Summary ?
GeneID596
SymbolBCL2
SynonymsBcl-2|PPP1R50
DescriptionB-cell CLL/lymphoma 2
ReferenceMIM:151430|HGNC:HGNC:990|HPRD:01045|
Gene typeprotein-coding
Map location18q21.3
Pascal p-value0.025
Sherlock p-value0.276
Fetal beta1.981
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1729 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg221520501860987904BCL24.796E-4-0.2350.046DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6879593chr575253310BCL25960.05trans
rs2655880chr1260797980BCL25960.16trans
rs10784054chr1260822443BCL25960.16trans
rs2036975chr1330181116BCL25960.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZFYVE280.900.87
ZBTB7A0.880.90
CBX70.880.93
PACSIN10.880.89
SYNM0.880.84
CNTNAP10.880.82
MAP1A0.880.81
SIRPA0.870.88
IQSEC30.870.76
COBL0.860.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C9orf46-0.67-0.80
EXOSC8-0.65-0.75
DYNLT1-0.64-0.82
BCL7C-0.64-0.73
TUBB2B-0.64-0.63
TRAF4-0.64-0.72
RPS8-0.62-0.80
AC079354.7-0.62-0.68
RPS18-0.62-0.77
KIAA1949-0.62-0.51

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0002020protease bindingIDA10620603 
GO:0042803protein homodimerization activityIDA9111042 
GO:0046982protein heterodimerization activityIPI9111042 
GO:0051434BH3 domain bindingIPI9111042 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0043524negative regulation of neuron apoptosisIEAneuron (GO term level: 9)-
GO:0001836release of cytochrome c from mitochondriaNAS9027314 
GO:0008219cell deathIDA8949945 
GO:0008284positive regulation of cell proliferationIEA-
GO:0008633activation of pro-apoptotic gene productsEXP15231831 
GO:0010039response to iron ionIDA11264898 
GO:0034097response to cytokine stimulusIDA9184696 
GO:0009636response to toxinIDA16307838 
GO:0007565female pregnancyNAS11530860 
GO:0006959humoral immune responseTAS1908951 
GO:0006916anti-apoptosisIDA9027314 |10506221 |10620603 
|11684014 
GO:0009314response to radiationNAS15799693 
GO:0042100B cell proliferationIDA1373874 
GO:0031069hair follicle morphogenesisIEA-
GO:0042493response to drugIDA8949945 
GO:0043496regulation of protein homodimerization activityIDA9111042 
GO:0043497regulation of protein heterodimerization activityIDA9111042 
GO:0051607defense response to virusIDA10620603 
GO:0043473pigmentationIEA-
GO:0032848negative regulation of cellular pH reductionIDA10506221 
GO:0035094response to nicotineIDA12421819 
GO:0046902regulation of mitochondrial membrane permeabilityISS9843949 
GO:0045069regulation of viral genome replicationIEA-
GO:0051881regulation of mitochondrial membrane potentialISS9843949 
GO:0051902negative regulation of mitochondrial depolarizationTAS9027314 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA11530860 
GO:0005739mitochondrionIDA9027314 
GO:0005741mitochondrial outer membraneEXP10198631 |11463392 |12624108 
GO:0005741mitochondrial outer membraneIDA9027314 
GO:0005741mitochondrial outer membraneTAS1453000 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0031965nuclear membraneIDA1502141 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATP2A2ATP2B | DAR | DD | DKFZp686P0211 | FLJ20293 | FLJ38063 | MGC45367 | SERCA2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2-HPRD9788433 
AVENPDCD12apoptosis, caspase activation inhibitorAffinity Capture-Western
Two-hybrid
BioGRID10949025 
BADBBC2 | BCL2L8BCL2-associated agonist of cell deathBcl-2 interacts with Bad.BIND9130713 
BADBBC2 | BCL2L8BCL2-associated agonist of cell death-HPRD,BioGRID7834748 
BADBBC2 | BCL2L8BCL2-associated agonist of cell deathBad interacts with Bcl-2.BIND15694340 
BADBBC2 | BCL2L8BCL2-associated agonist of cell deathBad interacts with Bcl-2.BIND15574335 
BAG1RAP46BCL2-associated athanogene-HPRD,BioGRID9305631 
BAG3BAG-3 | BIS | CAIR-1 | MGC104307BCL2-associated athanogene 3Bcl-2 interacts with BAG-3. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-3.BIND11527400 
BAG3BAG-3 | BIS | CAIR-1 | MGC104307BCL2-associated athanogene 3-HPRD11513873 
BAG4BAG-4 | SODDBCL2-associated athanogene 4-HPRD,BioGRID11527400 
BAG4BAG-4 | SODDBCL2-associated athanogene 4Bcl-2 interacts with BAG-4. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-4.BIND11527400 
BAK1BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887BCL2-antagonist/killer 1-HPRD,BioGRID11728179 
BAXBCL2L4BCL2-associated X protein-HPRD,BioGRID8358790 
BAXBCL2L4BCL2-associated X proteinBax interacts with Bcl-2.BIND15574335 
BAXBCL2L4BCL2-associated X protein-HPRD8358790|9111042 
BAXBCL2L4BCL2-associated X proteinBcl-2 interacts with Bax.BIND9130713 
BBC3JFY1 | PUMABCL2 binding component 3PUMA-beta interacts with Bcl-2.BIND11463392 
BBC3JFY1 | PUMABCL2 binding component 3-HPRD,BioGRID11463392 
BBC3JFY1 | PUMABCL2 binding component 3PUMA interacts with Bcl-2.BIND15574335 
BBC3JFY1 | PUMABCL2 binding component 3PUMA-alpha interacts with Bcl-2.BIND11463392 
BBC3JFY1 | PUMABCL2 binding component 3Puma interacts with Bcl-2.BIND15694340 
BCAP316C6-AG | BAP31 | CDM | DXS1357EB-cell receptor-associated protein 31-HPRD,BioGRID9334338 
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD9111042 |15302859 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD11583631 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1Affinity Capture-Western
Protein-peptide
BioGRID12137781 |14980220 
BCL2L10BCL-B | Boo | Diva | MGC129810 | MGC129811BCL2-like 10 (apoptosis facilitator)-HPRD,BioGRID11278245 
BCL2L11BAM | BIM | BIM-alpha6 | BIM-beta6 | BIM-beta7 | BOD | BimEL | BimLBCL2-like 11 (apoptosis facilitator)-HPRD,BioGRID9430630 
BCL2L11BAM | BIM | BIM-alpha6 | BIM-beta6 | BIM-beta7 | BOD | BimEL | BimLBCL2-like 11 (apoptosis facilitator)Bim interacts with Bcl-2.BIND15694340 
BCL2L14BCLGBCL2-like 14 (apoptosis facilitator)-HPRD11054413 
BCLAF1BTF | KIAA0164 | bK211L9.1BCL2-associated transcription factor 1-HPRD10330179 
BECN1ATG6 | VPS30 | beclin1beclin 1, autophagy related-HPRD,BioGRID9765397 
BFARBAR | RNF47bifunctional apoptosis regulator-HPRD10716992 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistBid interacts with Bcl-2.BIND15694340 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistProtein-peptideBioGRID15520201 |15694340 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistBid interacts with Bcl-2.BIND15574335 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonist-HPRD9727491 
BIKBIP1 | BP4 | NBKBCL2-interacting killer (apoptosis-inducing)-HPRD9525867 |12853473|12853473 
BIKBIP1 | BP4 | NBKBCL2-interacting killer (apoptosis-inducing)Bcl-2 interacts with Bik.BIND9130713 
BIKBIP1 | BP4 | NBKBCL2-interacting killer (apoptosis-inducing)Bik interacts with Bcl-2.BIND15694340 
BIKBIP1 | BP4 | NBKBCL2-interacting killer (apoptosis-inducing)-HPRD,BioGRID12853473 
BLKMGC10442B lymphoid tyrosine kinase-HPRD,BioGRID9525867 
BMFFLJ00065Bcl2 modifying factorBmf interacts with Bcl-2. This interaction was modelled on a demonstrated interaction between mouse Bmf and human Bcl-2.BIND15694340 
BMFFLJ00065Bcl2 modifying factor-HPRD,BioGRID11546872 
BNIP1NIP1 | SEC20 | TRG-8BCL2/adenovirus E1B 19kDa interacting protein 1-HPRD,BioGRID10217402 
BNIP2BNIP-2 | NIP2BCL2/adenovirus E1B 19kDa interacting protein 2-HPRD,BioGRID7954800 |12901880 
BNIP3NIP3BCL2/adenovirus E1B 19kDa interacting protein 3-HPRD,BioGRID10625696 
BNIP3LBNIP3a | NIXBCL2/adenovirus E1B 19kDa interacting protein 3-like-HPRD,BioGRID9973195|10467396 
BNIPLBNIP-S | BNIPL-1 | BNIPL-2 | BNIPL1 | BNIPL2 | PP753BCL2/adenovirus E1B 19kD interacting protein like-HPRD,BioGRID12901880 
BNIPLBNIP-S | BNIPL-1 | BNIPL-2 | BNIPL1 | BNIPL2 | PP753BCL2/adenovirus E1B 19kD interacting protein likeBNIPL-2 interacts with Bcl-2.BIND12901880 
CAPN2CANP2 | CANPL2 | CANPml | FLJ39928 | mCANPcalpain 2, (m/II) large subunitBiochemical Activity
Reconstituted Complex
BioGRID12000759 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidasePhenotypic SuppressionBioGRID11832478 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD,BioGRID11948397 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD,BioGRID11406564 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to MAffinity Capture-WesternBioGRID11326318 |11774038 
CDK2p33(CDK2)cyclin-dependent kinase 2-HPRD15619620 
CYCSCYC | HCScytochrome c, somatic-HPRD10622714 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-WesternBioGRID10198631 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2Biochemical ActivityBioGRID15225643 
FKBP8FKBP38 | FKBPr38FK506 binding protein 8, 38kDa-HPRD,BioGRID12510191 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD10490827 
HRKDP5 | HARAKIRIharakiri, BCL2 interacting protein (contains only BH3 domain)-HPRD,BioGRID9130713 |10075695 
HRKDP5 | HARAKIRIharakiri, BCL2 interacting protein (contains only BH3 domain)Hrk interacts with Bcl-2.BIND9130713 
HRKDP5 | HARAKIRIharakiri, BCL2 interacting protein (contains only BH3 domain)Hrk interacts with Bcl-2.BIND15694340 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1A-HPRD,BioGRID10354271 
IRS1HIRS-1insulin receptor substrate 1Affinity Capture-WesternBioGRID10679027 
IRS2-insulin receptor substrate 2Affinity Capture-WesternBioGRID10679027 
ITM2BABRI | BRI | BRI2 | BRICD2B | E25B | E3-16 | FBDintegral membrane protein 2B-HPRD,BioGRID12082633 
ITPR1INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16inositol 1,4,5-triphosphate receptor, type 1Affinity Capture-WesternBioGRID15613488 
KRASC-K-RAS | K-RAS2A | K-RAS2B | K-RAS4A | K-RAS4B | KI-RAS | KRAS1 | KRAS2 | NS3 | RASK2v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog-HPRD10490827 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD15225643 
MAPK11P38B | P38BETA2 | PRKM11 | SAPK2 | SAPK2B | p38-2 | p38Betamitogen-activated protein kinase 11-HPRD11495898 
MOAP1MAP-1 | PNMA4modulator of apoptosis 1-HPRD,BioGRID11060313 
MOAP1MAP-1 | PNMA4modulator of apoptosis 1MAP-1 interacts with Bcl-2.BIND11060313 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-Western
Co-localization
BioGRID15210690 
NR4A1GFRP1 | HMR | MGC9485 | N10 | NAK-1 | NGFIB | NP10 | NUR77 | TR3nuclear receptor subfamily 4, group A, member 1-HPRD,BioGRID14980220 
NRASALPS4 | N-ras | NRAS1neuroblastoma RAS viral (v-ras) oncogene homolog-HPRD10490827 
P53AIP1-p53-regulated apoptosis-inducing protein 1-HPRD,BioGRID12019168 
PARP1ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1poly (ADP-ribose) polymerase 1-HPRD,BioGRID11790116 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1-HPRD11988841 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1Affinity Capture-WesternBioGRID11326318 
PKMYT1DKFZp547K1610 | FLJ20093 | MYT1protein kinase, membrane associated tyrosine/threonine 1-HPRD11326318 
PMAIP1APR | NOXAphorbol-12-myristate-13-acetate-induced protein 1-HPRD,BioGRID10807576 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoform-HPRD11390485 
PPP2CAPP2Ac | PP2CA | RP-Cprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform-HPRD,BioGRID9852076 
PPP2R4MGC2184 | PP2A | PR53 | PTPAprotein phosphatase 2A activator, regulatory subunit 4Biochemical ActivityBioGRID15225643 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoform-HPRD,BioGRID11929874 
PPP3CACALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2Bprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform-HPRD,BioGRID7593193 |9109491 
PSEN1AD3 | FAD | PS1 | S182presenilin 1-HPRD,BioGRID10521466 
RAD9ARAD9RAD9 homolog A (S. pombe)-HPRD,BioGRID10620799 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID8910675 |8929532 
RHEBMGC111559 | RHEB2Ras homolog enriched in brainBcl-2 interacts with Rheb.BIND9130713 
RRAS-related RAS viral (r-ras) oncogene homolog-HPRD,BioGRID8232588 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4RTN-XS interacts with Bcl-2.BIND11126360 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4-HPRD,BioGRID11126360 
SERPINB8CAP2 | PI8serpin peptidase inhibitor, clade B (ovalbumin), member 8Affinity Capture-WesternBioGRID15231068 
SF1D11S636 | ZFM1 | ZNF162splicing factor 1-HPRD,BioGRID8668206 
SMN1BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541survival of motor neuron 1, telomeric-HPRD,BioGRID9389483 
SOD1ALS | ALS1 | IPOA | SOD | homodimersuperoxide dismutase 1, soluble-HPRD,BioGRID15233914 
SPNS1FLJ38358 | HSpin1 | LAT | PP2030 | SPIN1 | SPINL | nrsspinster homolog 1 (Drosophila)-HPRD,BioGRID12815463 
TMBIM6BAXI1 | BI-1 | TEGTtransmembrane BAX inhibitor motif containing 6-HPRD,BioGRID9660918 
TOMM20KIAA0016 | MAS20 | MGC117367 | MOM19 | TOM20translocase of outer mitochondrial membrane 20 homolog (yeast)-HPRD,BioGRID9119086 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD12667443 
TP53BP253BP2 | ASPP2 | BBP | PPP1R13A | p53BP2tumor protein p53 binding protein, 2-HPRD,BioGRID8668206 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 6247All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 8975All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 8467All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY 2215All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY 2216All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY 3826All SZGR 2.0 genes in this pathway
BIOCARTA IL7 PATHWAY 1714All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 4638All SZGR 2.0 genes in this pathway
BIOCARTA P53 PATHWAY 1613All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY 2623All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY 2115All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA TEL PATHWAY 1815All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES 2723All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY 3732All SZGR 2.0 genes in this pathway
SA FAS SIGNALING 95All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 4638All SZGR 2.0 genes in this pathway
SA PROGRAMMED CELL DEATH 129All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 5447All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 5543All SZGR 2.0 genes in this pathway
PID IL2 PI3K PATHWAY 3427All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 4837All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
PID RXR VDR PATHWAY 2624All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 5943All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 8461All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY 3526All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
PID EPO PATHWAY 3429All SZGR 2.0 genes in this pathway
PID IL2 STAT5 PATHWAY 3023All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 6352All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF BH3 ONLY PROTEINS 1712All SZGR 2.0 genes in this pathway
REACTOME INFLAMMASOMES 1712All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 4633All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS 3021All SZGR 2.0 genes in this pathway
WINTER HYPOXIA DN 5230All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320184All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 11272All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN 11879All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM DN 4226All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP 2920All SZGR 2.0 genes in this pathway
MARKS HDAC TARGETS DN 1511All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT1 TARGETS 109All SZGR 2.0 genes in this pathway
BAKER HEMATOPOIESIS STAT3 TARGETS 1612All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT5 TARGETS 77All SZGR 2.0 genes in this pathway
GALLUZZI PERMEABILIZE MITOCHONDRIA 4331All SZGR 2.0 genes in this pathway
DUTTA APOPTOSIS VIA NFKB 3325All SZGR 2.0 genes in this pathway
GALLUZZI PREVENT MITOCHONDIAL PERMEABILIZATION 2216All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 13493All SZGR 2.0 genes in this pathway
HONRADO BREAST CANCER BRCA1 VS BRCA2 1812All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS DN 9751All SZGR 2.0 genes in this pathway
SHANK TAL1 TARGETS DN 106All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
SCHLESINGER METHYLATED DE NOVO IN CANCER 8864All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP 4333All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP 8654All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A 10063All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS 6246All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 3 2823All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 7652All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 6447All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171102All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC DN 5935All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS 6648All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
FERRANDO LYL1 NEIGHBORS 1512All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE UP 7958All SZGR 2.0 genes in this pathway
NUMATA CSF3 SIGNALING VIA STAT3 2217All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP 10176All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO METHOTREXATE DN 2719All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244151All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 9164All SZGR 2.0 genes in this pathway
ZHENG RESPONSE TO ARSENITE UP 1814All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 12893All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CAMPTOTHECIN DN 4631All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P2 7955All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN T LYMPHOCYTE DN 3729All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
CLAUS PGR POSITIVE MENINGIOMA DN 1210All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217122All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 11580All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS 1916All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS UP 4831All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
MATZUK EMBRYONIC GERM CELL 1916All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 7255All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 9175All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS UP 4025All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 7450All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP 16799All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 7561All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE UP 4334All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE 8166All SZGR 2.0 genes in this pathway
ZHAN LATE DIFFERENTIATION GENES UP 3324All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL UP 7349All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 10575All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN 4223All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2 8650All SZGR 2.0 genes in this pathway
NIELSEN MALIGNAT FIBROUS HISTIOCYTOMA DN 1811All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229149All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 11687All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS 1613All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 15186All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR DN 5535All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-143181918251Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-149239824041Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/497252925361A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-15326321Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-181175217581Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1822052111Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-204/2112092161A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-20539203926m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-217207261Ahsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-217256825741Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-30-5p248724931Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-34/4492032091Ahsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-365171117171Ahsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-3847047101Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-4485864m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-493-5p37463752m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-503253025361Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-962052111Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC