Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
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Found 616 literature records
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Entrez ID
Description
5071
analysis of Parkin protein expression with antibodies revealed that most of the ovarian cancer cell lines and primary tumors had diminished or absent Parkin expression and it is suggested it may be a tumor suppressor gene
91768
ik3-1/Cables has been identified to be a candidate tumor suppressor for colon and head/neck cancers.
10395
DLC-1 plays a role in non-small cell lung carcinoma by acting as a bona fide new tumor suppressor gene.
7490
Inhibition of breast cancer cell growth by the Wilms' tumor suppressor WT1 is associated with a destabilization of beta-catenin.
7474
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.
5654
HTRA1 is a candidate tumor suppressor in ovarian cancer.
7490
"Suppression of prostate tumor cell growth in vivo by WT1, the Wilms' tumor suppressor gene."
11186
Frequent epigenetic inactivation of the RASSF1A tumor suppressor gene in Hodgkin's lymphoma.
3090
"Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1."
1029
Cav-1 cooperates with the tumor suppressor INK4a genetic locus to prevent cell proliferation and oncogene-induced tumorigenesis
857
Cav-1 cooperates with the tumor suppressor INK4a genetic locus to prevent cell proliferation and oncogene-induced tumorigenesis
51741
The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
8651
These findings suggested that SOCS-1 may act as a tumor suppressor in at least some colorectal cancers and that SOCS-1 methylation may be a particular phenomenon related to a nearly onset of colorectal cancer.
2134
Molecular analysis of the putative tumour-suppressor gene EXTL1 in neuroblastoma patients and cell lines.
51364
"BLU, a candidate tumor suppressor gene, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma."
11334
Myristoylation is required for Fus1-mediated tumor-suppressing activity and suggest a novel mechanism for the inactivation of tumor suppressors in lung cancer.
5934
"pRb2/p130 overexpression is able to arrest cell growth in ovarian carcinoma cells, suggesting the putative role of pRb2/p130 as a tumor suppressor in this malignancy."
79893
LCRG1 is a novel gene localized to the tumor suppressor locus D17S800-D17S930 involved in laryngeal carcinoma.
5925
Docking-dependent regulation of the Rb tumor suppressor protein by Cdk4.
5268
Prognostic significance of the maspin tumor suppressor gene in pulmonary adenocarcinoma.
3621
Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nucleotide excision repair.
4087
"Differential gene expression of Smad2, a tumor suppressor gene, plays a significant role in the proliferation of breast cancer"
7071
"Differential gene expression of TIEG, a tumor suppressor gene, plays a significant role in the proliferation of breast cancer"
580
"differential gene expression of Bard1, a tumor suppressor gene, plays a significant role in the proliferation of breast cancer"
5795
"A candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype."
84700
"Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer."
23136
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
11186
Hypermethylation of the RASSF1A tumor suppressor gene is associated with clear cell renal cell carcinoma
3621
Decreased expression of the candidate tumor suppressor gene ING1 is associated with advanced neuroblastomas
2131
Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.
1029
Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene.
1474
Cystatin m: a novel candidate tumor suppressor gene for breast cancer.
9368
NHERF to be a candidate tumor suppressor gene in human breast carcinoma that may be interconnected to the SYK and MERLIN suppressors
1316
Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.
51147
"detected deletion of the ING4 locus in 10-20% of human breast cancer cell lines and primary breast tumors, supporting the possibility that ING4 might be a tumor suppressor gene"
1002
CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis
3400
ID4 gene is a potential tumor suppressor gene for which methylation status may play an important role in the CRC progression
50514
DEC1 is a candidate tumor suppressor gene that may be involved in esophageal squamous cell carcinoma development
3621
Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.
1029
Primary malignant lymphoma of the brain: frequent abnormalities and inactivation of p14 tumor suppressor gene.
1029
AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene.
11186
Inactivation of RASSF1A tumor suppressor gene by aberrant promoter hypermethylation in human pituitary adenomas.
7474
Wnt-5a serves as an antagonist to the canonical Wnt-signaling pathway with tumor suppressor activity in differentiated thyroid carcinomas.
11186
The tumor suppressor RASSF1A in human carcinogenesis: an update.
1620
likely tumor suppressor for NSCLC;silencing through homozygous deletion or methylation of its promoter promotes progression
324
Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma.
11315
"DJ-1, a novel regulator of the tumor suppressor PTEN."
5728
"DJ-1, a novel regulator of the tumor suppressor PTEN."
857
"Cav-1 functions as a tumor promoter during prostate carcinogenesis, rather than as a tumor suppressor"
1029
Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues.
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