Found 109 literature records

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Entrez ID	Description
11108	"PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor locus on human chromosome 12q23-q24.1. These results suggest a role for PFM1 in cell differentiation and tumor suppression, remarkably consistent with the known functions of the PR-domain family."
4089	Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.
5331	Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene.
23705	TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.
4221	The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.
27086	The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.
7428	Review. The von Hippel-Lindau tumor suppressor protein regulates hypoxia-inducible gene transcription. It is a subunit of an E3 ubiquitin ligase targeting HIFalpha subunits.
5268	"Maspin, a breast tumor suppressor gene is a valuable marker of the disease progression in breast neoplasms."
57509	"identified a tumor suppressor gene named MTSG1 at chromosome 8p21.3-22, encoding a mitochondrial protein, controlling cellular proliferation"
6648	MnSOD may be a tumor suppressor gene in human pancreatic cancer
6648	MnSOD may be a tumor suppressor gene in pancreatic cancer
1029	"Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A."
1848	Results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus.
2272	"exogenous expression of FHIT in Panc-1 cells affects genes regulating cell cycle arrest and apoptosis, and these molecular changes may contribute to the tumor suppressor activity of the FHIT gene"
7428	A variety of phenotype with R161Q germline mutation of the von Hippel-Lindau tumor suppressor gene in Japanese kindred.
51741	The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
5795	"A candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype."
3621	Genetic alterations and reduced expression of tumor suppressor p33(ING1b) in human exocrine pancreatic carcinoma.
4221	that regulation of cyclin-dependent kinase inhibitor transcription by cooperative interaction between menin and MLL plays a central role in menin's activity as a tumor suppressor
9076	"This review summarizes the role of claudins in cancer and points out that claudin 1 (CLDN1) may support tumor suppressive functions in tissues such as the brain, where dramatic loss of CLDN1 expression has been demonstrated in glioblastoma multiforme."
324	This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP).
1029	Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.
7157	"data indicate that attenuation rather than complete inactivation of Rb tumor suppressor gene function, in the context of p53 inhibition, is sufficient to initiate tumorigenesis in this model of islet cell cancer"
92304	"Studies provide further evidence that HIN-1 possesses tumor suppressor functions, and that these activities may be mediated through the AKT signaling pathway."
7428	"in pancreatic cancer cells, the p38-mediated phosphorylation of HIF-1alpha contributed to the inhibition of HIF-1alpha and von Hippel-Lindau tumor suppressor protein interaction during ischemia"
5909	data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer
4221	analysis of menin's role as a tumor suppressor and binding sites of Rbbp5 and MLL1
4221	Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.
4089	These data define the expression control of an essential BM component as a novel function for the tumor suppressor Smad4.
6282	"Expression of S100A11, a putative tumor suppressor gene, is increased in the early stage of pancreatic carcinogenesis and decreased during subsequent progression to cancer."
1029	Physical and functional interaction of the p14ARF tumor suppressor with ribosomes.
4221	Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.
4089	"These results provide genetic confirmation that SMAD4 is a pancreatic ductal adenocarcinoma tumor suppressor, functioning to block the progression of KRAS(G12D)-initiated neoplasms."
4089	"Concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas."
1029	Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells.
4015	BCL2 repression by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells
5728	transcriptional down-regulation of the tumor suppressor PTEN in pancreatic adenocarcinoma if facilitated by effect of K-RAS/ERK on TGFbeta
1029	combined with screening of K-ras mutations and allelic losses of tumor suppressors p16 and DPC4 represents a very sensitive approach in screening for pancreatic malignancy.
4089	combined with screening of K-ras mutations and allelic losses of tumor suppressors p16 and DPC4 represents a very sensitive approach in screening for pancreatic malignancy.
1031	Mutational analysis of p27 (CDKN1B) and p18 (CDKN2C) in sporadic pancreatic endocrine tumors argues against tumor-suppressor function.
6794	Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).
4221	The expression changes associated with the loss of the tumor suppressor menin provide insights into the defective organogenesis observed during early embryonic development in Men1-null mouse embryos.
4221	"Here we show that menin, a protein previously characterized as an endocrine tumor suppressor and transcriptional regulator, controls islet growth in pregnant mice"
999	"in addition to the previously implicated tumor suppressor activity of E-cadherin, modified forms of this glycoprotein might also play a role in growth promotion"
3175	"ONECUT1 expression is lost in pancreatic cancer cells, suggesting a tumor suppressor function in this malignancy."
5268	Expression of the tumor suppressor gene maspin and its significance in intraductal papillary mucinous neoplasms of the pancreas.
160728	SLC5A8 may function as a tumor suppressor gene whose silencing may contribute to carcinogenesis and progression of pancreatic cancer.
3651	"PDX1 expression is lost in gastric cancers. Its effect on cell proliferation/apoptosis, migration and tumor formation in vitro and in vivo suggested that this protein functions as a putative tumor suppressor in gastric cancer."
407040	miR-34a represents a tumor suppressor gene which is inactivated by CpG methylation and subsequent transcriptional silencing in a broad range of tumors.
5727	Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice.

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