SZGR2

Summary ?

GeneID	7341
Symbol	SUMO1
Synonyms	DAP1\|GMP1\|OFC10\|PIC1\|SENP2\|SMT3\|SMT3C\|SMT3H3\|UBL1
Description	small ubiquitin-like modifier 1
Reference	MIM:601912\|HGNC:HGNC:12502\|Ensembl:ENSG00000116030\|HPRD:03554\|Vega:OTTHUMG00000132839
Gene type	protein-coding
Map location	2q33
Pascal p-value	0.257
Sherlock p-value	0.665
Fetal beta	0.48
DMG	1 (# studies)
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg02592124	2	203103479	SUMO1	2.47E-10	-0.011	6.18E-7	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs823066	chr1	205771172	SUMO1	7341	0.12	trans
rs9882137	chr3	29494146	SUMO1	7341	0.07	trans
rs4491879	chr3	189373908	SUMO1	7341	0.11	trans
rs4505678	chr3	189374356	SUMO1	7341	0.08	trans
rs13175086	chr5	174691428	SUMO1	7341	0.15	trans
rs16894557	chr6	28999825	SUMO1	7341	0.1	trans
rs1999514	chr13	84147878	SUMO1	7341	0.16	trans
rs917836	chr18	20053367	SUMO1	7341	0.16	trans
rs1503026	chr18	70842605	SUMO1	7341	0.01	trans
rs12326929	chr18	70864592	SUMO1	7341	0.01	trans
rs12327665	chr19	39622639	SUMO1	7341	0.05	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SLC25A11	0.91	0.92
C19orf62	0.89	0.87
PSMD8	0.89	0.86
MRPL4	0.88	0.88
WDR45	0.88	0.87
ANKRD39	0.88	0.85
MRPL38	0.88	0.87
APEH	0.88	0.85
TMEM9	0.88	0.86
STOML2	0.87	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.18	-0.59	-0.48
AC010300.1	-0.55	-0.60
MT-ATP8	-0.54	-0.41
AF347015.26	-0.53	-0.39
AF347015.8	-0.53	-0.37
AF347015.2	-0.50	-0.33
AF347015.15	-0.49	-0.35
C10orf108	-0.49	-0.45
AC100783.1	-0.48	-0.41
AF347015.21	-0.48	-0.33

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
C11orf65	MGC33948	chromosome 11 open reading frame 65	Two-hybrid	BioGRID	16189514
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	CASP8 (caspase-8) interacts with SUMO1.	BIND	15782135
CBX4	NBP16 \| PC2 \| hPC2	chromobox homolog 4 (Pc class homolog, Drosophila)	Pc2 interacts with SUMO1.	BIND	15592428
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	Two-hybrid	BioGRID	8906799
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	SUMO-1 interacts with CHD3.	BIND	14609633
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	-	HPRD	14609633
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	Two-hybrid	BioGRID	10961991
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	Daxx interacts with sentrin.	BIND	11112409
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	-	HPRD,BioGRID	11112409
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	Daxx interacts with an unspecified isoform of SUMO1.	BIND	11948183
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	Dnmt3b interacts with SUMO-1.	BIND	11735126
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	-	HPRD,BioGRID	11735126
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	Two-hybrid	BioGRID	8906799
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	Reconstituted Complex Two-hybrid	BioGRID	8906799 \|11112409
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	Fas interacts with sentrin.	BIND	11112409
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	-	HPRD	8906799 \|9740801
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	-	HPRD,BioGRID	8906799
HDAC9	DKFZp779K1053 \| HD7 \| HDAC \| HDAC7 \| HDAC7B \| HDAC9B \| HDAC9FL \| HDRP \| KIAA0744 \| MITR	histone deacetylase 9	-	HPRD	12590135
HIPK2	DKFZp686K02111 \| FLJ23711 \| PRO0593	homeodomain interacting protein kinase 2	SUMO-1 interacts with HIPK2.	BIND	14609633
HIPK2	DKFZp686K02111 \| FLJ23711 \| PRO0593	homeodomain interacting protein kinase 2	-	HPRD,BioGRID	14609633
HIPK3	DYRK6 \| FIST3 \| PKY \| YAK1	homeodomain interacting protein kinase 3	Two-hybrid	BioGRID	10961991
HTT	HD \| IT15	huntingtin	HD is covalently attached to SUMO-1 via lysine residues.	BIND	15064418
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	-	HPRD	10892746
MITF	MI \| WS2A \| bHLHe32	microphthalmia-associated transcription factor	-	HPRD,BioGRID	10694430
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD	12193561
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	protein inhibitor of activated STAT, 1	SUMO-1 interacts with PIAS1.	BIND	14609633
PIAS1	DDXBP1 \| GBP \| GU/RH-II \| MGC141878 \| MGC141879 \| ZMIZ3	protein inhibitor of activated STAT, 1	-	HPRD,BioGRID	11583632
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	protein inhibitor of activated STAT, 2	SUMO-1 interacts with PIASxbeta.	BIND	14609633
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	protein inhibitor of activated STAT, 2	Two-hybrid	BioGRID	14609633
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD	8806687 \|11080164
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	Affinity Capture-Western in vitro in vivo Two-hybrid	BioGRID	8806687 \|9452416 \|11948183
PPM1J	DKFZp434P1514 \| FLJ35951 \| MGC19531 \| MGC90149 \| PP2CZ \| PP2Czeta \| PPP2CZ	protein phosphatase 1J (PP2C domain containing)	-	HPRD	12633878
RAD51	BRCC5 \| HRAD51 \| HsRad51 \| HsT16930 \| RAD51A \| RECA	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	-	HPRD,BioGRID	8812453 \|9891849
RAD52	-	RAD52 homolog (S. cerevisiae)	Two-hybrid	BioGRID	8812453
RANBP2	NUP358 \| TRP1 \| TRP2	RAN binding protein 2	Reconstituted Complex	BioGRID	12192048
RANBP2	NUP358 \| TRP1 \| TRP2	RAN binding protein 2	SUMO-1 interacts with RanBP2.	BIND	15608651
RANGAP1	Fug1 \| KIAA1835 \| MGC20266 \| SD	Ran GTPase activating protein 1	-	HPRD	9019411
RANGAP1	Fug1 \| KIAA1835 \| MGC20266 \| SD	Ran GTPase activating protein 1	RanGAP1 interacts with and is covalently modified by SUMO-1.	BIND	9920803
RANGAP1	Fug1 \| KIAA1835 \| MGC20266 \| SD	Ran GTPase activating protein 1	Reconstituted Complex	BioGRID	12924945
SAE1	AOS1 \| FLJ3091 \| HSPC140 \| SUA1	SUMO1 activating enzyme subunit 1	Reconstituted Complex	BioGRID	12924945
SAE1	AOS1 \| FLJ3091 \| HSPC140 \| SUA1	SUMO1 activating enzyme subunit 1	-	HPRD	10187858
SALL1	HSAL1 \| TBS \| ZNF794	sal-like 1 (Drosophila)	-	HPRD,BioGRID	12200128
SALL1	HSAL1 \| TBS \| ZNF794	sal-like 1 (Drosophila)	SALL1 interacts with SUMO-1.	BIND	12200128
SENP2	AXAM2 \| DKFZp762A2316 \| KIAA1331 \| SMT3IP2	SUMO1/sentrin/SMT3 specific peptidase 2	-	HPRD	11997515
SENP2	AXAM2 \| DKFZp762A2316 \| KIAA1331 \| SMT3IP2	SUMO1/sentrin/SMT3 specific peptidase 2	Biochemical Activity	BioGRID	12192048
SENP6	FLJ11355 \| FLJ11887 \| KIAA0389 \| KIAA0797 \| SSP1 \| SUSP1	SUMO1/sentrin specific peptidase 6	-	HPRD	10799485
SLC2A1	DYT17 \| DYT18 \| GLUT \| GLUT1 \| MGC141895 \| MGC141896 \| PED	solute carrier family 2 (facilitated glucose transporter), member 1	-	HPRD	10655495
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	SMAD4 is sumoylated.	BIND	15592428
SP100	DKFZp686E07254 \| FLJ00340 \| FLJ34579	SP100 nuclear antigen	Two-hybrid	BioGRID	16189514
SREBF2	SREBP2 \| bHLHd2	sterol regulatory element binding transcription factor 2	-	HPRD	12615929
STAB2	DKFZp434E0321 \| FEEL-2 \| FELE-2 \| FELL \| FELL-2 \| FEX2 \| HARE \| STAB-2	stabilin 2	Biochemical Activity	BioGRID	14701874
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	Two-hybrid	BioGRID	10961991 \|11112409
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	Sentrin interacts with sentrin to form a homodimer.	BIND	11112409
TDG	-	thymine-DNA glycosylase	-	HPRD,BioGRID	11889051
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	Reconstituted Complex Two-hybrid	BioGRID	8906799 \|10187798
TOE1	FLJ13949	target of EGR1, member 1 (nuclear)	Two-hybrid	BioGRID	16169070
TOP1	TOPI	topoisomerase (DNA) I	-	HPRD,BioGRID	11709553
TOP2A	TOP2 \| TP2A	topoisomerase (DNA) II alpha 170kDa	-	HPRD,BioGRID	10862613 \|12832072
TOP2B	TOPIIB \| top2beta	topoisomerase (DNA) II beta 180kDa	-	HPRD,BioGRID	10862613
TOPORS	LUN \| P53BP3 \| RP31 \| TP53BPL	topoisomerase I binding, arginine/serine-rich	-	HPRD	11842245
TOPORS	LUN \| P53BP3 \| RP31 \| TP53BPL	topoisomerase I binding, arginine/serine-rich	Two-hybrid	BioGRID	14516784
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	10961991
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p53 interacts with SUMO-1. This interaction was modelled on a demonstrated interaction between p53 from human and SUMO-1 from an unspecified species.	BIND	10788439
TP73	P73	tumor protein p73	Two-hybrid	BioGRID	10961991
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	SUMO-1 interacts with TTRAP.	BIND	14609633
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	Two-hybrid	BioGRID	14609633
UBA2	ARX \| FLJ13058 \| HRIHFB2115 \| SAE2	ubiquitin-like modifier activating enzyme 2	SAE2 and an unspecified isoform of SUMO-1 form thioester bond. This interaction was modeled on a demonstrated interaction between SAE2 from an unspecified species and SUMO-1 from an unspecified species.	BIND	15546615
UBA2	ARX \| FLJ13058 \| HRIHFB2115 \| SAE2	ubiquitin-like modifier activating enzyme 2	-	HPRD,BioGRID	10217437
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-	HPRD,BioGRID	12924945
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	Ubc9 interacts with SUMO1.	BIND	15592428
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	hUbc9 interacts with SUMO-1.	BIND	9920803

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA PML PATHWAY	17	12	All SZGR 2.0 genes in this pathway
BIOCARTA PARKIN PATHWAY	13	8	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNG SIGNALING	14	10	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING	63	48	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE UP	152	90	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
CHOI ATL CHRONIC VS ACUTE DN	18	10	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP	117	85	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP	61	25	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP	344	180	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN	517	309	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN	200	112	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SUBGROUPS	30	20	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER	83	52	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10	69	38	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP	104	67	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Gene Page: SUMO1