Found 476 literature records

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Entrez ID	Description
57491	These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers.
1029	Results indicate that TBX3 represses expression of p14(ARF) tumor suppressor in breast cancer.
11200	Mutations L303X & 1100delC cause a premature termination codon preventing CHEK2 & P-Thr68 CHEK2 protein expression. CHEK2 & p53 operate in the same tumor suppressor pathway.A main CHEK2 oncogenic function involves p53-mediated G1 cell-cycle arrest.
5371	Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.
1028	The expression of CDKN1C decreases in the large majority of breast cancers and does not appear to be mediated by AI/LOH at the gene. CDKN1C may be a breast cancer tumor suppressor.
1026	BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer.
55193	BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer.
6425	In its role as tumor suppressor gene. SFRP5 methylation may be a novel DNA-based biomarker potentially useful in clinical breast cancer management.
27250	mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4
6876	"acts as a tumour suppressor; expression is lost in prostate, breast and colon cancers"
51343	Study shows a correlation between Skp2 and APC(Cdh1) in breast cancer. Cdh1 may act as an important component in tumor suppression and could be considered as a novel biomarker in breast cancer.
5925	Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure.
580	"The remarkable similarities between the mammary carcinomas of Bard1-, Brca1-, and Bard1/Brca1-mutant mice indicate that the tumor suppressor activities of both genes are mediated through the BRCA1/BARD1 heterodimer."
672	"The remarkable similarities between the mammary carcinomas of Bard1-, Brca1-, and Bard1/Brca1-mutant mice indicate that the tumor suppressor activities of both genes are mediated through the BRCA1/BARD1 heterodimer."
634	Direct interaction of tumor suppressor CEACAM1 with beta catenin: identification of key residues in the long cytoplasmic domain.
5925	Human breast cancer-associated fibroblasts show CAV1 down-regulation and RB1 tumor suppressor functional inactivation.
3394	"IRF8 was identified as a functional tumor suppressor, which is frequently silenced by epigenetic mechanism in multiple carcinomas"
51741	WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism
2100	"Pubertal physical activity up-regulates tumor suppressor genes BRCA1, p53 and ER-beta, and reduced ER-alpha/ER-beta ratio in the mammary gland"
672	"Pubertal physical activity up-regulates tumor suppressor genes BRCA1, p53 and ER-beta, and reduced ER-alpha/ER-beta ratio in the mammary gland"
7157	"Pubertal physical activity up-regulates tumor suppressor genes BRCA1, p53 and ER-beta, and reduced ER-alpha/ER-beta ratio in the mammary gland"
2066	"Pregnancy and extended lactation durations have been correlated with reduced risk of breast cancer, and the role of ErbB4 in tumor suppression may therefore be linked with its role in lactation."
10950	These data support the hypothesis that BTG3 may act to suppress tumorigenesis and that hypermethylation is an important mechanism for inactivation of BTG3 and perhaps other tumor suppressor genes.
5268	Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate.
9353	Slit-2-overexpressing breast cancer cells exhibit tumor suppressor capabilities through the novel mechanism of beta-catenin modulation.
10413	"This is the first report indicating YAP as a tumor suppressor, revealing its decreased expression in breast cancer as well as demonstrating the functional implications of YAP loss in several aspects of cancer signaling."
1030	Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex.
79648	"MDC1 and BRIT1 may function as tumor-suppressor genes, at least in part by orchestrating proper centrosome duplication and mitotic spindle assembly."
9656	"MDC1 and BRIT1 may function as tumor-suppressor genes, at least in part by orchestrating proper centrosome duplication and mitotic spindle assembly."
11178	Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis.
8313	The combination of our findings and numerous genetic and functional studies showing that APC and AXIN2 perform crucial tumor suppressor functions suggest that further investigation of the contribution of AXIN2 and APC SNPs to breast cancer risk are needed.
324	The rs454886 snp in the APC tumor suppressor gene was associated with increased breast cancer risk.
8994	study demonstrates that LIMD1 represents a novel prognostic marker for breast cancer. Combined with the fact that LIMD1 expression is downregulated in lung cancers this clearly indicates that LIMD1 may represent a critical tumor suppressor gene
4978	"OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies."
407040	miR-34a represents a tumor suppressor gene which is inactivated by CpG methylation and subsequent transcriptional silencing in a broad range of tumors.
5047	Glycodelin-induced differentiation was associated with reduced expression of oncogenes and increased expression of tumor suppressor genes. Our results suggest that glycodelin acts as a tumor suppressor in breast cancer
7490	The Wilms' tumor suppressor WT1 inhibits malignant progression of neoplastigenic mammary epithelial cells.
8314	identification of the deubiquitinating enzyme BAP1 as a tumor suppressor may lead to further understanding of how the ubiquitin proteasome system contributes to cancer and aid in the identification of new targets for cancer therapy
9365	klotho is a potential tumor suppressor and an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer
114757	"Data constitute the first direct functional evidence for CYGB, the newest member of the globin family, as a tumor suppressor gene."
54971	tumor suppressor SMAR1 downregulates Cytokeratin 8 gene expression by modulating p53-mediated transactivation of this gene
27122	Aberrant methylation of the DKK3 promoter downregulates mRNA & protein expression in human breast cancer development. It may be a tumor suppressor in normal breast tissue.
60674	"GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer."
26018	Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer.
7869	SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway.
84260	"MITOSTATIN was found within a 3.2-kb transcript for an approximately 62 kDa mitochondrial protein with tumor suppressor activity. It inhibits cell growth, is proapoptotic and downregulates Hsp27."
26038	study demonstrated the existence of somatic mutations and methylation of CHD5 in primary epithelial ovarian cancers; CHD5 may play a role as a tumor suppressor gene in ovarian cancer
54971	tumor suppressor protein SMAR1 can modulate NF-kappaB transactivation and inhibit tumorigenesis by regulating NF-kappaB target genes
6423	"SFRP2 gene is a high-frequent target of epigenetic inactivation in human breast cancer; its methylation leads to abrogation of SFRP2 expression, conferring a growth advantage to epithelial mammary cells; this supports a tumor suppressive function of SFRP2"
79633	Fat4 may be a breast tumor suppressor gene

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