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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: NCK1

Summary

GeneID

4690

Symbol

NCK1

Synonyms

MGC12668|NCK|NCKalpha

Description

NCK adaptor protein 1

Locus tag

Gene type

protein-coding

Map location

3q21

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.6628

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

C19orf53

0.90

0.83

USE1

0.89

0.80

MRPL27

0.89

0.83

MRPL20

0.88

0.85

MRPL24

0.88

0.85

FIS1

0.87

0.77

AURKAIP1

0.86

0.77

RNF181

0.86

0.77

GPX4

0.86

0.78

NDUFA2

0.86

0.81

Top 10 negatively co-expressed genes

BAT2D1

-0.42

-0.36

SLC6A6

-0.38

-0.32

TTN

-0.37

-0.34

AC008740.1

-0.37

-0.35

MYH9

-0.36

-0.28

MACF1

-0.36

-0.31

BDP1

-0.36

-0.30

RNF213

-0.36

-0.32

CDH5

-0.35

-0.32

MTR

-0.35

-0.28

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005102

receptor binding

IPI

Neurotransmitter (GO term level: 4)

12110186

GO:0008093

cytoskeletal adaptor activity

NAS

12110186

GO:0030159

receptor signaling complex scaffold activity

NAS

12110186

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006417

regulation of translation

IEA

GO:0007172

signal complex assembly

NAS

12110186

GO:0007015

actin filament organization

IEA

GO:0016477

cell migration

IEA

GO:0042110

T cell activation

IMP

12110186

GO:0042102

positive regulation of T cell proliferation

IMP

12110186

GO:0030838

positive regulation of actin filament polymerization

IMP

12110186

GO:0030032

lamellipodium biogenesis

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0012506

vesicle membrane

IEA

GO:0005737

cytoplasm

NAS

12110186

GO:0005783

endoplasmic reticulum

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABI1	ABI-1 \| E3B1 \| NAP1BP \| SSH3BP \| SSH3BP1	abl-interactor 1	-	HPRD,BioGRID	11418237
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD,BioGRID	11494134
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD,BioGRID	12135674
BLNK	BASH \| BLNK-S \| LY57 \| MGC111051 \| SLP-65 \| SLP65	B-cell linker	-	HPRD,BioGRID	9697839 \|11487585
CAV2	CAV \| MGC12294	caveolin 2	-	HPRD,BioGRID	12091389
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Affinity Capture-Western	BioGRID	10204582 \|11494134
CD3E	FLJ18683 \| T3E \| TCRE	CD3e molecule, epsilon (CD3-TCR complex)	Reconstituted Complex	BioGRID	12110186
CRK	CRKII	v-crk sarcoma virus CT10 oncogene homolog (avian)	Reconstituted Complex	BioGRID	8879209
DAG1	156DAG \| A3a \| AGRNR \| DAG	dystroglycan 1 (dystrophin-associated glycoprotein 1)	Affinity Capture-Western Reconstituted Complex	BioGRID	11724572
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	-	HPRD,BioGRID	12149262
DNM1	DNM	dynamin 1	-	HPRD,BioGRID	10206341
DNM2	CMTDI1 \| CMTDIB \| DI-CMTB \| DYN2 \| DYNII	dynamin 2	An unspecified isoform of Dyn2 interacts with Nck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Nck from an unspecified species.	BIND	15696170
DOK1	MGC117395 \| MGC138860 \| P62DOK	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	-	HPRD	12087092
DOK2	p56DOK \| p56dok-2	docking protein 2, 56kDa	-	HPRD,BioGRID	11689432
DRD3	D3DR \| ETM1 \| FET1 \| MGC149204 \| MGC149205	dopamine receptor D3	D3 interacts with Nck.	BIND	9843378
DRD4	D4DR	dopamine receptor D4	D4.7 interacts with Nck.	BIND	9843378
			D4.2 interacts with Nck.	BIND	9843378
			-	HPRD,BioGRID	9843378
			D4.4 interacts with Nck.	BIND	9843378
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD,BioGRID	9362449
EIF2B2	EIF-2Bbeta \| EIF2B	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	-	HPRD,BioGRID	11959995
EIF2S2	DKFZp686L18198 \| EIF2 \| EIF2B \| EIF2beta \| MGC8508	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	-	HPRD	11959995
EPHB1	ELK \| EPHT2 \| FLJ37986 \| Hek6 \| NET	EPH receptor B1	-	HPRD,BioGRID	9430661
EPHB2	CAPB \| DRT \| EPHT3 \| ERK \| Hek5 \| MGC87492 \| PCBC \| Tyro5	EPH receptor B2	-	HPRD	9233798
ERBB4	HER4 \| MGC138404 \| p180erbB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	Affinity Capture-MS	BioGRID	16729043
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	-	HPRD,BioGRID	11741599
FLT1	FLT \| VEGFR1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	Flt-1 interacts with Nck.	BIND	9600074
GAB2	KIAA0571	GRB2-associated binding protein 2	Reconstituted Complex	BioGRID	10391903
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH domain containing, RNA binding, signal transduction associated 1	-	HPRD,BioGRID	9010224 \|9362449
LCP2	SLP-76 \| SLP76	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	Nck interacts with SLP-76.	BIND	15558067
LCP2	SLP-76 \| SLP76		-	HPRD,BioGRID	10229072
MAP4K1	HPK1	mitogen-activated protein kinase kinase kinase kinase 1	Reconstituted Complex Two-hybrid	BioGRID	9346925 \|9891069
MAP4K4	FLH21957 \| FLJ10410 \| FLJ20373 \| FLJ90111 \| HGK \| KIAA0687 \| NIK	mitogen-activated protein kinase kinase kinase kinase 4	-	HPRD,BioGRID	9135144
MINK1	B55 \| MAP4K6 \| MGC21111 \| MINK \| YSK2 \| ZC3 \| hMINK \| hMINKbeta	misshapen-like kinase 1 (zebrafish)	An unspecified isoform of hMINK-beta interacts with Nck. This interaction was modeled on a demonstrated interaction between human hMINK-beta and Nck from an unspecified species.	BIND	15469942
MINK1		misshapen-like kinase 1 (zebrafish)	-	HPRD,BioGRID	15469942
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	-	HPRD	11418237
NCKIPSD	AF3P21 \| DIP \| DIP1 \| MGC23891 \| ORF1 \| SPIN90 \| WASLBP \| WISH	NCK interacting protein with SH3 domain	-	HPRD,BioGRID	11278500
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD,BioGRID	8879209
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1		-	HPRD	10808124
NTRK2	GP145-TrkB \| TRKB	neurotrophic tyrosine kinase, receptor, type 2	-	HPRD	12074588
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD	8824201 \|11278241
			Nck interacts with PAK1	BIND	8824201
			-	HPRD,BioGRID	8824201
PAK2	PAK65 \| PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2	-	HPRD	11160719
PDGFRB	CD140B \| JTK12 \| PDGF-R-beta \| PDGFR \| PDGFR1	platelet-derived growth factor receptor, beta polypeptide	Autophosphorylated PDGFR interacts with Nck. This interaction was modelled on a demonstrated interaction between human PDGFR and Nck from an unspecified species.	BIND	8890167
			-	HPRD	9362449
			Affinity Capture-Western	BioGRID	1333047 \|10026169
PFN1	-	profilin 1	Reconstituted Complex	BioGRID	9694849
PKN2	MGC150606 \| MGC71074 \| PAK2 \| PRK2 \| PRKCL2 \| PRO2042 \| Pak-2	protein kinase N2	-	HPRD,BioGRID	8910519
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	Affinity Capture-Western Reconstituted Complex	BioGRID	8879209 \|11950595
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	10330411
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD	10766742
RALGPS1	KIAA0351 \| RALGEF2 \| RALGPS1A	Ral GEF with PH domain and SH3 binding motif 1	Affinity Capture-Western	BioGRID	10747847
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD	10508618
RASA1		RAS p21 protein activator (GTPase activating protein) 1	Affinity Capture-Western	BioGRID	9233798
RHOU	ARHU \| CDC42L1 \| DJ646B12.2 \| FLJ10616 \| WRCH1 \| fJ646B12.2 \| hG28K	ras homolog gene family, member U	Wrch-1 interacts with Nck. This interaction was modeled on a demonstrated interaction between human Wrch-1, and Nck from an unspecified species.	BIND	15556869
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Nck interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Nck from an unspecified species and human GC-GAP.	BIND	12819203
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	-	HPRD,BioGRID	12819203
RRAS	-	related RAS viral (r-ras) oncogene homolog	-	HPRD,BioGRID	10671570
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	Socs1 interacts with Nck. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Nck from an unspecified species.	BIND	10022833
SOCS1	CIS1 \| CISH1 \| JAB \| SOCS-1 \| SSI-1 \| SSI1 \| TIP3	suppressor of cytokine signaling 1	-	HPRD,BioGRID	10022833
SOCS7	NAP4	suppressor of cytokine signaling 7	-	HPRD,BioGRID	9344857
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	NCK interacts with SOS. This interaction was modeled on a demonstrated interaction between human NCK and mouse SOS or hamster SOS.	BIND	7862111
			-	HPRD	7862111 \|10026169 \|10206341
			Affinity Capture-Western Reconstituted Complex	BioGRID	7862111 \|8810325 \|10026169 \|10206341
SYNJ2	INPP5H \| KIAA0348 \| MGC44422	synaptojanin 2	-	HPRD	10805734
TBK1	FLJ11330 \| NAK \| T2K	TANK-binding kinase 1	-	HPRD,BioGRID	7706279
TNIK	-	TRAF2 and NCK interacting kinase	-	HPRD	10521462
TNK2	ACK \| ACK1 \| FLJ44758 \| FLJ45547 \| p21cdc42Hs	tyrosine kinase, non-receptor, 2	-	HPRD	11278436
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	Affinity Capture-Western in vitro in vivo	BioGRID	7565724 \|10747096 \|12135674
			-	HPRD	7565724 \|11340081
			Nck interacts with WASp.	BIND	15558067
WASL	DKFZp779G0847 \| MGC48327 \| N-WASP \| NWASP	Wiskott-Aldrich syndrome-like	-	HPRD,BioGRID	11340081
WIPF1	MGC111041 \| PRPL-2 \| WASPIP \| WIP	WAS/WASL interacting protein family, member 1	-	HPRD,BioGRID	9694849

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_ERBB_SIGNALING_PATHWAY	87	71	All SZGR genes in this pathway
KEGG_AXON_GUIDANCE	129	103	All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	108	89	All SZGR genes in this pathway
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION	59	36	All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY	20	14	All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION	45	33	All SZGR genes in this pathway
PID_INSULIN_PATHWAY	45	32	All SZGR genes in this pathway
PID_TCR_PATHWAY	66	51	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY	40	38	All SZGR genes in this pathway
PID_RET_PATHWAY	39	29	All SZGR genes in this pathway
PID_ARF6_PATHWAY	35	27	All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	50	41	All SZGR genes in this pathway
PID_NETRIN_PATHWAY	32	27	All SZGR genes in this pathway
PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY	35	29	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY	31	24	All SZGR genes in this pathway
PID_VEGFR1_PATHWAY	26	23	All SZGR genes in this pathway
PID_ECADHERIN_STABILIZATION_PATHWAY	42	34	All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY	69	57	All SZGR genes in this pathway
PID_FAK_PATHWAY	59	45	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION	120	77	All SZGR genes in this pathway
REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	29	24	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR	126	90	All SZGR genes in this pathway
REACTOME_TCR_SIGNALING	54	46	All SZGR genes in this pathway
REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES	27	25	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF	122	93	All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION	95	76	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_RAC	14	11	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR	30	26	All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING	41	30	All SZGR genes in this pathway
REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	13	11	All SZGR genes in this pathway
REACTOME_NEPHRIN_INTERACTIONS	20	15	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN	634	384	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN	455	304	All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP	305	185	All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_DN	88	53	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP	552	347	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP	211	136	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP	170	114	All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL	330	217	All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL	330	215	All SZGR genes in this pathway
MEINHOLD_OVARIAN_CANCER_LOW_GRADE_DN	20	16	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	855	609	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	483	336	All SZGR genes in this pathway
YANG_BREAST_CANCER_ESR1_BULK_DN	23	15	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN	584	395	All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK	168	103	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK	423	265	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK	779	480	All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK	117	72	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP	1037	673	All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP	223	140	All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP	50	35	All SZGR genes in this pathway
CROMER_METASTASIS_DN	81	58	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN	504	323	All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C4	18	12	All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D6	37	25	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN	312	203	All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN	318	220	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN	160	101	All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS	217	138	All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN	154	101	All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN	240	153	All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12	317	177	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway
PUJANA_BREAST_CANCER_WITH_BRCA1_MUTATED_UP	56	27	All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP	83	63	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN	918	550	All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B	517	302	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	460	466	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.