Summary ?
GeneID4690
SymbolNCK1
SynonymsNCK|NCKalpha|nck-1
DescriptionNCK adaptor protein 1
ReferenceMIM:600508|HGNC:HGNC:7664|HPRD:02740|
Gene typeprotein-coding
Map location3q21
Pascal p-value1.628E-4
Sherlock p-value0.832

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.6628 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C19orf530.900.83
USE10.890.80
MRPL270.890.83
MRPL200.880.85
MRPL240.880.85
FIS10.870.77
AURKAIP10.860.77
RNF1810.860.77
GPX40.860.78
NDUFA20.860.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BAT2D1-0.42-0.36
SLC6A6-0.38-0.32
TTN-0.37-0.34
AC008740.1-0.37-0.35
MYH9-0.36-0.28
MACF1-0.36-0.31
BDP1-0.36-0.30
RNF213-0.36-0.32
CDH5-0.35-0.32
MTR-0.35-0.28

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)12110186 
GO:0008093cytoskeletal adaptor activityNAS12110186 
GO:0030159receptor signaling complex scaffold activityNAS12110186 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006417regulation of translationIEA-
GO:0007172signal complex assemblyNAS12110186 
GO:0007015actin filament organizationIEA-
GO:0016477cell migrationIEA-
GO:0042110T cell activationIMP12110186 
GO:0042102positive regulation of T cell proliferationIMP12110186 
GO:0030838positive regulation of actin filament polymerizationIMP12110186 
GO:0030032lamellipodium biogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0012506vesicle membraneIEA-
GO:0005737cytoplasmNAS12110186 
GO:0005783endoplasmic reticulumIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI1ABI-1 | E3B1 | NAP1BP | SSH3BP | SSH3BP1abl-interactor 1-HPRD,BioGRID11418237 
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID11494134 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID12135674 
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD,BioGRID9697839 |11487585 
CAV2CAV | MGC12294caveolin 2-HPRD,BioGRID12091389 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceAffinity Capture-WesternBioGRID10204582 |11494134 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)Reconstituted ComplexBioGRID12110186 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Reconstituted ComplexBioGRID8879209 
DAG1156DAG | A3a | AGRNR | DAGdystroglycan 1 (dystrophin-associated glycoprotein 1)Affinity Capture-Western
Reconstituted Complex
BioGRID11724572 
DCCCRC18 | CRCR1deleted in colorectal carcinoma-HPRD,BioGRID12149262 
DNM1DNMdynamin 1-HPRD,BioGRID10206341 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2An unspecified isoform of Dyn2 interacts with Nck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Nck from an unspecified species.BIND15696170 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD12087092 
DOK2p56DOK | p56dok-2docking protein 2, 56kDa-HPRD,BioGRID11689432 
DRD3D3DR | ETM1 | FET1 | MGC149204 | MGC149205dopamine receptor D3D3 interacts with Nck.BIND9843378 
DRD4D4DRdopamine receptor D4D4.7 interacts with Nck.BIND9843378 
DRD4D4DRdopamine receptor D4D4.2 interacts with Nck.BIND9843378 
DRD4D4DRdopamine receptor D4-HPRD,BioGRID9843378 
DRD4D4DRdopamine receptor D4D4.4 interacts with Nck.BIND9843378 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID9362449 
EIF2B2EIF-2Bbeta | EIF2Beukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa-HPRD,BioGRID11959995 
EIF2S2DKFZp686L18198 | EIF2 | EIF2B | EIF2beta | MGC8508eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa-HPRD11959995 
EPHB1ELK | EPHT2 | FLJ37986 | Hek6 | NETEPH receptor B1-HPRD,BioGRID9430661 
EPHB2CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5EPH receptor B2-HPRD9233798 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)Affinity Capture-MSBioGRID16729043 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD,BioGRID11741599 
FLT1FLT | VEGFR1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)Flt-1 interacts with Nck.BIND9600074 
GAB2KIAA0571GRB2-associated binding protein 2Reconstituted ComplexBioGRID10391903 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1-HPRD,BioGRID9010224 |9362449 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)Nck interacts with SLP-76.BIND15558067 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD,BioGRID10229072 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1Reconstituted Complex
Two-hybrid
BioGRID9346925 |9891069 
MAP4K4FLH21957 | FLJ10410 | FLJ20373 | FLJ90111 | HGK | KIAA0687 | NIKmitogen-activated protein kinase kinase kinase kinase 4-HPRD,BioGRID9135144 
MINK1B55 | MAP4K6 | MGC21111 | MINK | YSK2 | ZC3 | hMINK | hMINKbetamisshapen-like kinase 1 (zebrafish)An unspecified isoform of hMINK-beta interacts with Nck. This interaction was modeled on a demonstrated interaction between human hMINK-beta and Nck from an unspecified species.BIND15469942 
MINK1B55 | MAP4K6 | MGC21111 | MINK | YSK2 | ZC3 | hMINK | hMINKbetamisshapen-like kinase 1 (zebrafish)-HPRD,BioGRID15469942 
NCKAP1FLJ11291 | HEM2 | KIAA0587 | MGC8981 | NAP1 | NAP125NCK-associated protein 1-HPRD11418237 
NCKIPSDAF3P21 | DIP | DIP1 | MGC23891 | ORF1 | SPIN90 | WASLBP | WISHNCK interacting protein with SH3 domain-HPRD,BioGRID11278500 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD,BioGRID8879209 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD10808124 
NTRK2GP145-TrkB | TRKBneurotrophic tyrosine kinase, receptor, type 2-HPRD12074588 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD8824201 |11278241 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1Nck interacts with PAK1BIND8824201 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID8824201 
PAK2PAK65 | PAKgammap21 protein (Cdc42/Rac)-activated kinase 2-HPRD11160719 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptideAutophosphorylated PDGFR interacts with Nck. This interaction was modelled on a demonstrated interaction between human PDGFR and Nck from an unspecified species.BIND8890167 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptide-HPRD9362449 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptideAffinity Capture-WesternBioGRID1333047 |10026169 
PFN1-profilin 1Reconstituted ComplexBioGRID9694849 
PKN2MGC150606 | MGC71074 | PAK2 | PRK2 | PRKCL2 | PRO2042 | Pak-2protein kinase N2-HPRD,BioGRID8910519 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-Western
Reconstituted Complex
BioGRID8879209 |11950595 
PXNFLJ16691paxillin-HPRD,BioGRID10330411 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD10766742 
RALGPS1KIAA0351 | RALGEF2 | RALGPS1ARal GEF with PH domain and SH3 binding motif 1Affinity Capture-WesternBioGRID10747847 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD10508618 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1Affinity Capture-WesternBioGRID9233798 
RHOUARHU | CDC42L1 | DJ646B12.2 | FLJ10616 | WRCH1 | fJ646B12.2 | hG28Kras homolog gene family, member UWrch-1 interacts with Nck. This interaction was modeled on a demonstrated interaction between human Wrch-1, and Nck from an unspecified species.BIND15556869 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating proteinNck interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Nck from an unspecified species and human GC-GAP.BIND12819203 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12819203 
RRAS-related RAS viral (r-ras) oncogene homolog-HPRD,BioGRID10671570 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1Socs1 interacts with Nck. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Nck from an unspecified species.BIND10022833 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1-HPRD,BioGRID10022833 
SOCS7NAP4suppressor of cytokine signaling 7-HPRD,BioGRID9344857 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)NCK interacts with SOS. This interaction was modeled on a demonstrated interaction between human NCK and mouse SOS or hamster SOS.BIND7862111 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD7862111 |10026169 
|10206341 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)Affinity Capture-Western
Reconstituted Complex
BioGRID7862111 |8810325 
|10026169 |10206341 
SYNJ2INPP5H | KIAA0348 | MGC44422synaptojanin 2-HPRD10805734 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1-HPRD,BioGRID7706279 
TNIK-TRAF2 and NCK interacting kinase-HPRD10521462 
TNK2ACK | ACK1 | FLJ44758 | FLJ45547 | p21cdc42Hstyrosine kinase, non-receptor, 2-HPRD11278436 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)Affinity Capture-Western
in vitro
in vivo
BioGRID7565724 |10747096 
|12135674 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD7565724 |11340081 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)Nck interacts with WASp.BIND15558067 
WASLDKFZp779G0847 | MGC48327 | N-WASP | NWASPWiskott-Aldrich syndrome-like-HPRD,BioGRID11340081 
WIPF1MGC111041 | PRPL-2 | WASPIP | WIPWAS/WASL interacting protein family, member 1-HPRD,BioGRID9694849 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ERBB SIGNALING PATHWAY 8771All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 5936All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY 2014All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 4533All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY 4532All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
PID RET PATHWAY 3929All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY 3527All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 3227All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 3529All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3124All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY 2623All SZGR 2.0 genes in this pathway
PID ECADHERIN STABILIZATION PATHWAY 4234All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 6957All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 2924All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 2725All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 12293All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION 9576All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC 1411All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR 3026All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING 4130All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 1311All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS 2015All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR DN 8853All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170114All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330217All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
MEINHOLD OVARIAN CANCER LOW GRADE DN 2016All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 BULK DN 2315All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168103All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 11772All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 5035All SZGR 2.0 genes in this pathway
CROMER METASTASIS DN 8158All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C4 1812All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D6 3725All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160101All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217138All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240153All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER WITH BRCA1 MUTATED UP 5627All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP 8363All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1374604661Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG