Gene Page: TAF5

Summary ?
GeneID6877
SymbolTAF5
SynonymsTAF(II)100|TAF2D|TAFII-100|TAFII100
DescriptionTATA-box binding protein associated factor 5
ReferenceMIM:601787|HGNC:HGNC:11539|Ensembl:ENSG00000148835|HPRD:11876|Vega:OTTHUMG00000018985
Gene typeprotein-coding
Map location10q24-q25.2
Pascal p-value0.002
Fetal beta1.193
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
LK:YESGenome-wide Association StudyThis data set included 99 genes mapped to the 22 regions. The 24 leading SNPs were also included in CV:Ripke_2013

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7860423chr9140955546TAF568770.15trans
rs17650385chr1387104244TAF568770.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RAB100.910.92
ABCD30.900.91
RAD210.900.91
ASCC10.900.88
C5orf430.890.88
COPB10.890.88
PPP1CC0.890.92
IFIT50.890.91
ZNF2710.890.88
STAG20.890.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.66-0.76
FXYD1-0.65-0.75
AC018755.7-0.63-0.71
IFI27-0.63-0.73
AF347015.8-0.63-0.74
AF347015.33-0.63-0.72
AF347015.21-0.62-0.72
AF347015.31-0.62-0.71
AF347015.27-0.61-0.70
MT-CYB-0.61-0.71

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CPSF1CPSF160 | HSU37012 | P/cl.18cleavage and polyadenylation specific factor 1, 160kDain vitroBioGRID9311784 
GTF2F2BTF4 | RAP30 | TF2F2 | TFIIFgeneral transcription factor IIF, polypeptide 2, 30kDa-HPRD8758937 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Reconstituted ComplexBioGRID12660246 
SUPT3HSPT3 | SPT3Lsuppressor of Ty 3 homolog (S. cerevisiae)Affinity Capture-WesternBioGRID11406595 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa-HPRD,BioGRID9045704 
TAF11MGC:15243 | PRO2134 | TAF2I | TAFII28TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa-HPRD,BioGRID9045704 
TAF12TAF2J | TAFII20TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa-HPRD,BioGRID9045704 
TAF15Npl3 | RBP56 | TAF2N | TAFII68 | hTAFII68TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaAffinity Capture-Western
Reconstituted Complex		BioGRID9488465 
TAF4FLJ41943 | TAF2C | TAF2C1 | TAF4A | TAFII130 | TAFII135TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDaAffinity Capture-WesternBioGRID11406595 
TAF6DKFZp781E21155 | MGC:8964 | TAF2E | TAFII70 | TAFII80 | TAFII85TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa-HPRD,BioGRID9045704 
TAF7TAF2F | TAFII55TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDaAffinity Capture-WesternBioGRID9045704 
TAF9AD-004 | AK6 | CGI-137 | CINAP | CIP | MGC1603 | MGC3647 | MGC5067 | MGC:1603 | MGC:3647 | MGC:5067 | TAF2G | TAFII31 | TAFII32 | TAFIID32TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa-HPRD,BioGRID9045704 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID9045704 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG BASAL TRANSCRIPTION FACTORS 3624All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION 10554All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 4121All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 6132All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 12569All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 10461All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 13976All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205145All SZGR 2.0 genes in this pathway
NAGY TFTC COMPONENTS HUMAN 1911All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330217All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE 10568All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 5035All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163115All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE ALL UP 1915All SZGR 2.0 genes in this pathway