SZGR2

Summary ?

GeneID	6929
Symbol	TCF3
Synonyms	E2A\|E47\|ITF1\|TCF-3\|VDIR\|bHLHb21
Description	transcription factor 3
Reference	MIM:147141\|HGNC:HGNC:11633\|Ensembl:ENSG00000071564\|HPRD:00918\|Vega:OTTHUMG00000180031
Gene type	protein-coding
Map location	19p13.3
Pascal p-value	0.012
Fetal beta	0.472
DMG	2 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Montano_2016	Genome-wide DNA methylation analysis	This dataset includes 172 replicated associations between CpGs with schizophrenia.	2
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	2

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg23009327	19	1630248	TCF3	1.32E-6	0.01	0.017	DMG:Montano_2016
cg21030400	19	2052564	TCF3	2.31E-4	-3.744		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ASCL3	HASH3 \| SGN1 \| bHLHa42	achaete-scute complex homolog 3 (Drosophila)	-	HPRD	11784080
BHLHB8	MIST1 \| bHLHa15	basic helix-loop-helix domain containing, class B, 8	-	HPRD	9073453
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD,BioGRID	10757985
CALM3	PHKD \| PHKD3	calmodulin 3 (phosphorylase kinase, delta)	-	HPRD	10757985
CBFA2T3	ETO2 \| MTG16 \| MTGR2 \| ZMYND4	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	Affinity Capture-Western Reconstituted Complex	BioGRID	16407974
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	12435739
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	12107263
ELK3	ERP \| NET \| SAP2	ELK3, ETS-domain protein (SRF accessory protein 2)	-	HPRD,BioGRID	8918463
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	12435739
FERD3L	MGC119861 \| N-TWIST \| NATO3 \| NTWIST	Fer3-like (Drosophila)	-	HPRD	12217327
GARNL1	DKFZp566D133 \| DKFZp667F074 \| GRIPE \| KIAA0884 \| TULIP1	GTPase activating Rap/RanGAP domain-like 1	-	HPRD,BioGRID	12200424
HAND1	Hxt \| Thing1 \| bHLHa27 \| eHand	heart and neural crest derivatives expressed 1	-	HPRD	10924525 \|11802795
HAND2	DHAND2 \| FLJ16260 \| Hed \| MGC125303 \| MGC125304 \| Thing2 \| bHLHa26 \| dHand	heart and neural crest derivatives expressed 2	-	HPRD,BioGRID	11812799
ID1	ID \| bHLHb24	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	Two-hybrid	BioGRID	9242638
ID2	GIG8 \| ID2A \| ID2H \| MGC26389 \| bHLHb26	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	-	HPRD,BioGRID	9242638
ID3	HEIR-1 \| bHLHb25	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	-	HPRD	8759016 \|9525934
ID3	HEIR-1 \| bHLHb25	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	Reconstituted Complex Two-hybrid	BioGRID	9242638 \|9525934
KAT2B	CAF \| P \| P/CAF \| PCAF	K(lysine) acetyltransferase 2B	-	HPRD,BioGRID	12435739
LDB1	CLIM2 \| NLI	LIM domain binding 1	Affinity Capture-Western	BioGRID	16407974
LMX1A	LMX-1 \| LMX1 \| LMX1.1 \| MGC87616	LIM homeobox transcription factor 1, alpha	Reconstituted Complex Two-hybrid	BioGRID	9199284
LYL1	bHLHa18	lymphoblastic leukemia derived sequence 1	-	HPRD,BioGRID	8628307
MAPKAPK2	MK2	mitogen-activated protein kinase-activated protein kinase 2	-	HPRD,BioGRID	10781029
MAPKAPK3	3PK \| MAPKAP3	mitogen-activated protein kinase-activated protein kinase 3	-	HPRD,BioGRID	10781029
MSC	ABF-1 \| ABF1 \| MYOR \| bHLHa22	musculin (activated B-cell factor-1)	-	HPRD	9584154
MYF5	bHLHc2	myogenic factor 5	Two-hybrid	BioGRID	9242638
MYF6	MRF4 \| bHLHc4	myogenic factor 6 (herculin)	Two-hybrid	BioGRID	9242638
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD	1649701 \|9001211 \|9184158
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	in vitro in vivo Reconstituted Complex Two-hybrid	BioGRID	1649701 \|9184158 \|9242638
MYOG	MYF4 \| MYOGENIN \| bHLHc3	myogenin (myogenic factor 4)	in vitro in vivo Two-hybrid	BioGRID	1325437 \|2163343 \|9242638
MYOG	MYF4 \| MYOGENIN \| bHLHc3	myogenin (myogenic factor 4)	-	HPRD	1649701
NEDD9	CAS-L \| CAS2 \| CASL \| CASS2 \| HEF1 \| dJ49G10.2 \| dJ761I2.1	neural precursor cell expressed, developmentally down-regulated 9	-	HPRD	10502414
NHLH1	HEN1 \| NSCL \| NSCL1 \| bHLHa35	nescient helix loop helix 1	Two-hybrid	BioGRID	12878195
PDX1	GSF \| IDX-1 \| IPF1 \| IUF1 \| MODY4 \| PDX-1 \| STF-1	pancreatic and duodenal homeobox 1	-	HPRD,BioGRID	10636926
PSMD4	AF \| AF-1 \| ASF \| MCB1 \| Rpn10 \| S5A \| pUB-R5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	-	HPRD,BioGRID	9235903
PSMD9	MGC8644 \| Rpn4 \| p27	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	-	HPRD	10567574
PTF1A	PTF1-p48 \| bHLHa29	pancreas specific transcription factor, 1a	-	HPRD,BioGRID	1720355 \|10768861
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	ETO interacts with E2A.	BIND	15333839
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	-	HPRD,BioGRID	14592976
TAL1	SCL \| TCL5 \| bHLHa17 \| tal-1	T-cell acute lymphocytic leukemia 1	-	HPRD	8159721\|9507011
TAL1	SCL \| TCL5 \| bHLHa17 \| tal-1	T-cell acute lymphocytic leukemia 1	Affinity Capture-MS Affinity Capture-Western in vitro in vivo Reconstituted Complex Two-hybrid	BioGRID	8159721 \|16407974
TAL2	bHLHa19	T-cell acute lymphocytic leukemia 2	-	HPRD	8152805
TCF12	HEB \| HTF4 \| HsT17266 \| bHLHb20	transcription factor 12	-	HPRD,BioGRID	1446075 \|12566462
TCF3	E2A \| ITF1 \| MGC129647 \| MGC129648 \| bHLHb21	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	Co-fractionation	BioGRID	12435739
TCF3	E2A \| ITF1 \| MGC129647 \| MGC129648 \| bHLHb21	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	-	HPRD	2503252 \|7623842
TCF4	E2-2 \| ITF2 \| MGC149723 \| MGC149724 \| PTHS \| SEF2 \| SEF2-1 \| SEF2-1A \| SEF2-1B \| bHLHb19	transcription factor 4	-	HPRD	8999959
TFPT	FB1 \| INO80F \| amida	TCF3 (E2A) fusion partner (in childhood Leukemia)	-	HPRD	10086727
TWIST1	ACS3 \| BPES2 \| BPES3 \| SCS \| TWIST \| bHLHa38	twist homolog 1 (Drosophila)	-	HPRD,BioGRID	10749989
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Reconstituted Complex Two-hybrid	BioGRID	10497239

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS	28	20	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN	281	186	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN	536	332	All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA UP	43	27	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP	194	112	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION	45	34	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5	94	59	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP	110	69	All SZGR 2.0 genes in this pathway
GOLUB ALL VS AML UP	24	20	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN	68	44	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA DN	19	14	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN	246	180	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN	54	30	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH	60	42	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK	75	47	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6	17	9	All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2	71	42	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3	97	72	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN	154	101	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP	295	149	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING	246	152	All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN	45	31	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER DN	56	36	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C	69	49	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
MUELLER COMMON TARGETS OF AML FUSIONS UP	14	10	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN	181	97	All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN	41	25	All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN	42	23	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP	72	53	All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 DN	46	31	All SZGR 2.0 genes in this pathway
THILLAINADESAN ZNF217 TARGETS UP	44	22	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN	448	282	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway

Gene Page: TCF3