Gene Page: KCNAB3
Summary ?
| GeneID | 9196 |
| Symbol | KCNAB3 |
| Synonyms | AKR6A9|KCNA3.1B|KCNA3B|KV-BETA-3 |
| Description | potassium voltage-gated channel subfamily A regulatory beta subunit 3 |
| Reference | MIM:604111|HGNC:HGNC:6230|Ensembl:ENSG00000170049|HPRD:04983|Vega:OTTHUMG00000108170 |
| Gene type | protein-coding |
| Map location | 17p13.1 |
| Pascal p-value | 0.012 |
| DEG p-value | DEG:Zhao_2015:p=7.02e-04:q=0.0984 |
| Fetal beta | -0.044 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum Cortex |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG:Zhao_2015 | RNA Sequencing analysis | Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07367232 | 17 | 7826266 | KCNAB3 | 9.32E-10 | -0.012 | 1.11E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SKIV2L2 | 0.94 | 0.91 |
| UBA2 | 0.92 | 0.89 |
| IPO5 | 0.92 | 0.92 |
| ZNF143 | 0.91 | 0.90 |
| DHX15 | 0.91 | 0.91 |
| GMPS | 0.91 | 0.91 |
| CUL4B | 0.91 | 0.92 |
| DNAJC18 | 0.91 | 0.91 |
| PPP1CC | 0.91 | 0.86 |
| PPAT | 0.91 | 0.88 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.71 | -0.81 |
| AF347015.31 | -0.70 | -0.81 |
| AF347015.8 | -0.69 | -0.81 |
| MT-CYB | -0.68 | -0.79 |
| AF347015.33 | -0.68 | -0.77 |
| AF347015.21 | -0.67 | -0.80 |
| AF347015.27 | -0.67 | -0.78 |
| IFI27 | -0.67 | -0.78 |
| HIGD1B | -0.66 | -0.78 |
| FXYD1 | -0.66 | -0.78 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 43 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME POTASSIUM CHANNELS | 98 | 68 | All SZGR 2.0 genes in this pathway |
| STAEGE EWING FAMILY TUMOR | 33 | 22 | All SZGR 2.0 genes in this pathway |
| RAMALHO STEMNESS UP | 206 | 118 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 7 UP | 118 | 68 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |