, RNA polymerase I-HPRD,BioGRID11250901 
TWIST1ACS3 | BPES2 | BPES3 | SCS | TWIST | bHLHa38twist homolog 1 (Drosophila)-HPRD,BioGRID10025406 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factorBiochemical ActivityBioGRID11486036 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NOTCH SIGNALING PATHWAY 4735All SZGR 2.0 genes in this pathway
BIOCARTA VDR PATHWAY 127All SZGR 2.0 genes in this pathway
BIOCARTA RARRXR PATHWAY 159All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY 2520All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 4943All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY 5338All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 3023All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION 2917All SZGR 2.0 genes in this pathway
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 2416All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 4424All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4628All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1 7046All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 8964All SZGR 2.0 genes in this pathway
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY 138All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 12280All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 10364All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION INITIATION 2514All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE DN 5438All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199124All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
BERENJENO ROCK SIGNALING NOT VIA RHOA DN 4834All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
NAGY PCAF COMPONENTS HUMAN 97All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164111All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256159All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS 5335All SZGR 2.0 genes in this pathway
CHANG POU5F1 TARGETS UP 1510All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169111All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
MULLIGAN NTF3 SIGNALING VIA INSR AND IGF1R DN 136All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP 4528All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY DN 4429All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN 4026All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN 4434All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 16286All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 DN 2614All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR DN 9156All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505328All SZGR 2.0 genes in this pathway
SUBTIL PROGESTIN TARGETS 3625All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND WITH H4K20ME1 MARK 14582All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-3p114111481A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-17-5p/20/93.mr/106/519.d120126m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-181366372m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-193143201Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-200bc/42910211027m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2054204261Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-25/32/92/363/367174817551A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-27161816241Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-3p5575631Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-3305435501A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-495162616331A,m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-93.hd/291-3p/294/295/302/372/373/520119125m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU