Gene Page: NRP2

Summary
GeneID  8828
Symbol  NRP2
Synonyms  MGC126574|NP2|NPN2|PRO2714|VEGF165R2
Description  neuropilin 2
See related  HGNC:8005|MIM:602070|Ensembl:ENSG00000118257|HPRD:03643|
Locus tag  -
Gene type  protein-coding
Map location  2q33.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
UBA10.950.95
USP190.940.95
DHX300.940.94
ZFYVE10.940.94
XPO60.930.94
TNPO20.930.95
EFTUD20.930.95
AMBRA10.930.95
RIC8A0.930.95
FAM40A0.930.96
Top 10 negatively co-expressed genes
AF347015.31-0.82-0.87
MT-CO2-0.81-0.87
AF347015.27-0.81-0.87
AF347015.8-0.80-0.87
AF347015.21-0.79-0.92
AF347015.33-0.79-0.84
MT-CYB-0.78-0.84
AF347015.15-0.76-0.83
AF347015.2-0.75-0.83
FXYD1-0.75-0.81
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005021vascular endothelial growth factor receptor activityNAS11112349 
GO:0005021vascular endothelial growth factor receptor activityTAS9331348 
GO:0004872receptor activityTAS9288754 
GO:0017154semaphorin receptor activityIEA-
GO:0017154semaphorin receptor activityNAS11112349 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceTASaxon (GO term level: 13)9288754 
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0001755neural crest cell migrationIEA-
GO:0001525angiogenesisNAS11112349 
GO:0007155cell adhesionIEA-
GO:0007155cell adhesionNAS11112349 
GO:0007507heart developmentIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0050919negative chemotaxisIEA-
GO:0045454cell redox homeostasisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS9288754 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS11112349 
GO:0005886plasma membraneEXP11278319 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PGFD12S1900 | PGFL | PLGF | PlGF-2 | SHGC-10760placental growth factor-HPRD10748121 
NP-2(a22) interacts with PlGF-2.BIND10748121 
NP-2(a17) interacts with PlGF-2.BIND10748121 
SEMA3BFLJ34863 | LUCA-1 | SEMA5 | SEMAA | SemA | semaVsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B-HPRD10196546 
SEMA3FSEMA-IV | SEMA4 | SEMAKsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3FSema3F interacts with Npn-2. This interaction was modeled on a demonstrated interaction between human Sema3F and rat Npn-2.BIND15550623 
-HPRD9883722 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor A-HPRD10748121 
NP-2 interacts with VEGF145.BIND10748121 
NP-2 interacts with VEGF165.BIND10748121 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_VEGF_VEGFR_PATHWAY 106All SZGR genes in this pathway
PID_VEGFR1_PATHWAY 2623All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS 106All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN 14383All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_HIGH_RECURRENCE 4931All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
NIELSEN_LIPOSARCOMA_DN 198All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_DN 7849All SZGR genes in this pathway
LIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK 1812All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA2_UP 8750All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_2_UP 5431All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_3_UP 17097All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_4_UP 11264All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_5_UP 128All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_7_UP 11868All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_UP 11573All SZGR genes in this pathway
KRIEG_HYPOXIA_VIA_KDM3A 5334All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/20631371Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-1027742780m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-124/50614291435m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-128296729731Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-141/200a19211927m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-14619952001m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-15/16/195/424/49717981804m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-18387931Ahsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-200bc/42926952701m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2729672973m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-32827682774m8hsa-miR-328brainCUGGCCCUCUCUGCCCUUCCGU
miR-3316456521A,m8hsa-miR-331brainGCCCCUGGGCCUAUCCUAGAA
miR-381302330291Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-496298129871Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-5046666721Ahsa-miR-504AGACCCUGGUCUGCACUCUAU
miR-543188018861Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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