Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase

Found 134 literature records

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Entrez IDDescription
5925PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb.
1050may function as a tumor suppressor that is mutated during tumorigenesis. Abnormalties in C/EBPalpha function contribute to the development of malignancies in a variety of tisues.
22806"Short isoforms of Aiolos were detected at low levels in bone marrow of normal volunters, but were not overexpressed in a patient with acute T-cell leukemia. Data for unaltered Aiolos indicates tumor suppressor function."
22807Novel short isoforms of Helios are overexpressed in a patient with T-cell acute lymphoblastic leukemia and may contribute to the development of T-cell malignancies. Data for unaltered Helios indicates tumor suppressor function.
1029"The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia."
1029ATM and the ARF-p53 tumor suppressor pathway may cooperate in the pathogenesis of diffuse large B-cell lymphoma
7490Role of the WT1 tumor suppressor in normal hematopoiesis in embryo and adult cell lineages.
7157Methylation of CpG and CCWGG motifs in the promoter of TP53 could represent a novel mechanism leading to functional impairment of this tumor suppressor gene in ALL.
2120"Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor."
5655"The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19q13.3-4, is downregulated by hypermethylation in acute lymphoblastic leukemia."
5371Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.
5371Loss of the tumor suppressor PML in human cancers of multiple histologic origins.
1030The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells.
5925Data show that geminin is regulated transcriptionally by the retinoblastoma tumor suppressor (RB)/E2F pathway.
5414ARTS can function as a tumor suppressor protein in childhood acute lymphocytic leukemia.
3659"a novel tumor necrosis factor (ligand) superfamily, member 10-mediated tumor suppressor activity of interferon regulatory factor 1 and suggest a mechanistic basis for the synergistic antitumor activities of certain retinoids and interferons"
5915(RAR)beta functions as a tumor suppressor gene in various contexts where its absence is associated with tumorigenicity and its presence causes cell cycle arrest.
2131Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.
5925The Rb tumor suppressor is required for stress erythropoiesis.
3400Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia.
1029Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.
5925Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.
7157Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.
7490Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.
2272"FHIT methylation was accumulated through the disease progression of MDS and AML, and the role of the FHIT gene as a tumor suppressor seemed different in AML and MDS"
4763"NF1 tumor suppressor gene is a direct transcriptional target of RUNX1 and the t(8;21) fusion protein, suggesting that suppression of NF1 expression contributes to the molecular pathogenesis of acute myeloid leukemia ."
4221The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.
135138"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
5071"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
6688an upstream regulatory element has an essential role in orchestrating the dynamic PU.1 expression pattern required for lymphoid development and tumor suppression.
1050Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer.
1028Compensation by tumor suppressor genes during retinal development in mice and humans.
5925Compensation by tumor suppressor genes during retinal development in mice and humans.
5933Compensation by tumor suppressor genes during retinal development in mice and humans.
5934Compensation by tumor suppressor genes during retinal development in mice and humans.
6422Compensation by tumor suppressor genes during retinal development in mice and humans.
4221Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.
3394Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.
1052C/EBPdelta is a novel tumor suppressor gene in acute myeloid leukemia that is silenced by promoter methylation.
1030Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors.
6929Involvement of the TCF3 gene in 19p13 rearrangements and in identifying novel and cryptic TCF3 translocations and also acts as a tumor suppressor gene in b-cell precursor acute lymphoblastic leukemia.
5925Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.
1029p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
8013NOR-1 is a critical tumor suppressor of myeloid leukemogenesis that is downregulated in leukemic blasts from acute myeloid leukemia patients.
3164NUR77 is a critical tumor suppressor of myeloid leukemogenesis that is downregulated in leukemic blasts from acute myeloid leukemia patients.
55294"FBW7 is a novel tumor suppressor in T cell leukemia, and its loss may be a potential mechanism of drug resistance in T-ALL"
8848TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD
1029ARF tumor suppressor has a role in mouse models of acute leukemias [review]
1540Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
55294FBXW7/hCDC4 is a general tumor suppressor in human cancer.

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