Gene Page: TIMELESS

Summary
GeneID  8914
Symbol  TIMELESS
Synonyms  FLJ12640|FLJ20714|TIM|TIM1|hTIM
Description  timeless homolog (Drosophila)
See related  HGNC:11813|MIM:603887|Ensembl:ENSG00000111602|HPRD:04864|
Locus tag  -
Gene type  protein-coding
Map location  12q12-q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PON20.550.53
C10orf540.540.59
ACOX20.530.57
B2M0.530.57
SRGN0.520.61
GIMAP20.520.52
TMBIM10.520.60
NMI0.520.50
CXCL160.520.56
BBOX10.520.54
Top 10 negatively co-expressed genes
RTF1-0.46-0.49
DPF1-0.46-0.51
BOP1-0.46-0.50
CHD3-0.46-0.51
GTF2F1-0.46-0.49
SAFB-0.46-0.48
AC011498.3-0.45-0.49
ZNF643-0.45-0.49
NOVA2-0.45-0.49
NCL-0.45-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingISS-
GO:0046982protein heterodimerization activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002009morphogenesis of an epitheliumISS-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007049cell cycleIEA-
GO:0007067mitosisIEA-
GO:0009582detection of abiotic stimulusTAS9856466 
GO:0007623circadian rhythmISS-
GO:0006974response to DNA damage stimulusIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0016481negative regulation of transcriptionIDA9856465 
GO:0033261regulation of S phaseIMP17102137 
GO:0042127regulation of cell proliferationIMP17102137 
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000790nuclear chromatinIDA17102137 
GO:0005634nucleusIC9856465 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATRIPDKFZp762J2115 | FLJ12343 | MGC20625 | MGC21482 | MGC26740ATR interacting proteinAffinity Capture-WesternBioGRID15798197 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)Affinity Capture-WesternBioGRID15798197 
CRY1PHLL1cryptochrome 1 (photolyase-like)-HPRD10428031 
CRY2FLJ10332 | HCRY2 | KIAA0658 | PHLL2cryptochrome 2 (photolyase-like)Affinity Capture-WesternBioGRID15798197 
PER1MGC88021 | PER | RIGUI | hPERperiod homolog 1 (Drosophila)-HPRD,BioGRID9856465 
PER2FASPS | KIAA0347period homolog 2 (Drosophila)-HPRD,BioGRID9856465 
TIPINFLJ20516TIMELESS interacting protein-HPRD12875843 
Affinity Capture-Western
Co-purification		BioGRID17296725 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ATR_PATHWAY 3925All SZGR genes in this pathway
PID_CIRCADIAN_PATHWAY 1615All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP 201125All SZGR genes in this pathway
SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP 15184All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_DN 7351All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
NADERI_BREAST_CANCER_PROGNOSIS_UP 5026All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_CHROMOSOME_12_TRISOMY 2412All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
FRASOR_RESPONSE_TO_SERM_OR_FULVESTRANT_DN 5029All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
ZHANG_TLX_TARGETS_DN 8950All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WINNEPENNINCKX_MELANOMA_METASTASIS_UP 16286All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_DN 14888All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_6HR 8549All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR 12873All SZGR genes in this pathway


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