Found 148 literature records

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Entrez ID	Description
675	Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection.
406961	Altered expression of the novel tumor suppressor miR-185 may be one of the central events that leads to dysregulation of oncogenic protein Six1 in human cancers.
8289	"genes mutated in ovarian clear cell carcinoma(OCCC);data suggest PPP2R1A functions as an oncogene and ARID1A as tumor-suppressor gene; in 42 OCCCs, 7% had mutations in PPP2R1A and 57% in ARID1A; suggests aberrant chromatin remodeling contributes to OCCC"
8289	These data implicate ARID1A as a tumor-suppressor gene frequently disrupted in ovarian clear-cell and endometrioid carcinomas.
5728	"a known tumor suppressor in ovarian cancer. Confirmed that miR-21 was significantly overexpressed in human EOC tissues and cell lines. Demonstrated knockdown of miR-21 significantly increased PTEN expression, a known tumor suppressor in ovarian cancer."
672	"BRCA1 modulates the expression of hnRNPA2B1 and KHSRP involved in the processing of RNA, highlighting the complex nature of BRCA1-associated tumor suppressor function and disclosing a novel mechanism by which BRCA1 may affect transcription."
442904	implicate the miR-335 locus on 7q32.2 as the first selective metastasis suppressor and tumor initiation suppressor locus in human breast cancer
675	A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.
23705	Loss/Down-regulation of tumor suppressor in lung cancer 1 expression is associated with ovarian tumor progression
6416	These results indicated that MKK4 acts as a tumor suppressor and may represent an important therapeutic target for the treatment of ovarian cancer
4089	"Aberrant TGF??/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer."
6416	Analysis of the mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer.
9077	The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.
8289	ARID1A is a bona fide tumor suppressor that collaborates with p53 to regulate CDKN1A and SMAD3 transcription and tumor growth in gynecologic cancers.
25898	these data reveal the in vivo roles of Pirh2 in the regulation of p53 and c-Myc stability and support its role as a tumor suppressor
5889	unravel the critical role of RAD51C in the FA pathway of ICL repair and as a tumor suppressor.
406892	Low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human epithelial ovarian cancer.
5276	Notable genes include hypoxia and tumor growth regulator Loxl2 [26] and tumor suppressor Serpini2.
6424	These results support a role for SFRP4 as a tumor suppressor gene in ovarian cancers.
7965	"AIMP2-DX2, a splicing variant of tumor suppressor AIMP2, can be a therapeutic target to control chemoresistant epithelial ovarian cancer ."
10768	"conclude that AHCYL1 expression is associated with ovarian carcinogenesis as an oncogene in chickens, whereas it plays the role of tumor suppressor in human EOC, suggesting a paradoxical function of AHCYL1 in ovarian carcinogenesis"
2100	"findings unveil a potential tumor-suppressor role of ERbeta in ovarian carcinogenesis, which could be of potential clinical relevance for the selection of the most appropriate treatment for patients"
6297	"c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor."
10424	"It deserves further examination as data point to a role of PGRMC2 as tumor suppressor, migration inhibitor and regulator of cytochrome P450 proteins."
6498	These data strongly suggest that SnoN can function as a tumor suppressor at early stages of tumorigenesis in human cancer tissues.
51330	"TWEAK/Fn14, by activating macrophages, could be ovarian tumor suppressors."
8742	"TWEAK/Fn14, by activating macrophages, could be ovarian tumor suppressors."
79648	"in addition to its role in brain development, MCPH1 also functions as a tumor suppressor gene and is regulated by miR-27a"
4486	"the function of RON in tumors may be multidimensional, not just as a tumor suppressor or oncogene."
5241	"these findings support a role for PR as a tumor suppressor in ovarian cancer cells, which exhibits inhibitory effects by inducing FOXO1-dependent cellular senescence."
407046	miR-9 plays a role as a tumor suppressor in OSC by suppressing TLN1 expression.
407047	miR-9 plays a role as a tumor suppressor in OSC by suppressing TLN1 expression.
406937	"this study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor."
406989	"These observations support hsa-miR-206 as a tumor suppressor in melanoma and identify Cyclin C, Cyclin D1, and CDK4 as miR-206 targets."
406942	"miR-150 may function as a tumor suppressor and modulate epithelial ovarian cancer cell proliferation, and invasion by directly and negatively regulating ZEB1."
10253	This study reveals the loss of SPRY2 in HGSC and indicates an important tumor-suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression.
7982	Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene.
1801	"Identification of two candidate tumor suppressor genes on chromosome 17p13.3. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCA1 and OVCA2, that map to 17p13.3."
672	Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts.
1026	The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
672	The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
7157	The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
1601	"DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer."
5796	Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2-q22.3.
7251	Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers.
672	Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
675	Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
9077	"NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas."

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