Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase

Found 125 literature records

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Entrez IDDescription
3622"Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor."
324Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor.
6477Lack of somatic mutation in the coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene.
324Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells.
2131The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins.
7020Results indicate that the tumor suppressor activity of AP2alpha is mediated through a direct interaction with p53.
8406"down-regulation of drs mRNA is closely correlated with carcinomas which arise from adenomatous polyps in the course of the adenoma-carcinoma sequence, but most carcinomas arising de novo are independent of the tumor suppressor function of the drs gene"
160728"SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers."
650BMP2 acts as a tumor suppressor promoting apoptosis in mature colonic epithelial cells.
160728"Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids."
11186The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.
10210"topors functions as a negative regulator of cell growth, and possibly as a tumor suppressor"
1316Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.
5728"We found that indomethacin and NS-398 treatment significantly upregulated expression of the tumor suppressor gene, PTEN."
324Isoforms of the APC tumor suppressor and their ability to inhibit cell growth and tumorigenicity.
324Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.
634The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis.
22943"DKK-1 expression decreases in human colon tumors, suggesting that DKK-1 acts as a tumor suppressor gene in this neoplasia; the Wnt/beta-catenin pathway is downregulated by the induction of DKK-1 expression, a mechanism that is lost in colon cancer"
324Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma.
3678integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling
3688integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells by inhibiting HER-2 signaling
1029Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues.
324This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP).
347252IGFBP-RP4 may be a novel putative tumor suppressor protein.
2932Our findings demonstrate an unrecognized role of GSK3beta in tumor cell survival and proliferation other than its predicted role as a tumor suppressor.
27030Data show partial functional redundancy between MLH3 and PMS2 orthologues for mutation avoidance and show a role for Mlh3 in gastrointestinal and extragastrointestinal tumor suppression.
135138"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
5071"candidate tumor suppressor genes PARK2 and PACRG are epigenetically regulated in human leukemia, suggesting that abnormal methylation and regulation of PARK2 and PACRG may play a role in the pathogenesis and development of this hematological neoplasm"
4830These data imply that nm-23 may be tumor suppressor gene involved in neck squamous cell carcinomas but that it may not function as a tumor metastasis suppressor in high-stage laryngeal carcinoma.
324The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid.
7020data provide evidence that AP-2alpha acts as a tumor suppressor gene in colon cancer
324The APC tumor suppressor mutation was ssessed in the ability of apigenin in induce cell cycle arrest in HT29-APC cells.
9447The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.
2903NMDAR2A is commonly hypermethylated in primary human colorectal carcinoma and possesses tumor-suppressive activity.
23671data provides evidence to support the role of HPP1 as a tumor suppressor gene; activation of the STAT1 pathway likely represents the principal mediator of HPP1's tumor suppressive properties
999"in addition to the previously implicated tumor suppressor activity of E-cadherin, modified forms of this glycoprotein might also play a role in growth promotion"
1687DFNA5 is a novel tumor suppressor gene in CRC and a valuable molecular marker for human cancer
6876"acts as a tumour suppressor; expression is lost in prostate, breast and colon cancers"
23411SIRT1 suppresses intestinal tumor formation in vitro
1029Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity.
324The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus.
64682Cdh1 may function as a component in tumor suppression via proteolysis of Skp2 in colorectal tumorigenesis and may serve as a prognostic marker in colon cancer patients.
324815-PGDH is a direct downstream effector of HNF3beta and acts as a tumor suppressor in lung cancer.
57447[Expression of candidate tumor suppressor gene N-Myc downstream-regulated gene 2 in colon cancer].
407040"miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway"
864Data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling.
116135LRRC3B may be a novel methylation-sensitive tumor suppressor gene in CRC. LRRC3B methylation has significant tumor specificity and may be a biomarker of CRC.
1630the transcriptionally active TAp73alpha tumor suppressor is implicated in the apoptosis induced by netrin-1 in a p53-independent and DCC/ubiquitin-proteasome dependent manner.
7161the transcriptionally active TAp73alpha tumor suppressor is implicated in the apoptosis induced by netrin-1 in a p53-independent and DCC/ubiquitin-proteasome dependent manner.
1029These findings implicate MBD2 in transcriptional repression of the methylated p14(ARF) tumor suppressor gene and suggest that repression by MBD2 selectively affects a subset of methylated promoters.

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