Gene Page: SMAD1

Summary
GeneID  4086
Symbol  SMAD1
Synonyms  BSP1|JV4-1|JV41|MADH1|MADR1
Description  SMAD family member 1
See related  HGNC:6767|MIM:601595|Ensembl:ENSG00000170365|HPRD:03356|
Locus tag  -
Gene type  protein-coding
Map location  4q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SLC25A180.500.59
P2RY140.500.56
AC011427.10.500.57
GLUL0.490.58
NDRG20.480.58
ALDOC0.480.56
ADHFE10.480.54
GPER0.480.58
SNTA10.480.57
CLDN100.480.58
Top 10 negatively co-expressed genes
SAAL1-0.46-0.57
CNOT10-0.46-0.54
TRA2A-0.46-0.51
PGBD1-0.46-0.51
USPL1-0.46-0.54
ZNF589-0.46-0.50
RAE1-0.46-0.51
ZNF329-0.46-0.49
ZNF182-0.46-0.50
ZNF509-0.45-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityNAS8653785 |10708949 
GO:0003700transcription factor activityIEA-
GO:0003702RNA polymerase II transcription factor activityIEA-
GO:0005515protein bindingIPI15781469 
GO:0016563transcription activator activityNAS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030902hindbrain developmentIEABrain (GO term level: 8)-
GO:0030901midbrain developmentIEABrain (GO term level: 8)-
GO:0000165MAPKKK cascadeIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007165signal transductionNAS9759503 
GO:0007179transforming growth factor beta receptor signaling pathwayNAS8663601 
GO:0008285negative regulation of cell proliferationIEA-
GO:0009880embryonic pattern specificationISS-
GO:0007276gamete generationIEA-
GO:0042592homeostatic processIEA-
GO:0030509BMP signaling pathwayEXP15621726 
GO:0030509BMP signaling pathwayISS-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9436979 |17356069 
GO:0005622intracellularIEA-
GO:0005622intracellularNAS10647776 
GO:0005634nucleusNAS9759503 
GO:0005654nucleoplasmEXP11121043 
GO:0005667transcription factor complexIEA-
GO:0005737cytoplasmIEA-
GO:0016021integral to membraneNAS8663601 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR1ACTRI | ACVR1A | ACVRLK2 | ALK2 | FOP | SKR1 | TSRIactivin A receptor, type I-HPRD9748228 |10583507 
|10652350 
Affinity Capture-WesternBioGRID9748228 |10652350 
BMP7OP-1bone morphogenetic protein 7Phenotypic SuppressionBioGRID11438941 
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IA-HPRD11438941 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-WesternBioGRID10673036 |11239394 
DVL1DVL | MGC54245dishevelled, dsh homolog 1 (Drosophila)Reconstituted ComplexBioGRID12650946 
ECSITSITPECECSIT homolog (Drosophila)-HPRD14633973 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID10673036 
ERBB2IPERBIN | LAP2erbb2 interacting protein-HPRD,BioGRID12650946 
FOXG1BF1 | BF2 | FHKL3 | FKH2 | FKHL1 | FKHL2 | FKHL3 | FKHL4 | FOXG1A | FOXG1B | FOXG1C | HBF-1 | HBF-2 | HBF-3 | HBF-G2 | HBF2 | HFK1 | HFK2 | HFK3 | KHL2 | QINforkhead box G1-HPRD,BioGRID11387330 
GDF6BMP13 | CDMP2 | KFS | KFSL | MGC158100 | MGC158101 | SGM1growth differentiation factor 6-HPRD15246821 
GLI3ACLS | GCPS | PAP-A | PAPA | PAPA1 | PAPB | PHS | PPDIVGLI-Kruppel family member GLI3-HPRD9843199 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2-HPRD,BioGRID12874272 
HOXC8HOX3 | HOX3Ahomeobox C8-HPRD,BioGRID10224145 |11139569 
LEF1DKFZp586H0919 | TCF1ALPHAlymphoid enhancer-binding factor 1-HPRD,BioGRID10890911 
LEMD3MAN1LEM domain containing 3LEMD3 interacts with Smad1. This interaction was modelled on a demonstrated interaction between human LEMD3 and mouse Smad1.BIND15489854 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD,BioGRID11118211 
NEUROG1AKA | Math4C | NEUROD3 | bHLHa6 | ngn1neurogenin 1-HPRD,BioGRID11239394 
OAZ3AZ3 | OAZ-t | TISP15ornithine decarboxylase antizyme 3Two-hybridBioGRID11438941 
PARD3BALS2CR19 | MGC16131 | PAR3B | PAR3L | PAR3LC | PAR3beta | Par3Lbpar-3 partitioning defective 3 homolog B (C. elegans)Reconstituted ComplexBioGRID12650946 
PSMB4HN3 | HsN3 | PROS26proteasome (prosome, macropain) subunit, beta type, 4-HPRD,BioGRID12097147 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene familySMAD1 interacts with RAN. This interaction was modeled on a demonstrated interaction between human SMAD1 and mouse RAN.BIND15761153 
RPS27ACEP80 | HUBCEP80 | UBA80 | UBCEP1 | UBCEP80ribosomal protein S27aTwo-hybridBioGRID11438941 
RUNX1AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aBrunt-related transcription factor 1Affinity Capture-WesternBioGRID10531362 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2Affinity Capture-WesternBioGRID10531362 |10962029 
RUNX3AML2 | CBFA3 | FLJ34510 | MGC16070 | PEBP2aCrunt-related transcription factor 3Affinity Capture-WesternBioGRID10531362 
SKISKVv-ski sarcoma viral oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex		BioGRID12874272 
SKILSNO | SnoA | SnoNSKI-like oncogeneSmad1 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad1.BIND12426322 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD10400705 |11700304 
Affinity Capture-Western
Co-fractionation		BioGRID10531362 |11700304 
|12874272 
Smad4 interacts with Smad1.BIND15761153 
SMAD6HsT17432 | MADH6 | MADH7SMAD family member 6-HPRD11483516 
SMURF2DKFZp686F0270 | MGC138150SMAD specific E3 ubiquitin protein ligase 2SMAD1 interacts with SMURF2.BIND15761153 
-HPRD,BioGRID11016919 
SNIP1FLJ12553 | RP3-423B22.3 | dJ423B22.2Smad nuclear interacting protein 1-HPRD,BioGRID10887155 
SNX6MGC3157 | MSTP010 | TFAF2sorting nexin 6-HPRD11279102 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Affinity Capture-WesternBioGRID10205054 
STUB1CHIP | HSPABP2 | NY-CO-7 | SDCCAG7 | UBOX1STIP1 homology and U-box containing protein 1Smad1 interacts with CHIP. This interaction was modeled on a demonstrated interaction between Smad1 and CHIP, both from an unspecified species.BIND15708501 
TGIF1HPE4 | MGC39747 | MGC5066 | TGIFTGFB-induced factor homeobox 1Affinity Capture-WesternBioGRID10199400 
TOB1APRO6 | MGC104792 | MGC34446 | PIG49 | TOB | TROB | TROB1transducer of ERBB2, 1-HPRD,BioGRID11163184 
UBA52CEP52 | HUBCEP52 | MGC126879 | MGC126881 | MGC57125 | RPL40ubiquitin A-52 residue ribosomal protein fusion product 1Two-hybridBioGRID11438941 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD12519765 
ZEB1AREB6 | BZP | DELTA-EF1 | MGC133261 | NIL-2-A | NIL-2A | NIL2A | TCF8 | ZEB | ZFHEP | ZFHX1Azinc finger E-box binding homeobox 1Affinity Capture-WesternBioGRID12743038 
ZEB2KIAA0569 | SIP-1 | SIP1 | SMADIP1 | ZFHX1Bzinc finger E-box binding homeobox 2-HPRD10400677 
ZNF423Ebfaz | KIAA0760 | MGC138520 | MGC138522 | OAZ | Roaz | ZFP423 | Zfp104zinc finger protein 423-HPRD,BioGRID10660046 
ZNF521DKFZp564D0764 | EHZF | Evi3 | MGC142182 | MGC142208zinc finger protein 521-HPRD14630787 
ZNF8HF.18 | Zfp128zinc finger protein 8-HPRD12370310 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_CTCF_PATHWAY 2318All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
PID_ALK1_PATHWAY 2621All SZGR genes in this pathway
PID_ALK2_PATHWAY 119All SZGR genes in this pathway
REACTOME_SIGNALING_BY_BMP 2315All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
TURJANSKI_MAPK1_AND_MAPK2_TARGETS 1210All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
MORI_PLASMA_CELL_DN 3320All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_2WK 4836All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
ZHANG_ANTIVIRAL_RESPONSE_TO_RIBAVIRIN_DN 5132All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
MATZUK_EMBRYONIC_GERM_CELL 1916All SZGR genes in this pathway
BOQUEST_STEM_CELL_DN 216143All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_UP 8054All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_LB_DN 4423All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KANG_AR_TARGETS_DN 1912All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-182100810151A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-20550561Ahsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2646531A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-30-5p2062121Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3702552611Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-96100910151Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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