Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase

Found 49 literature records

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Entrez IDDescription
3622"Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor."
2134"Recently, the EXTL1 gene, a member of the EXT tumor suppressor gene family, has been mapped to 1p36, a chromosome region which is frequently implicated in a wide variety of malignancies, including breast carcinoma, colorectal cancer and neuroblastoma. "
3621Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions.
841CASP8 may function as a tumor suppressor gene in neuroendocrine lung tumors.
7428Von Hippel-Lindau tumor suppressor protein transforms human neuroblastoma cells into functional neuron-like cells.
7157investigated whether Tat might alter p53 acetylation and p53-responsive transcription; results allude to mechanism where the HIV-1 trans-activator might impair tumor suppressor functions favoring establishment of neoplasia in AIDS
10277A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL tumor suppressor gene in the region at this stage.
23261FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate tumor suppressor genes of neuroblastoma
55735FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate tumor suppressor genes of neuroblastoma
2134Molecular analysis of the putative tumour-suppressor gene EXTL1 in neuroblastoma patients and cell lines.
3621Decreased expression of the candidate tumor suppressor gene ING1 is associated with advanced neuroblastomas
23261"Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene."
11186"Review summarizes current knowledge on genetic, epigenetic, and functional analysis of RASSF1A tumor suppressor gene and its homologues."
135138"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
5071"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
7428"Although no evidence for a classic tumor suppressor role for VHL in NB could be obtained, a strong correlation was observed between reduced levels of VHL mRNA and low patient survival probability."
29997"Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation."
407040MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells.
5789data identify PTPRD as a candidate tumor suppressor gene in cutaneous squamous cell carcinoma with a possible association with metastasis
7869High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene.
378708"These results indicate that APITD1 is not the tumor suppressor gene on 1p36 responsible for the negative prognostic effect in uveal melanoma with concurrent loss of chromosome arm 1p, region 36, and chromosome 3."
841Association of caspase-8 and Src may help reconcile why a potential tumor suppressor such as caspase-8 is rarely absent in cancers.
23095The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
83593Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma.
4771"Neurofibromatosis 2 tumor suppressor, the gene induced by valproic acid, mediates neurite outgrowth through interaction with paxillin."
407040miR-34a is a tumor suppressor gene in human neuroblastoma
26038"CHD5 is the strongest candidate tumor suppressor gene that is deleted from 1p36.31 in neuroblastomas, and inactivation of the second allele may occur by an epigenetic mechanism."
23095"KIF1Bbeta may act as a haploinsufficient tumor suppressor, and its allelic loss may be involved in the pathogenesis of neuroblastoma and other cancers."
7157MAP1B light chain can interact with the tumor suppressor p53.
23705TSLC1 acts as a candidate tumor suppressor gene for neuroblastoma.
401"PHOX2A gene, localized in a tumor suppressor candidate region at 11q, weas screened for mutations by DNA sequencing in 47 tumors of different stages."
1191"Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas."
78986DUSP26 may function as a tumour suppressor in particular cancers.
4763NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
407040MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma.
23261Findings define properties of CAMTA1 in growth suppression and neuronal differentiation that support its assignment as a 1p36 tumor suppressor gene in neuroblastoma.
27122data demonstrate that MYCN-regulated miRNAs are able to modulate the expression of the tumor suppressor DKK3 in neuroblastoma
1191"determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells"
4804"determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells"
407019"in neuroblastoma, miR-27b functions as a tumor suppressor by inhibiting the tumor-promoting function of PPARgamma, which triggers an increased inflammatory response"
4089"In vitro induction of TIAF1 self-association upregulated the expression of tumor suppressors Smad4 and WW domain-containing oxidoreductase (WOX1 or WWOX), and WOX1 in turn increased the TIAF1 expression."
406901Data suggest that miR-107 is overexpressed in pituitary adenomas and acts as a tumor suppressor; pituitary tumor suppressor gene AIP (aryl hydrocarbon receptor-interacting protein) is a miR-107 target gene; both may have roles in tumorigenesis.
574456"miR-497 is a candidate tumor suppressor in neuroblastoma, through the direct targeting of WEE1."
2735"Findings suggest an important role of Gli1 as a tumor suppressor in neuroblastoma, and offer a mechanism by which AKT2 regulates the subcellular localization, and in turn, inhibits the tumor-suppressive function of Gli1 in neuroblastoma."
27022"Results indicate that FOXD3 exhibits tumor suppressive activity that affects the growth, aggressiveness and angiogenesis of NB through transcriptional regulation of NDRG1."
574408Data indicate that overexpression of KDM1A partially reversed the tumor suppressive effects of miR-329 in neuroblastoma cells.
406957"results demonstrated that miR-181c inhibits neuroblastoma cell growth and metastasis-related traits through the suppression of Smad7, functioning as a tumor suppressor"
11197WIF-1 is downregulated and functions as a tumor suppressor by antagonizing Wnt/beta-catenin signaling in neuroblastoma.
22954Trim32 is a positive regulator of ACD that acts against MYCN and should be considered as a tumor-suppressor candidate

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