SZGR2

Summary ?

GeneID	4133
Symbol	MAP2
Synonyms	MAP2A\|MAP2B\|MAP2C
Description	microtubule associated protein 2
Reference	MIM:157130\|HGNC:HGNC:6839\|Ensembl:ENSG00000078018\|HPRD:01140\|Vega:OTTHUMG00000132962
Gene type	protein-coding
Map location	2q34-q35
Pascal p-value	0.032
Fetal beta	0.579
eGene	Myers' cis & trans
Support	STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_mGluR5 G2Cdb.humanNRC CompositeSet Darnell FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00916
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01016
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.2138

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs235427	chr8	133815575	MAP2	4133	0.17	trans
rs7894597	chr10	9384581	MAP2	4133	0.03	trans
rs1324669	chr13	107872446	MAP2	4133	0.16	trans
rs17188417	chr14	90517901	MAP2	4133	0.2	trans
rs6098023	chr20	53113740	MAP2	4133	0.17	trans
rs17145698	chrX	40218345	MAP2	4133	0.03	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003674	molecular_function	ND		-
GO:0005516	calmodulin binding	IEA		-
GO:0005198	structural molecule activity	NAS		9588626
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007026	negative regulation of microtubule depolymerization	IEA		-
GO:0008150	biological_process	ND		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005856	cytoskeleton	IEA		-
GO:0005874	microtubule	IEA		-
GO:0005875	microtubule associated complex	NAS		7854050
GO:0005875	microtubule associated complex	TAS		9588626
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APOE	AD2 \| LPG \| MGC1571 \| apoprotein	apolipoprotein E	-	HPRD	8624078
CPEB1	CEBP \| CPE-BP1 \| CPEB \| FLJ13203 \| MGC34136 \| MGC60106	cytoplasmic polyadenylation element binding protein 1	-	HPRD	12629046
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	Affinity Capture-Western	BioGRID	11546790
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	10781592 \|11546790\|11546790
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
GRIN2D	EB11 \| NMDAR2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	-	HPRD	10862698
MAP2	DKFZp686I2148 \| MAP2A \| MAP2B \| MAP2C	microtubule-associated protein 2	-	HPRD,BioGRID	10527895
MARK4	FLJ90097 \| KIAA1860 \| MARKL1 \| Nbla00650	MAP/microtubule affinity-regulating kinase 4	-	HPRD,BioGRID	14594945
MYO7A	DFNA11 \| DFNB2 \| MYOVIIA \| MYU7A \| NSRD2 \| USH1B	myosin VIIA	-	HPRD,BioGRID	11171103
NEFL	CMT1F \| CMT2E \| FLJ53642 \| NF-L \| NF68 \| NFL	neurofilament, light polypeptide	Reconstituted Complex	BioGRID	1902666
PLEC1	EBS1 \| EBSO \| HD1 \| PCN \| PLEC1b \| PLTN	plectin 1, intermediate filament binding protein 500kDa	-	HPRD,BioGRID	3027087
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	10781592
TTBK1	BDTK \| KIAA1855 \| RP3-330M21.4	tau tubulin kinase 1	-	HPRD	7556643

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA AKAPCENTROSOME PATHWAY	15	14	All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY	47	37	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN	175	82	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN	198	110	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN	329	219	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN	77	52	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN	164	111	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP	21	15	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP	101	69	All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP	81	52	All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES	37	26	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
MASSARWEH RESPONSE TO ESTRADIOL	61	47	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN	353	226	All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP	45	28	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP	111	70	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN	68	45	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN	44	34	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
HOELZEL NF1 TARGETS UP	139	93	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN	229	135	All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS SKIN UP	38	27	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP	266	142	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-129-5p	3477	3483	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	3477	3483	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-139	121	127	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-141/200a	481	487	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	481	487	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-17-5p/20/93.mr/106/519.d	658	664	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-186	82	89	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-194	3589	3595	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-194	3589	3595	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-200bc/429	264	270	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-214	2922	2929	1A,m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-23	893	899	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	893	899	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-26	822	829	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	822	829	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-30-5p	1115	1121	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-335	43	49	m8	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-338	3515	3521	m8	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-361	3572	3579	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p	265	271	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-369-3p	265	271	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	764	770	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-374	764	770	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-381	490	496	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-450	3477	3483	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-496	457	463	m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-539	788	794	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-544	167	174	1A,m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAP2