SZGR2

Summary ?

GeneID	2353
Symbol	FOS
Synonyms	AP-1\|C-FOS\|p55
Description	FBJ murine osteosarcoma viral oncogene homolog
Reference	MIM:164810\|HGNC:HGNC:3796\|Ensembl:ENSG00000170345\|HPRD:01275\|Vega:OTTHUMG00000171774
Gene type	protein-coding
Map location	14q24.3
Pascal p-value	0.327
Sherlock p-value	0.666
Fetal beta	-1.196
DMG	1 (# studies)
eGene	Myers' cis & trans Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypal	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg12110634	14	75725749	FOS	3.96E-9	-0.01	2.45E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs2591089	chr14	76587799	FOS	2353	0.12	cis
rs2543359	chr14	76590472	FOS	2353	0.01	cis
rs935340	chr14	76591205	FOS	2353	0.02	cis
rs12059674	chr1	57630277	FOS	2353	5.909E-4	trans
rs17126801	chr1	65098162	FOS	2353	0.1	trans
rs7511937		0	FOS	2353	0.04	trans
rs17512695	chr1	73988565	FOS	2353	0.16	trans
rs17100274	chr1	77774412	FOS	2353	0.03	trans
rs6659821	chr1	110339827	FOS	2353	0.04	trans
rs4457633	chr1	204283819	FOS	2353	0.19	trans
rs1796829	chr1	239661818	FOS	2353	0.04	trans
rs12034521	chr1	239717679	FOS	2353	0.01	trans
snp_a-1990354		0	FOS	2353	5.02E-4	trans
rs17038084	chr2	85192280	FOS	2353	0	trans
rs7574684	chr2	100992911	FOS	2353	0.18	trans
rs17024129	chr2	100995144	FOS	2353	0.18	trans
rs7585898	chr2	100998292	FOS	2353	0.18	trans
rs1370627	chr2	101009384	FOS	2353	0.18	trans
rs6707117	chr2	136855504	FOS	2353	8.315E-7	trans
rs10189091	chr2	143471999	FOS	2353	0.03	trans
rs16838911	chr2	156087569	FOS	2353	0.04	trans
rs16839796	chr4	7188348	FOS	2353	0.03	trans
rs4631023	chr4	8101794	FOS	2353	0.13	trans
rs6827713	chr4	79936877	FOS	2353	0.11	trans
rs10079220	chr5	57453717	FOS	2353	0.1	trans
rs10040715	chr5	57594207	FOS	2353	6.951E-5	trans
rs16894149	chr5	61013724	FOS	2353	0.12	trans
snp_a-4217300		0	FOS	2353	4.727E-4	trans
rs163953	chr5	92289536	FOS	2353	0.09	trans
rs17134275	chr5	100634998	FOS	2353	0.08	trans
rs2141482	chr5	136760477	FOS	2353	0.11	trans
rs2189803	chr5	137684661	FOS	2353	1.233E-5	trans
rs12659857	chr5	168306133	FOS	2353	0.2	trans
snp_a-2055204		0	FOS	2353	0.03	trans
rs259913	chr5	169370782	FOS	2353	0.1	trans
rs11965040	chr6	18644344	FOS	2353	0.06	trans
rs10945911	chr6	164047509	FOS	2353	4.675E-4	trans
rs12540348	chr7	25802146	FOS	2353	0.16	trans
rs4719825	chr7	25813917	FOS	2353	0.01	trans
rs12701006	chr7	30147298	FOS	2353	0.13	trans
rs1419793	chr7	34697630	FOS	2353	0.14	trans
rs10245449	chr7	80935100	FOS	2353	0.08	trans
rs10487383	chr7	117671737	FOS	2353	0.02	trans
rs1457044	chr8	59257567	FOS	2353	0.14	trans
rs1733950	chr8	90062516	FOS	2353	5.245E-4	trans
rs1355060	chr8	118717710	FOS	2353	0.18	trans
rs2280828	chr8	118762435	FOS	2353	0.1	trans
rs9298651	chr9	10076275	FOS	2353	0	trans
rs16931018	chr9	10077048	FOS	2353	0	trans
rs11791891	chr9	87512411	FOS	2353	0.09	trans
rs2165893	chr9	87531423	FOS	2353	0.03	trans
rs3780642	chr9	87553144	FOS	2353	0.03	trans
rs6537944	chr9	137312827	FOS	2353	0.1	trans
rs1908351	chr10	57877117	FOS	2353	0.04	trans
rs3104871	chr10	57878502	FOS	2353	0	trans
rs2856339	chr12	11906818	FOS	2353	0.18	trans
rs8490	chr12	51453904	FOS	2353	2.568E-4	trans
rs1344796	chr12	76397104	FOS	2353	0.09	trans
rs7133714	chr12	120141546	FOS	2353	0.05	trans
rs11833075	chr12	122114592	FOS	2353	0.18	trans
rs3803214	chr13	25740255	FOS	2353	0.07	trans
rs7982110	chr13	59723428	FOS	2353	0.02	trans
rs149642	chr14	72653498	FOS	2353	0.14	trans
rs4905035	chr14	93489262	FOS	2353	0.03	trans
rs1885073	chr14	104357181	FOS	2353	0.01	trans
rs8047151	chr16	17209696	FOS	2353	0.02	trans
rs4271578	chr16	17213886	FOS	2353	0.09	trans
rs7219986	chr17	53263206	FOS	2353	0.2	trans
rs9646596	chr18	53049211	FOS	2353	0.13	trans
rs11152369	chr18	53066327	FOS	2353	0.18	trans
rs1942464	chr18	70509877	FOS	2353	0.04	trans
rs1797040	chr20	23907743	FOS	2353	0.08	trans
rs2424603		0	FOS	2353	0.08	trans
rs6102879	chr20	41138766	FOS	2353	0.04	trans
rs6026122	chr20	56769083	FOS	2353	0.04	trans
rs6015452	chr20	57782312	FOS	2353	0.19	trans
rs2834872	chr21	36634845	FOS	2353	0.04	trans
rs2834875	chr21	36656119	FOS	2353	0.02	trans
rs877910	chr21	36658376	FOS	2353	0.12	trans
rs134028	chr22	28048448	FOS	2353	0.1	trans
rs5768165	chr22	48318197	FOS	2353	0.03	trans
rs5768168	chr22	48319334	FOS	2353	0.03	trans
rs5768173	chr22	48321475	FOS	2353	0.03	trans
rs16978981	chrX	13538144	FOS	2353	0.03	trans
rs7879159	chrX	19481591	FOS	2353	0.08	trans
rs12006821	chrX	50424687	FOS	2353	0.03	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	IEA		-
GO:0003704	specific RNA polymerase II transcription factor activity	TAS		10918580
GO:0043565	sequence-specific DNA binding	IEA		-
GO:0046983	protein dimerization activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	IEA	neurite (GO term level: 5)	-
GO:0006306	DNA methylation	TAS		9888853
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS		10918580
GO:0006954	inflammatory response	TAS		9443941
GO:0034614	cellular response to reactive oxygen species	IDA		17217916
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	TAS		9443941
GO:0005667	transcription factor complex	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	-	HPRD,BioGRID	1828107
BATF	B-ATF \| BATF1 \| SFA-2	basic leucine zipper transcription factor, ATF-like	-	HPRD,BioGRID	8570175
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	-	HPRD,BioGRID	10497212
CEBPG	GPE1BP \| IG/EBP-1	CCAAT/enhancer binding protein (C/EBP), gamma	-	HPRD	7665092
COBRA1	DKFZp586B0519 \| KIAA1182 \| NELF-B \| NELFB	cofactor of BRCA1	-	HPRD,BioGRID	15530430
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	Reconstituted Complex	BioGRID	11782371
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD,BioGRID	9685505
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD,BioGRID	9685505
DDIT3	CEBPZ \| CHOP \| CHOP10 \| GADD153 \| MGC4154	DNA-damage-inducible transcript 3	-	HPRD,BioGRID	10523647
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	An unspecified isoform of EGFR binds to c-fos promoter.	BIND	15950906
ELK1	-	ELK1, member of ETS oncogene family	-	HPRD	7540136
ELK4	SAP1	ELK4, ETS-domain protein (SRF accessory protein 1)	-	HPRD	7540136
ELK4	SAP1	ELK4, ETS-domain protein (SRF accessory protein 1)	Sap-1a is interacts with the serum response element (SRE) of c-fos. This interaction was modeled on a demonstrated interaction between human Sap-1a and c-fos from an unspecified species.	BIND	9130707
ERG	erg-3 \| p55	v-ets erythroblastosis virus E26 oncogene homolog (avian)	-	HPRD	9681824
ETS1	ETS-1 \| EWSR2 \| FLJ10768	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	-	HPRD	8557686
ETS2	ETS2IT1	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	Reconstituted Complex	BioGRID	9334186
GATA4	MGC126629	GATA binding protein 4	-	HPRD	9207128
GTF2E2	FE \| TF2E2 \| TFIIE-B	general transcription factor IIE, polypeptide 2, beta 34kDa	Reconstituted Complex	BioGRID	8628277
GTF2F1	BTF4 \| RAP74 \| TF2F1 \| TFIIF	general transcription factor IIF, polypeptide 1, 74kDa	Reconstituted Complex	BioGRID	8628277
GTF2F2	BTF4 \| RAP30 \| TF2F2 \| TFIIF	general transcription factor IIF, polypeptide 2, 30kDa	-	HPRD,BioGRID	8628277
HNF1A	HNF1 \| LFB1 \| MODY3 \| TCF1	HNF1 homeobox A	-	HPRD,BioGRID	11134330
JAG1	AGS \| AHD \| AWS \| CD339 \| HJ1 \| JAGL1 \| MGC104644	jagged 1 (Alagille syndrome)	c-Fos interacts with Jagged1 promoter.	BIND	16023595
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	c-Jun interacts with c-Fos. This interaction was modelled on a demonstrated interaction between c-Jun from an unspecified species and c-Fos from an unspecified species.	BIND	10488148
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7816143 \|8380166 \|8440710 \|9160889 \|9872330 \|10488148 \|11053448
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	cFos interacts with cJun.	BIND	8816797 \|8816798
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD	1631061 \|7816143 \|9346889
JUNB	AP-1	jun B proto-oncogene	-	HPRD	1406655\|10764760
JUND	AP-1	jun D proto-oncogene	-	HPRD	12193410
KHSRP	FBP2 \| FUBP2 \| KSRP \| MGC99676	KH-type splicing regulatory protein	KSRP interacts with AREfos. This interaction was modeled on a demonstrated interaction between KSRP from human and AREfos from an unspecified species.	BIND	15175153
MAF	MGC71685 \| c-MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	-	HPRD	8108109
MAP3K7	TAK1 \| TGF1a	mitogen-activated protein kinase kinase kinase 7	-	HPRD	11397816
MITF	MI \| WS2A \| bHLHe32	microphthalmia-associated transcription factor	-	HPRD,BioGRID	9918847
NACA	HSD48 \| MGC117224 \| NACA1	nascent polypeptide-associated complex alpha subunit	Reconstituted Complex	BioGRID	9488446
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD,BioGRID	9642216
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Reconstituted Complex	BioGRID	10847592
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	-	HPRD,BioGRID	10777532
NFATC2	KIAA0611 \| NFAT1 \| NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	-	HPRD	8397339 \|12949493
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD	9468519
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	9671405
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD	8475068
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	NF-kappa-B interacts with c-Fos.	BIND	10488148
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Phenotypic Enhancement Two-hybrid	BioGRID	10488148
RPS6KA4	MSK2 \| RSK-B	ribosomal protein S6 kinase, 90kDa, polypeptide 4	-	HPRD,BioGRID	9792677
RUNX1	AML1 \| AML1-EVI-1 \| AMLCR1 \| CBFA2 \| EVI-1 \| PEBP2aB	runt-related transcription factor 1	-	HPRD,BioGRID	11641401
RUNX2	AML3 \| CBFA1 \| CCD \| CCD1 \| MGC120022 \| MGC120023 \| OSF2 \| PEA2aA \| PEBP2A1 \| PEBP2A2 \| PEBP2aA \| PEBP2aA1	runt-related transcription factor 2	-	HPRD,BioGRID	11641401
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	Reconstituted Complex Two-hybrid	BioGRID	9732876
SMARCD1	BAF60A \| CRACD1 \| Rsc6p	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	-	HPRD	11053448
SPI1	OF \| PU.1 \| SFPI1 \| SPI-1 \| SPI-A	spleen focus forming virus (SFFV) proviral integration oncogene spi1	Reconstituted Complex	BioGRID	9681824
SRF	MCM1	serum response factor (c-fos serum response element-binding transcription factor)	SRF interacts with the c-fos promoter CArG box. This interaction was modeled on a demonstrated interaction between human SRF and c-fos promoter CArG box from an unspecified species.	BIND	15610731
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	An unspecified isoform of STAT3 binds to c-fos promoter.	BIND	15950906
TAF1	BA2R \| CCG1 \| CCGS \| DYT3 \| KAT4 \| N-TAF1 \| NSCL2 \| OF \| P250 \| TAF2A \| TAFII250	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	-	HPRD,BioGRID	8065335
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	Affinity Capture-Western Reconstituted Complex	BioGRID	8065335
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	-	HPRD	7685215
TSC22D3	DIP \| DKFZp313A1123 \| DSIPI \| GILZ \| TSC-22R \| hDIP	TSC22 domain family, member 3	-	HPRD,BioGRID	11397794
USF2	FIP \| bHLHb12	upstream transcription factor 2, c-fos interacting	-	HPRD	1589769
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	Reconstituted Complex	BioGRID	10330159
XBP1	TREB5 \| XBP2	X-box binding protein 1	-	HPRD,BioGRID	1903538

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY	75	56	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
BIOCARTA BCELLSURVIVAL PATHWAY	16	10	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA RANKL PATHWAY	14	13	All SZGR 2.0 genes in this pathway
BIOCARTA CDMAC PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
BIOCARTA EPO PATHWAY	19	13	All SZGR 2.0 genes in this pathway
BIOCARTA FCER1 PATHWAY	41	30	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1 PATHWAY	21	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL2 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL3 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA IL6 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY	38	26	All SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY	23	17	All SZGR 2.0 genes in this pathway
BIOCARTA INSULIN PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA ETS PATHWAY	18	12	All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY	18	13	All SZGR 2.0 genes in this pathway
BIOCARTA ARENRF2 PATHWAY	13	9	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY	20	16	All SZGR 2.0 genes in this pathway
BIOCARTA DREAM PATHWAY	14	13	All SZGR 2.0 genes in this pathway
BIOCARTA CARDIACEGF PATHWAY	18	16	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY	24	17	All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES	24	20	All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY	27	23	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY	62	43	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY	45	33	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY	63	54	All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY	47	39	All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY	31	29	All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY	46	39	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY	14	14	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY	59	43	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY	44	35	All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY	47	40	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID PDGFRA PATHWAY	22	18	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID TCR CALCIUM PATHWAY	29	23	All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY	66	52	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY	34	31	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
PID FGF PATHWAY	55	37	All SZGR 2.0 genes in this pathway
PID HNF3A PATHWAY	44	29	All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY	33	29	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	10	8	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN	52	34	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN	198	110	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL DN	69	43	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 DN	45	26	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN	384	220	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP	177	110	All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA DN	62	41	All SZGR 2.0 genes in this pathway
CASORELLI APL SECONDARY VS DE NOVO UP	39	25	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN	384	230	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
BILBAN B CLL LPL DN	42	25	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL DN	118	79	All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP	176	123	All SZGR 2.0 genes in this pathway
NAGASHIMA EGF SIGNALING UP	58	40	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP	171	112	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG UP	130	85	All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A TARGETS DN	91	58	All SZGR 2.0 genes in this pathway
ELVIDGE HIF1A AND HIF2A TARGETS DN	104	72	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP	149	84	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 DN	51	35	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN	142	95	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS E UP	97	60	All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP	271	175	All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS UP	21	16	All SZGR 2.0 genes in this pathway
CHASSOT SKIN WOUND	10	9	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 12HR	43	35	All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 AND DCC TARGETS	35	25	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK1 AND MAPK2 TARGETS	12	10	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK7 TARGETS	8	8	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK11 TARGETS	5	5	All SZGR 2.0 genes in this pathway
TURJANSKI MAPK14 TARGETS	10	10	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 1	45	27	All SZGR 2.0 genes in this pathway
KOBAYASHI RESPONSE TO ROMIDEPSIN	19	14	All SZGR 2.0 genes in this pathway
DACOSTA ERCC3 ALLELE XPCS VS TTD UP	28	19	All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE	105	68	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN	164	111	All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP	57	41	All SZGR 2.0 genes in this pathway
STANHILL HRAS TRANSFROMATION UP	8	5	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP	47	38	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN	156	106	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN	110	78	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP	142	104	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 20 HELA	11	8	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 40 MCF10A	19	11	All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 40 MCF10A	32	21	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11	63	45	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP	197	110	All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL UP	37	28	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION	40	29	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN	66	47	All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION L1 G1 UP	25	15	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 DN	10	5	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP	157	105	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR DN	25	15	All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION	88	68	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN	44	30	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
ASTIER INTEGRIN SIGNALING	59	44	All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN	77	48	All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS DN	32	25	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP	214	133	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS RESPONSE	35	28	All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA	81	64	All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY UP	45	29	All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN	65	45	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA UP	52	33	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP	105	73	All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A DN	76	57	All SZGR 2.0 genes in this pathway
INGA TP53 TARGETS	17	13	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP	156	101	All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP	67	45	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP	244	151	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP	89	59	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 2HR	51	36	All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP	100	72	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP	84	58	All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK	75	47	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP	45	33	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9	92	59	All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE	261	166	All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN	264	168	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN	373	196	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS	92	68	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7	90	52	All SZGR 2.0 genes in this pathway
WANG LSD1 TARGETS DN	39	30	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION UP	20	14	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP	430	288	All SZGR 2.0 genes in this pathway
MISHRA CARCINOMA ASSOCIATED FIBROBLAST UP	24	14	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN	274	165	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN	546	362	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP	223	132	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
KRISHNAN FURIN TARGETS UP	12	6	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
SPIRA SMOKERS LUNG CANCER UP	38	24	All SZGR 2.0 genes in this pathway
ZAIDI OSTEOBLAST TRANSCRIPTION FACTORS	14	12	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
SCHRAETS MLL TARGETS UP	35	21	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP	60	42	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION DN	99	65	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER HEPATOBLAST	16	12	All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS UP	24	14	All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS UP	23	15	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN	306	191	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2	86	50	All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE CURCUMIN SULINDAC TSA 1	10	7	All SZGR 2.0 genes in this pathway
NIELSEN GIST	98	66	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN UP	56	38	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 2HR UP	39	30	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP	281	183	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
DALESSIO TSA RESPONSE	29	16	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 5	11	8	All SZGR 2.0 genes in this pathway
LIU IL13 PRIMING MODEL	15	11	All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP	63	43	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE	227	151	All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF	222	159	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	524	531	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-139	526	532	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-142-5p	483	489	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-144	525	531	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-181	592	598	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-221/222	203	210	1A,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	203	210	1A,m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-29	365	371	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-338	368	374	1A	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-383	567	573	1A	hsa-miR-383^brain	AGAUCAGAAGGUGAUUGUGGCU
miR-543	593	599	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: FOS