Gene Page: GTF2H4

Summary
GeneID  2968
Symbol  GTF2H4
Synonyms  TFB2|TFIIH
Description  general transcription factor IIH, polypeptide 4, 52kDa
See related  HGNC:4658|MIM:601760|Ensembl:ENSG00000213780|HPRD:03456|
Locus tag  DADB-160J14.4
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS9118947 
GO:0003702RNA polymerase II transcription factor activityIEA-
GO:0005515protein bindingIPI17466626 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000718nucleotide-excision repair, DNA damage removalEXP10583946 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006367transcription initiation from RNA polymerase II promoterEXP8946909 
GO:0006368RNA elongation from RNA polymerase II promoterEXP9405375 
GO:0006350transcriptionIEA-
GO:0006281DNA repairTAS9118947 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP1939271 |2449431 |8946909 
|9512541 |9582279 
|9790902 |10214908 
|11313499 |12393749 
|12646563 
GO:0005675holo TFIIH complexTAS9118947 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetCo-purificationBioGRID9159119 
BTAF1KIAA0940 | MGC138406 | MOT1 | TAF(II)170 | TAF172 | TAFII170BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)Co-purificationBioGRID9159119 
ERCC3BTF2 | GTF2H | RAD25 | TFIIH | XPBexcision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)-HPRD,BioGRID9118947 
GTF2BTF2B | TFIIBgeneral transcription factor IIBCo-purification
Reconstituted Complex		BioGRID9159119 
GTF2E1FE | TF2E1 | TFIIE-Ageneral transcription factor IIE, polypeptide 1, alpha 56kDaCo-purification
Reconstituted Complex		BioGRID9159119 
-HPRD11113176 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDaCo-purification
Reconstituted Complex		BioGRID9159119 
GTF2H5C6orf175 | TFB5 | TGF2H5 | TTD | TTD-A | TTDA | bA120J8.2general transcription factor IIH, polypeptide 5-HPRD,BioGRID11062469 |15220921 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-Western
Co-purification		BioGRID9159119 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaCo-purification
Reconstituted Complex		BioGRID9159119 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinCo-purification
Reconstituted Complex		BioGRID9159119 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_BASAL_TRANSCRIPTION_FACTORS 3624All SZGR genes in this pathway
KEGG_NUCLEOTIDE_EXCISION_REPAIR 4425All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION 2212All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION 8964All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION 10554All SZGR genes in this pathway
REACTOME_MRNA_CAPPING 3011All SZGR genes in this pathway
REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 4524All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 4121All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_EXCISION_REPAIR 5127All SZGR genes in this pathway
REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 4519All SZGR genes in this pathway
REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 3013All SZGR genes in this pathway
REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 12280All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 6132All SZGR genes in this pathway
REACTOME_GLOBAL_GENOMIC_NER_GG_NER 3520All SZGR genes in this pathway
REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 2311All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 3411All SZGR genes in this pathway
REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 10461All SZGR genes in this pathway
REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 2514All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
WAKASUGI_HAVE_ZNF143_BINDING_SITES 5833All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_UP 2719All SZGR genes in this pathway
ZHANG_RESPONSE_TO_CANTHARIDIN_DN 6946All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway


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