Gene Page: EGFR

Summary
GeneID  1956
Symbol  EGFR
Synonyms  ERBB|ERBB1|HER1|PIG61|mENA
Description  epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
See related  HGNC:3236|MIM:131550|Ensembl:ENSG00000146648|HPRD:00579|
Locus tag  -
Gene type  protein-coding
Map location  7p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.8135 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NOTCH30.710.68
SYDE10.700.69
APLN0.690.62
FGFR30.680.52
NFKB20.680.67
CASKIN20.680.65
AC020763.20.680.68
INPPL10.670.65
SLC2A10.670.65
PLXNB10.650.61
Top 10 negatively co-expressed genes
TMEM70-0.47-0.48
THOC7-0.47-0.52
ZCCHC17-0.44-0.47
GLMN-0.44-0.48
AP4S1-0.44-0.48
C8orf38-0.44-0.46
BEX5-0.44-0.47
TCEAL7-0.42-0.49
C2orf80-0.42-0.44
MTIF3-0.42-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005006epidermal growth factor receptor activityIDA12435727 
GO:0005006epidermal growth factor receptor activityNAS2790960 |6325948 
GO:0004888transmembrane receptor activityIDA7736574 
GO:0003690double-stranded DNA bindingNAS6325948 
GO:0030235nitric-oxide synthase regulator activityIDA12828935 
GO:0004710MAP/ERK kinase kinase activityNAS15542601 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0051015actin filament bindingIDA14702346 
GO:0042802identical protein bindingIPI16777603 
GO:0046982protein heterodimerization activityIDA10572067 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001503ossificationNAS12925580 
GO:0007202activation of phospholipase C activityTAS12435727 
GO:0007173epidermal growth factor receptor signaling pathwayIDA12435727 
GO:0006950response to stressNAS12828935 
GO:0007166cell surface receptor linked signal transductionIDA7736574 
GO:0016337cell-cell adhesionIMP12435727 
GO:0042327positive regulation of phosphorylationIDA15082764 
GO:0050999regulation of nitric-oxide synthase activityIDA12828935 
GO:0051205protein insertion into membraneTAS12435727 
GO:0030335positive regulation of cell migrationIMP12435727 
GO:0043406positive regulation of MAP kinase activityIDA10572067 
GO:0043006calcium-dependent phospholipase A2 activationTAS12435727 
GO:0050679positive regulation of epithelial cell proliferationIDA10572067 
GO:0050730regulation of peptidyl-tyrosine phosphorylationIMP12435727 
GO:0045786negative regulation of cell cycleIEA-
GO:0046777protein amino acid autophosphorylationIEA-
GO:0045429positive regulation of nitric oxide biosynthetic processIDA12828935 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceNAS9103388 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA12828935 
GO:0005737cytoplasmIDA12435727 
GO:0005768endosomeIDA14702346 
GO:0005783endoplasmic reticulumIDA18029348 
GO:0030122AP-2 adaptor complexTAS14702346 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP8493579 |8639530 |8845374 
|9356464 |9544989 
|10567358 |10648629 
|10734310 |10913131 
|11823423 |11894095 
|122181 
GO:0005886plasma membraneIDA15465819 
GO:0016323basolateral plasma membraneIEA-
GO:0030139endocytic vesicleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AMHMIF | MISanti-Mullerian hormone-HPRD8596488 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorAffinity Capture-Western
Co-localization		BioGRID15288768 |15305378 
AREGAR | CRDGF | MGC13647 | SDGFamphiregulin-HPRD,BioGRID10085134 
ARF4ARF2ADP-ribosylation factor 4-HPRD,BioGRID12446727 
ATP5C1ATP5C | ATP5CL1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1Two-hybridBioGRID16169070 
BTC-betacellulin-HPRD9528863 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)EGFR interacts with calmodulinBIND14960328 
CAMLGCAML | MGC163197calcium modulating ligand-HPRD,BioGRID12919676 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD,BioGRID11226410 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID9374534 
CAV3LGMD1C | LQT9 | MGC126100 | MGC126101 | MGC126129 | VIP-21 | VIP21caveolin 3-HPRD,BioGRID9374534 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceAffinity Capture-WesternBioGRID10086340 |12061819 
-HPRD8662998 
An unspecified isoform of EGFR interacts with CBL.BIND15735736 
c-Cbl ubiquitinates an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between c-Cbl and EGFR, both from an unspecified species.BIND12234920 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence b-HPRD,BioGRID10086340 
CBLCCBL-3 | CBL-SL | RNF57Cas-Br-M (murine) ecotropic retroviral transforming sequence c-HPRD,BioGRID10362357 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1An unspecified isoform of EGFR binds to Cyclin D1 promoter.BIND15950906 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)CD44 interacts with EGFR.BIND12093135 
-HPRD,BioGRID12093135 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD,BioGRID10985391 
CDC25ACDC25A2cell division cycle 25 homolog A (S. pombe)-HPRD,BioGRID11912208 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)EGFR interacts with E-cadherinBIND14681060 
-HPRD,BioGRID10969083 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID12095417 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD,BioGRID9642287 
CSKMGC117393c-src tyrosine kinaseAffinity Capture-MSBioGRID16729043 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD,BioGRID9233779 
CTNND1CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120catenin (cadherin-associated protein), delta 1Reconstituted ComplexBioGRID9535896 
DCNCSCD | DSPG2 | PG40 | PGII | PGS2 | SLRR1Bdecorin-HPRD,BioGRID9988678 |12105206 
DEGS1DEGS | DES1 | Des-1 | FADS7 | MGC5079 | MIG15 | MLDdegenerative spermatocyte homolog 1, lipid desaturase (Drosophila)-HPRD9188692 
DOK2p56DOK | p56dok-2docking protein 2, 56kDa-HPRD,BioGRID10508618 
DUSP3VHRdual specificity phosphatase 3Biochemical ActivityBioGRID1281549 
EGFHOMG4 | URGepidermal growth factor (beta-urogastrone)-HPRD10788520 |12093292 
|12620237|12093292 
EGF interacts with EGFR.BIND15837620 
-HPRD,BioGRID12093292 
EGFR interacts with EGF. This interaction was modelled on a demonstrated interaction between EGFR from human and EGF from mouse.BIND8413296 
An unspecified isoform of EGFR interacts with EGF.BIND15950906 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)EGFR interacts with EGFR.BIND15284455 
Affinity Capture-WesternBioGRID14576349 
EPPK1EPIPL | EPIPL1epiplakin 1-HPRD12577067 
EPS15AF-1P | AF1P | MLLT5epidermal growth factor receptor pathway substrate 15-HPRD,BioGRID9049247 
EPS8-epidermal growth factor receptor pathway substrate 8-HPRD7532293 |12127568 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD11500850 
EGFR interacts with ErbB2.BIND15652750 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD,BioGRID10527633 
EREGERepiregulin-HPRD,BioGRID9419975 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1-HPRD,BioGRID11887937 
FERTYK3fer (fps/fes related) tyrosine kinase-HPRD,BioGRID7623846 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homologAn unspecified isoform of EGFR binds to c-fos promoter.BIND15950906 
GAB1-GRB2-associated binding protein 1-HPRD,BioGRID11432805 
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2-HPRD11286993 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10Grb10 interacts with EGFR.BIND9506989 
-HPRD,BioGRID9006901 |9506989 
GRB14-growth factor receptor-bound protein 14-HPRD,BioGRID8647858 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2GRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR.BIND15782189 
-HPRD1322798 |7527043 
EGFR interacts with GRB2.BIND8305738 
Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID1322798 |7510700 
|7527043 |8647858 
|9050991 |10026169 
|10085134 |11960376 
|12577067 |16729043 
GRB7-growth factor receptor-bound protein 7-HPRD9710451 
HBEGFDTR | DTS | DTSF | HEGFLheparin-binding EGF-like growth factor-HPRD,BioGRID12725245 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1EGFR interacts with Hsp90. This interaction was modeled on a demonstrated interaction between EGFR from an unspecified species and human Hsp90.BIND12471035 
HTTHD | IT15huntingtin-HPRD,BioGRID9079622 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptorAffinity Capture-WesternBioGRID17047074 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1-HPRD,BioGRID11349134 
ITGA5CD49e | FNRA | VLA5Aintegrin, alpha 5 (fibronectin receptor, alpha polypeptide)-HPRD10888683 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)Affinity Capture-WesternBioGRID10358079 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobinReconstituted ComplexBioGRID9535896 
KRT17K17 | PC | PC2 | PCHC1keratin 17-HPRD12577067 
KRT18CYK18 | K18keratin 18-HPRD12577067 
KRT7CK7 | K2C7 | K7 | MGC129731 | MGC3625 | SCLkeratin 7-HPRD12577067 
KRT8CARD2 | CK8 | CYK8 | K2C8 | K8 | KOkeratin 8-HPRD12577067 
LRSAM1FLJ31641 | RIFLE | TALleucine rich repeat and sterile alpha motif containing 1Affinity Capture-WesternBioGRID15256501 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD,BioGRID11116146 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1-HPRD,BioGRID9346925 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14Biochemical ActivityBioGRID7535770 
MUC1CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUMmucin 1, cell surface associated-HPRD,BioGRID11278868 |11483589 
MUC1 interacts with and is tyrosine-phosphorylated by EGFR.BIND11483589 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID9362449 
NCK2GRB4 | NCKbetaNCK adaptor protein 2Affinity Capture-Western
Reconstituted Complex		BioGRID9737977 |10026169 
-HPRD1333047 |9737977 
NRG1ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDFneuregulin 1Affinity Capture-WesternBioGRID7730382 
-HPRD8702572 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1Tyrosine-phosphorylated EGFR interacts with PAK1.BIND12522133 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptide-HPRD,BioGRID9506992 
PIK3C2BC2-PI3K | DKFZp686G16234phosphoinositide-3-kinase, class 2, beta polypeptide-HPRD,BioGRID11533253 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD8662998 
EGFR interacts with p85. This interaction was modeled on a demonstrated interaction between human EGFR and bovine p85.BIND1372092 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)Tyrosine phosphorlyated EGFR interacts with p85-beta.BIND11172806 
PITPNAMGC99649 | PITPN | VIB1Aphosphatidylinositol transfer protein, alpha-HPRD,BioGRID7761838 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID9207933 
EGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human EGFR and bovine PLC-gamma.BIND2173144 |2176151 
PLD2-phospholipase D2-HPRD,BioGRID9837959 
EGFR interacts with PLD1. This interaction was modelled on a demonstrated interaction between human EGFR and mouse PLD2.BIND9837959 
PLEC1EBS1 | EBSO | HD1 | PCN | PLEC1b | PLTNplectin 1, intermediate filament binding protein 500kDa-HPRD12577067 
PLSCR1MMTRA1Bphospholipid scramblase 1-HPRD,BioGRID12009895 
-HPRD12009895 |12871937 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alpha-HPRD,BioGRID9050991 
PRKAR1ACAR | CNC | CNC1 | DKFZp779L0468 | MGC17251 | PKR1 | PPNAD1 | PRKAR1 | TSE1protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)-HPRD,BioGRID9050991 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID12878187 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID10806474 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID10777553 
PTK6BRK | FLJ42088PTK6 protein tyrosine kinase 6-HPRD,BioGRID8940083 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID7540771 |8621392 
|10889023 |12573287 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID7673163 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID9733788 
PTPRJCD148 | DEP1 | HPTPeta | R-PTP-ETA | SCC1protein tyrosine phosphatase, receptor type, J-HPRD9115287 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1Reconstituted ComplexBioGRID8647858 
GAP interacts with EGFR.BIND1385407 |1850098 
|2176151 
-HPRD1633149 
RGS16A28-RGS14 | A28-RGS14P | RGS-Rregulator of G-protein signaling 16-HPRD,BioGRID11602604 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID11116146 
ROS1MCF3 | ROS | c-ros-1c-ros oncogene 1 , receptor tyrosine kinaseAffinity Capture-WesternBioGRID11094073 
SGSM2KIAA0397 | RUTBC1small G protein signaling modulator 2Two-hybridBioGRID16169070 
SH2D3ANSP1SH2 domain containing 3A-HPRD,BioGRID10187783 
SH3BGRLMGC117402 | SH3BGRSH3 domain binding glutamic acid-rich protein likeAffinity Capture-MSBioGRID16729043 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1Affinity Capture-WesternBioGRID11894095 |12177062 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Shc interacts with activated EGFR.BIND1623525 
ShcA interacts with EGFR.BIND8610109 
ShcA interacts with the EGFR.BIND8577769 |8610109 
|8943228 
-HPRD,BioGRID9544989 
EGF-R interacts with Shc. This interaction was modelled on a demonstrated interaction between human EGF-R and mouse Shc.BIND8887653 
SHC3N-Shc | NSHC | RAI | SHCCSHC (Src homology 2 domain containing) transforming protein 3-HPRD,BioGRID9507002 
SNRPD2SMD2 | SNRPD1small nuclear ribonucleoprotein D2 polypeptide 16.5kDa-HPRD12577067 
SNX1HsT17379 | MGC8664 | SNX1A | Vps5sorting nexin 1-HPRD,BioGRID8638121 |9819414 
SNX2MGC5204 | TRG-9sorting nexin 2-HPRD,BioGRID9819414 
SNX4-sorting nexin 4-HPRD,BioGRID9819414 
SNX6MGC3157 | MSTP010 | TFAF2sorting nexin 6-HPRD,BioGRID11279102 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD,BioGRID12070153 
SOCS3ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3suppressor of cytokine signaling 3-HPRD,BioGRID12070153 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID9447973 
SOS2FLJ25596son of sevenless homolog 2 (Drosophila)-HPRD,BioGRID10675333 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10971656 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID12070153 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Affinity Capture-WesternBioGRID10358079 |15485908 
Tyrosine phophorylated EGFR interacts with STAT3.BIND12873986 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID10358079 
STAT5BSTAT5signal transducer and activator of transcription 5B-HPRD,BioGRID10558875 
TGFATFGAtransforming growth factor, alpha-HPRD,BioGRID12297049 
TJP1DKFZp686M05161 | MGC133289 | ZO-1tight junction protein 1 (zona occludens 1)-HPRD,BioGRID12708492 
TNCHXB | MGC167029 | TNtenascin C-HPRD11470832 
TNK2ACK | ACK1 | FLJ44758 | FLJ45547 | p21cdc42Hstyrosine kinase, non-receptor, 2-HPRD8497321 |8647288 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID10938113 
VAV2-vav 2 guanine nucleotide exchange factorTyrosine phosphorylated EGFR interacts with and phosphorylates Vav2.BIND12454019 
-HPRD,BioGRID10618391 |10938113 
VAV3FLJ40431vav 3 guanine nucleotide exchange factorAffinity Capture-WesternBioGRID10938113 
-HPRD11094073 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)Affinity Capture-WesternBioGRID9307968 
XPO6EXP6 | FLJ22519 | KIAA0370 | RANBP20exportin 6-HPRD14592989 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6-HPRD9430697 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideEGFR interacts with 14-3-3-zeta.BIND15225635 
ZNF259MGC110983 | ZPR1zinc finger protein 259-HPRD8650580 |10938113|10938113 
-HPRD10938113 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_DORSO_VENTRAL_AXIS_FORMATION 2521All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION 7553All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 6844All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_ENDOMETRIAL_CANCER 5245All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY 3628All SZGR genes in this pathway
BIOCARTA_CBL_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_EGFR_SMRTE_PATHWAY 1111All SZGR genes in this pathway
BIOCARTA_MCALPAIN_PATHWAY 2516All SZGR genes in this pathway
BIOCARTA_CARDIACEGF_PATHWAY 1816All SZGR genes in this pathway
BIOCARTA_HER2_PATHWAY 2217All SZGR genes in this pathway
BIOCARTA_SPRY_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_TEL_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_TFF_PATHWAY 2115All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY 6554All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_ARF6_PATHWAY 3527All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_TELOMERASE_PATHWAY 6848All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 3529All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY 2119All SZGR genes in this pathway
PID_ERBB_NETWORK_PATHWAY 1513All SZGR genes in this pathway
PID_ERBB1_INTERNALIZATION_PATHWAY 4135All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY 4234All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY 4635All SZGR genes in this pathway
PID_SYNDECAN_3_PATHWAY 1715All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 1813All SZGR genes in this pathway
REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 2220All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_EGFR_DOWNREGULATION 2514All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 1513All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1 3425All SZGR genes in this pathway
LIU_SOX4_TARGETS_UP 13794All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN 182111All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN 198110All SZGR genes in this pathway
TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_UP 9459All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_DN 4828All SZGR genes in this pathway
NOJIMA_SFRP2_TARGETS_DN 2518All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_DN 4329All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
ELVIDGE_HYPOXIA_UP 171112All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_UP 13085All SZGR genes in this pathway
ELVIDGE_HIF1A_TARGETS_DN 9158All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 10472All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP 185119All SZGR genes in this pathway
OZANNE_AP1_TARGETS_UP 1811All SZGR genes in this pathway
APPIERTO_RESPONSE_TO_FENRETINIDE_DN 5135All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
SUZUKI_AMPLIFIED_IN_ORAL_CANCER 1612All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_29 117All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
HONRADO_BREAST_CANCER_BRCA1_VS_BRCA2 1812All SZGR genes in this pathway
SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS 3727All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_NORMAL_DN 3327All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_IMMORTALIZED_DN 3126All SZGR genes in this pathway
HASINA_NOL7_TARGETS_DN 139All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA 7038All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
COLIN_PILOCYTIC_ASTROCYTOMA_VS_GLIOBLASTOMA_DN 2821All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
JEON_SMAD6_TARGETS_DN 1914All SZGR genes in this pathway
SUNG_METASTASIS_STROMA_DN 5434All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_UP 7536All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_DN 6643All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_DN 6544All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_DN 6539All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_DN 6438All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_DN 6442All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C4 1812All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_DN 2314All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
SU_PLACENTA 3018All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_GAMMA_RADIATION 1513All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
ZHANG_GATA6_TARGETS_DN 6446All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_UP 3920All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
HUANG_DASATINIB_RESISTANCE_UP 8153All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN 14279All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_RECURRENTLY 65All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_MUTATED 88All SZGR genes in this pathway
GYORFFY_DOXORUBICIN_RESISTANCE 5634All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
NIELSEN_SCHWANNOMA_DN 189All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway
CHICAS_RB1_TARGETS_LOW_SERUM 10051All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
OHGUCHI_LIVER_HNF4A_TARGETS_DN 14985All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
ZHU_SKIL_TARGETS_UP 2014All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
SERVITJA_LIVER_HNF1A_TARGETS_DN 157105All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_3 209All SZGR genes in this pathway
PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2 7645All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
LIU_IL13_PRIMING_MODEL 1511All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_3 1612All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1282002061Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-272002071A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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