SZGR2

Summary ?

GeneID	8894
Symbol	EIF2S2
Synonyms	EIF2\|EIF2B\|EIF2beta\|PPP1R67\|eIF-2-beta
Description	eukaryotic translation initiation factor 2 subunit beta
Reference	MIM:603908\|HGNC:HGNC:3266\|Ensembl:ENSG00000125977\|HPRD:04882\|Vega:OTTHUMG00000032287
Gene type	protein-coding
Map location	20q11.2
Pascal p-value	0.003
Sherlock p-value	0.717
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0143

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
KLHL17	0.95	0.89
AC145098.2	0.95	0.91
GIGYF1	0.93	0.92
CCDC142	0.93	0.92
QRICH2	0.93	0.92
TRPV1	0.92	0.90
ANO8	0.92	0.93
KIAA0913	0.92	0.93
ADAMTS10	0.92	0.92
MICAL1	0.92	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.65	-0.78
C5orf53	-0.65	-0.71
AF347015.27	-0.63	-0.75
ACOT13	-0.63	-0.69
B2M	-0.63	-0.71
MT-CO2	-0.61	-0.75
MT-CYB	-0.60	-0.73
S100B	-0.60	-0.69
AF347015.33	-0.60	-0.71
COPZ2	-0.59	-0.67

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003723	RNA binding	TAS		3044606
GO:0003743	translation initiation factor activity	IDA		16289705
GO:0003743	translation initiation factor activity	IEA		-
GO:0005515	protein binding	IPI		16288713
GO:0008270	zinc ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006413	translational initiation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		1104615 \|12588972
GO:0005850	eukaryotic translation initiation factor 2 complex	TAS		3044606

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APLP1	APLP	amyloid beta (A4) precursor-like protein 1	Two-hybrid	BioGRID	16169070
CCDC90B	MDS011 \| MDS025 \| MGC104239	coiled-coil domain containing 90B	Two-hybrid	BioGRID	16169070
CRMP1	DPYSL1 \| DRP-1 \| DRP1	collapsin response mediator protein 1	Two-hybrid	BioGRID	16169070
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	EIF2beta interacts with CK2alpha.	BIND	12901717
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	EIF2beta interacts with CK2beta.	BIND	12901717
EIF2B1	EIF-2B \| EIF-2Balpha \| EIF2B \| EIF2BA \| MGC117409 \| MGC125868 \| MGC125869	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	-	HPRD	9446619
EIF2B4	DKFZp586J0119 \| EIF-2B \| EIF2B \| EIF2Bdelta	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	-	HPRD	9446619
EIF2B5	CACH \| CLE \| EIF-2B \| EIF2Bepsilon \| LVWM	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	-	HPRD	9446619
EIF5	EIF-5A	eukaryotic translation initiation factor 5	-	HPRD,BioGRID	9395514 \|10805737 \|11092890
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	-	HPRD	11959995
PLEKHM1	AP162 \| B2 \| KIAA0356 \| OPTB6	pleckstrin homology domain containing, family M (with RUN domain) member 1	Two-hybrid	BioGRID	16169070
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	-	HPRD,BioGRID	9442054
TLE1	ESG \| ESG1 \| GRG1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	Two-hybrid	BioGRID	16169070
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	16169070
UNC119	HRG4	unc-119 homolog (C. elegans)	Two-hybrid	BioGRID	16169070
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA RNA PATHWAY	10	9	All SZGR 2.0 genes in this pathway
BIOCARTA EIF PATHWAY	16	9	All SZGR 2.0 genes in this pathway
BIOCARTA EIF2 PATHWAY	11	8	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1MTOR PATHWAY	20	14	All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY	29	18	All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION	222	75	All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	74	24	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	84	30	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	176	51	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER UP	23	9	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE	217	143	All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP	201	127	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
TONG INTERACT WITH PTTG1	57	32	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP	121	71	All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP	77	60	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP	176	115	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP	126	84	All SZGR 2.0 genes in this pathway
RHODES UNDIFFERENTIATED CANCER	69	44	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL	42	33	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
POS RESPONSE TO HISTAMINE DN	11	9	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA	51	35	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP	245	159	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE	81	66	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP	74	45	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	1179	1186	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1179	1186	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-186	290	296	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-27	1180	1186	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1180	1186	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-29	645	651	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-33	257	263	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
miR-33	257	263	1A	hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-335	450	456	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-362	1398	1404	m8	hsa-miR-362	AAUCCUUGGAACCUAGGUGUGAGU
miR-369-3p	277	283	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	277	284	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EIF2S2