SZGR2

Summary ?

GeneID	3624
Symbol	INHBA
Synonyms	EDF\|FRP
Description	inhibin beta A
Reference	MIM:147290\|HGNC:HGNC:6066\|HPRD:00929\|
Gene type	protein-coding
Map location	7p15-p13
Pascal p-value	5.726E-5
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs6687320	chr1	37430362	INHBA	3624	0.08	trans
rs1572945	chr1	58069522	INHBA	3624	0.1	trans
rs12030788	chr1	66768128	INHBA	3624	1.609E-4	trans
rs11807500	chr1	68503525	INHBA	3624	0.06	trans
rs2014805	chr2	175165192	INHBA	3624	0.06	trans
rs7608942	chr2	182820100	INHBA	3624	0.2	trans
rs1014141	chr3	43810759	INHBA	3624	0.1	trans
rs11130012	chr3	43823179	INHBA	3624	0.05	trans
rs7615639	chr3	43852564	INHBA	3624	0.15	trans
rs17044826	chr3	66620522	INHBA	3624	0.1	trans
rs1959283	chr3	159917358	INHBA	3624	0.1	trans
rs614566	chr3	182847389	INHBA	3624	0.08	trans
rs6834153	chr4	8606484	INHBA	3624	0	trans
rs6894161	chr5	91098032	INHBA	3624	0.18	trans
rs17109939	chr5	148694416	INHBA	3624	0.03	trans
rs2056166	chr5	160448661	INHBA	3624	0.16	trans
rs11960742	chr5	173068112	INHBA	3624	0.04	trans
rs226945	chr6	3717178	INHBA	3624	0.09	trans
rs226963	chr6	3724120	INHBA	3624	0.13	trans
snp_a-2046639		0	INHBA	3624	0.01	trans
rs3888778	chr6	30529621	INHBA	3624	0.04	trans
rs2239516	chr6	30578047	INHBA	3624	0.04	trans
rs6904236	chr6	30596134	INHBA	3624	0.06	trans
rs7749235	chr6	30635592	INHBA	3624	0.17	trans
rs6457967	chr6	37002011	INHBA	3624	0.07	trans
rs10484851	chr6	38978770	INHBA	3624	0.11	trans
rs9381009	chr6	40918100	INHBA	3624	0.19	trans
rs887719	chr7	21184272	INHBA	3624	0.1	trans
rs320082	chr7	29105404	INHBA	3624	1.668E-6	trans
rs317720	chr7	29110633	INHBA	3624	3.005E-5	trans
rs317714	chr7	29115553	INHBA	3624	1.575E-7	trans
rs317724	chr7	29120565	INHBA	3624	3.005E-5	trans
rs1419793	chr7	34697630	INHBA	3624	0.03	trans
rs343083	chr7	35571887	INHBA	3624	0.03	trans
rs6942437	chr7	146798442	INHBA	3624	0.06	trans
rs12540961	chr8	9689750	INHBA	3624	0	trans
rs7829733	chr8	9691720	INHBA	3624	2.037E-4	trans
rs7013686	chr8	9715474	INHBA	3624	0.04	trans
rs4242415	chr8	24597175	INHBA	3624	0.05	trans
rs2340775	chr8	29082610	INHBA	3624	0.15	trans
rs16886605	chr8	115894398	INHBA	3624	0.14	trans
rs11203077	chr10	91097084	INHBA	3624	0	trans
rs10834670	chr11	25404015	INHBA	3624	0	trans
rs10834671	chr11	25404269	INHBA	3624	0.01	trans
rs17320769	chr11	30707634	INHBA	3624	0.08	trans
rs11019015	chr11	90157517	INHBA	3624	0.03	trans
rs17127472	chr11	123448587	INHBA	3624	0.04	trans
rs11066476	chr12	113465366	INHBA	3624	0.01	trans
rs16949584	chr12	120153747	INHBA	3624	0.19	trans
rs4497566	chr13	51694324	INHBA	3624	0.15	trans
rs2993290	chr13	113647189	INHBA	3624	1.083E-4	trans
rs11158850	chr14	70757171	INHBA	3624	4.354E-4	trans
rs17117326	chr14	73017125	INHBA	3624	0.15	trans
rs17737309	chr14	85359235	INHBA	3624	0.04	trans
rs3790050	chr14	94421666	INHBA	3624	0.11	trans
rs11072201	chr15	70857175	INHBA	3624	0.07	trans
rs7200513	chr16	17219474	INHBA	3624	0.04	trans
rs3829495	chr16	17221986	INHBA	3624	0.01	trans
rs2219403	chr17	72059030	INHBA	3624	0.07	trans
rs12452652	chr17	72235560	INHBA	3624	7.688E-6	trans
rs9646596	chr18	53049211	INHBA	3624	0.02	trans
rs17594526	chr18	53058237	INHBA	3624	0.03	trans
rs11152369	chr18	53066327	INHBA	3624	0.16	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005179	hormone activity	TAS		12456957
GO:0005125	cytokine activity	IDA		9884026
GO:0008083	growth factor activity	TAS		12324653
GO:0017106	activin inhibitor activity	TAS		12456957
GO:0042802	identical protein binding	IPI		2575216
GO:0048184	follistatin binding	IPI		16198295
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	NAS	neurite (GO term level: 5)	10320815
GO:0000082	G1/S transition of mitotic cell cycle	IDA		9884026
GO:0001501	skeletal system development	TAS		10865214
GO:0001541	ovarian follicle development	NAS		9166111
GO:0007267	cell-cell signaling	TAS		12456957
GO:0006917	induction of apoptosis	IDA		8267637
GO:0007166	cell surface receptor linked signal transduction	TAS		12456957
GO:0007050	cell cycle arrest	IDA		9884026
GO:0009605	response to external stimulus	TAS		10320815
GO:0006952	defense response	TAS		12456957
GO:0042326	negative regulation of phosphorylation	TAS		12456957
GO:0030154	cell differentiation	TAS		12456957
GO:0042541	hemoglobin biosynthetic process	IDA		1310063
GO:0032925	regulation of activin receptor signaling pathway	IDA		9884026
GO:0030308	negative regulation of cell growth	IDA		9884026
GO:0040007	growth	IEA		-
GO:0045648	positive regulation of erythrocyte differentiation	IDA		9032295
GO:0045650	negative regulation of macrophage differentiation	TAS		12456957
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA		12702211
GO:0046881	positive regulation of follicle-stimulating hormone secretion	TAS		12456957
GO:0046882	negative regulation of follicle-stimulating hormone secretion	NAS		3267209
GO:0045077	negative regulation of interferon-gamma biosynthetic process	TAS		12456957
GO:0045786	negative regulation of cell cycle	IDA		9884026
GO:0045578	negative regulation of B cell differentiation	TAS		12456957
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	IDA		12213882
GO:0043509	activin A complex	IDA		7890768
GO:0043512	inhibin A complex	IDA		7890768

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACVR1	ACTRI \| ACVR1A \| ACVRLK2 \| ALK2 \| FOP \| SKR1 \| TSRI	activin A receptor, type I	-	HPRD	11266516
ACVR1B	ACTRIB \| ACVRLK4 \| ALK4 \| SKR2	activin A receptor, type IB	Affinity Capture-Western	BioGRID	9202237
ACVR1B	ACTRIB \| ACVRLK4 \| ALK4 \| SKR2	activin A receptor, type IB	-	HPRD	8397373
ACVR2A	ACTRII \| ACVR2	activin A receptor, type IIA	Affinity Capture-Western	BioGRID	9202237 \|10746731
ACVR2A	ACTRII \| ACVR2	activin A receptor, type IIA	-	HPRD	11266516
ACVR2B	ACTRIIB \| ActR-IIB \| MGC116908	activin A receptor, type IIB	-	HPRD,BioGRID	9202237
CHRDL2	BNF1 \| CHL2 \| DKFZp586N2124 \| FKSG37	chordin-like 2	-	HPRD,BioGRID	15094188
ENG	CD105 \| END \| FLJ41744 \| HHT1 \| ORW \| ORW1	endoglin	-	HPRD	9872992
FSTL3	FLRG \| FSRP	follistatin-like 3 (secreted glycoprotein)	-	HPRD,BioGRID	11459787
IGFBP7	FSTL2 \| IGFBP-7 \| IGFBP-7v \| IGFBPRP1 \| MAC25 \| PSF	insulin-like growth factor binding protein 7	-	HPRD,BioGRID	10859029
INHA	-	inhibin, alpha	-	HPRD	11134153
INHBA	EDF \| FRP	inhibin, beta A	-	HPRD	11134153
INHBA	EDF \| FRP	inhibin, beta A	Activin A interacts with itself to form a homodimer.	BIND	8015550
INHBB	MGC157939	inhibin, beta B	-	HPRD	11134153
INHBC	IHBC	inhibin, beta C	-	HPRD	11134153
TGFBR3	BGCAN \| betaglycan	transforming growth factor, beta receptor III	-	HPRD	10746731

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	267	161	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
PID ALK1 PATHWAY	26	21	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	200	136	All SZGR 2.0 genes in this pathway
REACTOME GLYCOPROTEIN HORMONES	12	8	All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE HORMONE BIOSYNTHESIS	14	10	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP	255	177	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP	73	50	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP	69	38	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE DN	66	44	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN	62	35	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP	175	120	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP	136	80	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN	41	29	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP	204	140	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP	141	75	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN	209	122	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP	57	33	All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN	95	57	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP	66	47	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA REVERSIBLY DN	29	21	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5	147	89	All SZGR 2.0 genes in this pathway
WANG METHYLATED IN BREAST CANCER	35	25	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 DN	51	42	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN	382	224	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN	57	45	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN	45	33	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION UP	69	55	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 60 MCF10A	39	24	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 60 MCF10A	57	42	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP	223	140	All SZGR 2.0 genes in this pathway
DING LUNG CANCER MUTATED SIGNIFICANTLY	26	22	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP	118	66	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP	71	51	All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP	83	56	All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN	85	56	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP	207	145	All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP	114	84	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION 2	53	34	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
NIELSEN LIPOSARCOMA DN	19	8	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN	245	144	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP	222	139	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP	253	147	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP	56	36	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP	260	174	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP	111	70	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS	80	56	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A	67	52	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3	128	68	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP	87	50	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN	222	147	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
WIEDERSCHAIN TARGETS OF BMI1 AND PCGF2	57	39	All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP	100	70	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP	199	143	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP	221	120	All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP	63	43	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway
ANASTASSIOU CANCER MESENCHYMAL TRANSITION SIGNATURE	64	40	All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP	110	68	All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP	86	54	All SZGR 2.0 genes in this pathway
ZWANG CLASS 2 TRANSIENTLY INDUCED BY EGF	51	29	All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS	344	197	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-135	412	418	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	412	418	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-205	172	179	1A,m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: INHBA