Gene Page: EFNB2

Summary
GeneID  1948
Symbol  EFNB2
Synonyms  EPLG5|HTKL|Htk-L|LERK5|MGC126226|MGC126227|MGC126228
Description  ephrin-B2
See related  HGNC:3227|MIM:600527|Ensembl:ENSG00000125266|HPRD:02754|
Locus tag  RP11-272L14.1
Gene type  protein-coding
Map location  13q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0172 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EGR20.840.86
FBXL160.820.84
ADRB10.820.77
NR4A10.800.81
EGR10.800.86
C2orf550.780.91
CYP46A10.770.87
DDN0.770.90
RAB40B0.770.80
INF20.760.73
Top 10 negatively co-expressed genes
TUBB2B-0.43-0.68
HEBP2-0.43-0.76
KIAA1949-0.42-0.60
RBMX2-0.42-0.71
DYNLT1-0.41-0.72
TRAF4-0.41-0.67
GTF3C6-0.41-0.56
UBE2L6-0.41-0.54
IDH1-0.40-0.58
YBX1-0.40-0.59
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0046875ephrin receptor bindingTAS8559144 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0001945lymph vessel developmentIEA-
GO:0007267cell-cell signalingTAS8559144 
GO:0009887organ morphogenesisIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS8660976 
GO:0005887integral to plasma membraneTAS8660976 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EPHA3ETK | ETK1 | HEK | HEK4 | TYRO4EPH receptor A3-HPRD,BioGRID8559144 
EPHA4HEK8 | SEK | TYRO1EPH receptor A4-HPRD,BioGRID12761826 
EPHB1ELK | EPHT2 | FLJ37986 | Hek6 | NETEPH receptor B1-HPRD8559144 |10066262 
The membrane bound ligand HTK-L interacts with the receptor ELK. This interaction was modeled on a demonstrated interaction between HTK-L from human and ELK from rat.BIND8755474 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2The membrane bound ligand HTK-L interacts with the receptor NUK. This interaction was modeled on a demonstrated interaction between HTK-L from human and NUK from mouse.BIND8755474 
-HPRD,BioGRID11780069 
EPHB4HTK | MYK1 | TYRO11EPH receptor B4-HPRD9718367 |12051776 
EPHB6HEP | MGC129910 | MGC129911EPH receptor B6-HPRD10648835 
NCK2GRB4 | NCKbetaNCK adaptor protein 2-HPRD12206665 
RHBDL2MGC16997 | RRP2rhomboid, veinlet-like 2 (Drosophila)-HPRD15047175 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)Ephrin-B2 interacts with ST-1. This interaction was modelled on a demonstrated interaction between human Ephrin-B2 and rat ST-1.BIND11152476 
-HPRD10473577 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY 3025All SZGR genes in this pathway
FRASOR_TAMOXIFEN_RESPONSE_UP 5136All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
VANHARANTA_UTERINE_FIBROID_UP 4526All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE 12380All SZGR genes in this pathway
KOBAYASHI_RESPONSE_TO_ROMIDEPSIN 1914All SZGR genes in this pathway
DAUER_STAT3_TARGETS_UP 4935All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP 7347All SZGR genes in this pathway
DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_UP 2819All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
HAN_JNK_SINGALING_UP 3521All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
TSENG_ADIPOGENIC_POTENTIAL_UP 3019All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
LEE_DOUBLE_POLAR_THYMOCYTE 2717All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_UP 293203All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP 166105All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_6 7548All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_UP 5541All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
THILLAINADESAN_ZNF217_TARGETS_DN 95All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_DN 213127All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_DN 8251All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_DN 4127All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
IKEDA_MIR1_TARGETS_UP 5339All SZGR genes in this pathway
LOPEZ_TRANSLATION_VIA_FN1_SIGNALING 3521All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
HOLLEMAN_VINCRISTINE_RESISTANCE_B_ALL_UP 3822All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206322732341A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-103/107302730331Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-124.118651871m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506186518711Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-129-5p17171723m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-130/30129842990m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-146211621221Ahsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-148/15229852991m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/497112511311Ahsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-153201820251A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-182301830251A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-188153015371A,m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-1929832989m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-192/215121612221Ahsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-200bc/429310131081A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-21814261432m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-324-3p29672973m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-33010961102m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-339115411601Ahsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-369-3p31033109m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3759599651Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-381291829241Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-448201920251Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-450214121471Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
hsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-494323932451Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-503112511311Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-96301930251Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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