Gene Page: SDC2

Summary
GeneID  6383
Symbol  SDC2
Synonyms  HSPG|HSPG1|SYND2
Description  syndecan 2
See related  HGNC:10659|MIM:142460|Ensembl:ENSG00000169439|HPRD:00803|
Locus tag  -
Gene type  protein-coding
Map location  8q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0329 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF4160.920.88
PRPSAP20.920.89
WDR700.920.90
BZW20.910.92
ZNF5550.910.85
RFWD20.910.90
YTHDF20.910.84
C12orf410.910.90
EIF4A10.900.90
ZNF2590.900.87
Top 10 negatively co-expressed genes
AF347015.33-0.73-0.87
AF347015.27-0.72-0.84
MT-CO2-0.72-0.83
MT-CYB-0.72-0.86
AF347015.31-0.72-0.83
AIFM3-0.71-0.79
AF347015.8-0.70-0.85
HLA-F-0.70-0.76
HEPN1-0.70-0.77
AF347015.15-0.70-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0008092cytoskeletal protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008150biological_processND-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneNAS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APOEAD2 | LPG | MGC1571 | apoproteinapolipoprotein E-HPRD9869645 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)-HPRD,BioGRID9660868 
CSF2GMCSF | MGC131935 | MGC138897colony stimulating factor 2 (granulocyte-macrophage)-HPRD,BioGRID10734053 
CSF2RACD116 | CDw116 | CSF2R | CSF2RAX | CSF2RAY | CSF2RX | CSF2RY | GM-CSF-R-alpha | GMCSFR | GMR | MGC3848 | MGC4838colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)Affinity Capture-WesternBioGRID10734053 
EPB41L14.1N | DKFZp686H17242 | KIAA0338 | MGC11072erythrocyte membrane protein band 4.1-like 1Affinity Capture-WesternBioGRID12676536 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrin-HPRD,BioGRID10704377 
FGF2BFGF | FGFB | HBGF-2fibroblast growth factor 2 (basic)Co-purificationBioGRID16982797 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD,BioGRID10772816 
HGFF-TCF | HGFB | HPTA | SFhepatocyte growth factor (hepapoietin A; scatter factor)-HPRD,BioGRID8157651 
ITPR1INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16inositol 1,4,5-triphosphate receptor, type 1Affinity Capture-WesternBioGRID12676536 
KAL1ADMLX | HHA | KAL | KALIG-1 | KMSKallmann syndrome 1 sequence-HPRD,BioGRID8832397 
LAMA3BM600 | E170 | LAMNA | LOCS | lama3alaminin, alpha 3-HPRD,BioGRID11373281 
PF4CXCL4 | MGC138298 | SCYB4platelet factor 4-HPRD,BioGRID7524669 
REG3AHIP | INGAP | PAP | PAP-H | PAP1 | PBCGF | REG-III | REG3regenerating islet-derived 3 alpha-HPRD,BioGRID8997243 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)-HPRD,BioGRID9391086 
SERPINC1AT3 | ATIII | MGC22579serpin peptidase inhibitor, clade C (antithrombin), member 1-HPRD1315572 
SPARCONsecreted protein, acidic, cysteine-rich (osteonectin)-HPRD2745554 
TRAPPC4CGI-104 | HSPC172 | PTD009 | SBDN | SYNBINDIN | TRS23trafficking protein particle complex 4-HPRD11018053 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ECM_RECEPTOR_INTERACTION 8453All SZGR genes in this pathway
KEGG_CELL_ADHESION_MOLECULES_CAMS 13493All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
REACTOME_HS_GAG_DEGRADATION 2015All SZGR genes in this pathway
REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM 4933All SZGR genes in this pathway
REACTOME_HS_GAG_BIOSYNTHESIS 3117All SZGR genes in this pathway
REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM 5233All SZGR genes in this pathway
REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 11169All SZGR genes in this pathway
REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS 2517All SZGR genes in this pathway
REACTOME_METABOLISM_OF_CARBOHYDRATES 247154All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN 5438All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_DN 232139All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_DN 13377All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
HERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_1_DN 3823All SZGR genes in this pathway
SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION 5031All SZGR genes in this pathway
HASINA_NOL7_TARGETS_DN 139All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BALDWIN_PRKCI_TARGETS_UP 3526All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
WANG_PROSTATE_CANCER_ANDROGEN_INDEPENDENT 6637All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON 13282All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 7151All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_UP 3728All SZGR genes in this pathway
SMITH_LIVER_CANCER 4527All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD2_UP 4532All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_DN 5742All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN 3623All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN 159105All SZGR genes in this pathway
GU_PDEF_TARGETS_UP 7149All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
NABA_ECM_AFFILIATED 17189All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1192819341Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-182219221981Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-1861571631Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429757763m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-218988994m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367465471m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-272012071Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-376c9179241A,m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-485-5p7317371Ahsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-493-5p11311137m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-49910191025m8hsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-5004644701Ahsa-miR-500AUGCACCUGGGCAAGGAUUCUG
miR-9142814341Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96219121981A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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